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‘Mega’ cells control growth of blood-producing cells

‘Mega’ cells control growth of blood-producing cells

While megakaryocytes are best known for producing platelets that heal wounds, these “mega” cells found in bone marrow also play a critical role in regulating stem cells according to new research from the Stowers Institute for Medical Research. In fact, hematopoietic stem cells differentiate to generate megakaryocytes in bone marrow. The Stowers study is the first to show that hematopoietic stem cells (the parent cells) can be directly controlled by their own progeny (megakaryocytes). Continue reading

New at-risk group identified for gastrointestinal stromal tumors

New at-risk group identified for gastrointestinal stromal tumors

Researchers at the University of California, San Diego School of Medicine have, for the first time, clearly defined the epidemiology of gastrointestinal stromal tumors (GIST), which occur primarily in the lining of the stomach and small intestine. One key finding: Patients of Asian descent, who have not previously been identified as an at-risk population, are 1.5 times more likely than other patient groups to be diagnosed with this type of tumor. Results of the study were published this week in Cancer Epidemiology, Biomarkers & Prevention , a journal of the American Association for Cancer Research. Continue reading

Identifying cyst-laden meat: Sarcocystis thermostable PCR detection kit developed

Identifying cyst-laden meat: Sarcocystis thermostable PCR detection kit developed

Consumption of undercooked cyst-laden meat from cattle, sheep and goats may cause infection in humans. Researchers from Universiti Teknologi MARA have successfully invented a PCR kit which provides a suitable and feasible means of screening, detection and identification with high sensitivity and specificity of the parasite. Continue reading

Overall survival benefit for patients with Stage III soft tissue sarcomas

Overall survival benefit for patients with Stage III soft tissue sarcomas

Fox Chase Cancer Center researchers have carried out the first retrospective analysis of adjuvant chemotherapy’s impact on overall survival in patients with stage III soft tissue sarcomas (STS), adjusted for socioeconomic status and other variables. Continue reading

Mapping atherosclerotic arteries: Combined approach developed

Mapping atherosclerotic arteries: Combined approach developed

A new method allows calcified and constricted blood vessels to be visualized with micrometer precision, and can be used to design containers for targeted drug delivery. Within the project “NO-stress,” materials scientists from the Medical Faculty of the University of Basel combined cutting-edge-imaging techniques to visualize and quantify the constrictions caused by atherosclerosis. Cardiovascular diseases, including atherosclerosis, are associated with plaque formation and the most prevalent cause of death worldwide Continue reading

Mapping atherosclerotic arteries: Combined approach developed

Mapping atherosclerotic arteries: Combined approach developed

A new method allows calcified and constricted blood vessels to be visualized with micrometer precision, and can be used to design containers for targeted drug delivery. Continue reading

New method for analyzing proteins in tissue samples

New method for analyzing proteins in tissue samples

A new way of preparing patient tissue for analyses might soon become the new standard. Continue reading

Characteristics of lung cancers arising in genetic mutation carriers

Characteristics of lung cancers arising in genetic mutation carriers

Two studies are providing new insight into germline epidermal growth factor receptor ( EGFR ) T790M mutation in familial non-small cell lung cancer (NSCLC). The findings suggest the need for tailored approaches for early detection and treatment, as well as for genetic testing to identify carriers. Continue reading

Into the mind of the common fruit fly

Into the mind of the common fruit fly

ScienceDaily (Sep. 25, 2012) — Although they’re a common nuisance in the home, fruit flies have made great contributions to research in genetics and developmental biology. Now a Tel Aviv University researcher is again turning to this everyday pest to answer crucial questions about how neurons function at a cellular level — which may uncover the secrets of neurological disorders such as Alzheimer’s disease Continue reading

Annual screening with chest X-ray does not reduce rate of lung cancer deaths, study finds

Annual screening with chest X-ray does not reduce rate of lung cancer deaths, study finds

ScienceDaily (Oct. 26, 2011) — In a trial that included more than 150,000 participants, those who underwent annual chest radiographic screening for up to 4 years did not have a significantly lower rate of death from lung cancer compared to participants who were not screened, according to a study in the November 2 issue of JAMA Continue reading