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Atomic structure of essential circadian clock protein complex determined

Atomic structure of essential circadian clock protein complex determined

Structural biologists have made important progress towards better understanding the functioning of the circadian clock. The circadian or inner clock coordinates the sleep-wake rhythm and many other body processes that regulate, for example, metabolism, blood pressure, and the immune system Continue reading

Neural transplant reduces absence epilepsy seizures in mice

Neural transplant reduces absence epilepsy seizures in mice

New research from North Carolina State University pinpoints the areas of the cerebral cortex that are affected in mice with absence epilepsy and shows that transplanting embryonic neural cells into these areas can alleviate symptoms of the disease by reducing seizure activity. The work may help identify the areas of the human brain affected in absence epilepsy and lead to new therapies for sufferers. Continue reading

Neural transplant reduces absence epilepsy seizures in mice

Neural transplant reduces absence epilepsy seizures in mice

New research from North Carolina State University pinpoints the areas of the cerebral cortex that are affected in mice with absence epilepsy and shows that transplanting embryonic neural cells into these areas can alleviate symptoms of the disease by reducing seizure activity. The work may help identify the areas of the human brain affected in absence epilepsy and lead to new therapies for sufferers. Absence epilepsy primarily affects children. Continue reading

New approach to HIV vaccine explored by scientists

New approach to HIV vaccine explored by scientists

Using a genetically modified form of the HIV virus, a team of University of Nebraska-Lincoln scientists has developed a promising new approach that could someday lead to a more effective HIV vaccine. The team, led by chemist Jiantao Guo, virologist Qingsheng Li and synthetic biologist Wei Niu, has successfully tested the novel approach for vaccine development in vitro and has published findings in the international edition of the German journal Angewandte Chemie. With the new approach, the UNL team is able to use an attenuated — or weakened — HIV virus in the vaccine Continue reading

Zinc deficiency before conception disrupts fetal development

Zinc deficiency before conception disrupts fetal development

Female mice deprived of dietary zinc for a relatively short time before conception experienced fertility and pregnancy problems and had smaller, less-developed fetuses than mice that ingested zinc during the same times, according to researchers in Penn State’s College of Agricultural Sciences. Continue reading

Toxins in the environment might make you older than your years

Toxins in the environment might make you older than your years

Why are some 75-year-olds downright spry while others can barely get around? Part of the explanation, say researchers writing in the Cell Press journal Trends in Molecular Medicine on May 28, is differences from one person to the next in exposure to harmful substances in the environment, chemicals such as benzene, cigarette smoke, and even stress Continue reading

Major discovery on the mechanism of drug resistance in leukemia and other cancers

Major discovery on the mechanism of drug resistance in leukemia and other cancers

A mechanism that enables the development of resistance to Acute Myeloid Leukemia (AML) anticancer drugs, thereby leading to relapse, has been identified by Kathy Borden of the University of Montreal’s Institute for Research in Immunology and Cancer (IRIC) and her collaborators. Kathy Borden is a Principal Investigator at IRIC and a professor at the university’s Department of Pathology and Cell Biology. Continue reading

Intertwined evolution of human brain and brawn

Intertwined evolution of human brain and brawn

The cognitive differences between humans and our closest living cousins, the chimpanzees, are staggeringly obvious. Although we share strong superficial physical similarities, we have been able to use our incredible mental abilities to construct civilisations and manipulate our environment to our will, allowing us to take over our planet and walk on the moon while the chimps grub around in a few remaining African forests. But a new study suggests that human muscle may be just as unique Continue reading

Intertwined evolution of human brain and brawn

Intertwined evolution of human brain and brawn

The cognitive differences between humans and our closest living cousins, the chimpanzees, are staggeringly obvious. Although we share strong superficial physical similarities, we have been able to use our incredible mental abilities to construct civilisations and manipulate our environment to our will, allowing us to take over our planet and walk on the moon while the chimps grub around in a few remaining African forests. But a new study suggests that human muscle may be just as unique Continue reading

‘Virtual human’ shows that stiff arteries can explain cause of high blood pressure

‘Virtual human’ shows that stiff arteries can explain cause of high blood pressure

High blood pressure is highly age-related and affects more than 1 billion people worldwide. But doctors can’t fully explain the cause of 90 per cent of all cases. Continue reading