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Chemists discover structure of cancer drug candidate

Chemists discover structure of cancer drug candidate

Chemists at The Scripps Research Institute (TSRI) have determined the correct structure of a highly promising anticancer compound approved by the U.S. Continue reading

Study debunks common myth that urine is sterile: Bacterial differences found in urine of healthy women and women with overactive bladder

Study debunks common myth that urine is sterile: Bacterial differences found in urine of healthy women and women with overactive bladder

Bacteria live in the bladders of healthy women, discrediting the common belief that normal urine is sterile. Continue reading

Study debunks common myth that urine is sterile: Bacterial differences found in urine of healthy women and women with overactive bladder

Study debunks common myth that urine is sterile: Bacterial differences found in urine of healthy women and women with overactive bladder

Bacteria live in the bladders of healthy women, discrediting the common belief that normal urine is sterile. Continue reading

Looking ‘inside the box’ for sustainable solution for intestinal parasites

Looking ‘inside the box’ for sustainable solution for intestinal parasites

According to the World Health Organization, more than 450 million people worldwide, primarily children and pregnant women, suffer illness from soil-transmitted helminths (STH), intestinal parasites that live in humans and other animals. Considerable effort and resources have been, and continue to be, spent on top-down, medical-based programs focused on administering drugs to control STH infections, with little success. John Hawdon, Ph.D., associate professor of microbiology, immunology, and tropical medicine at the George Washington University School of Medicine and Health Sciences, advocates a more sustainable solution for controlling STH infections. Continue reading

Soy sauce molecule may unlock drug therapy for HIV patients

Soy sauce molecule may unlock drug therapy for HIV patients

For HIV patients being treated with anti-AIDS medications, resistance to drug therapy regimens is commonplace. Often, patients develop resistance to first-line drug therapies, such as Tenofovir, and are forced to adopt more potent medications. Virologists at the University of Missouri now are testing the next generation of medications that stop HIV from spreading, and are using a molecule related to flavor enhancers found in soy sauce, to develop compounds that are more potent than Tenofovir Continue reading

One cell type may quash tumor vaccines

One cell type may quash tumor vaccines

Most cancer vaccines have not lived up to their promise in clinical trials. The reason, many researchers suspect, is that the immune cells that would help the body destroy the tumor — even those reactions boosted by cancer vaccines — are actively suppressed. Now, researchers at Thomas Jefferson University have found that a single cell type is actively suppressed in several experimental cancer vaccines, paving the way toward methods to break suppression and improve the effectiveness of cancer vaccines Continue reading

Fight memory loss with a smile (or chuckle)

Fight memory loss with a smile (or chuckle)

Too much stress can take its toll on the body, mood, and mind. As we age it can contribute to a number of health problems, including high blood pressure, diabetes, and heart disease. Recent research has shown that the stress hormone cortisol damages certain neurons in the brain and can negatively affect memory and learning ability in the elderly. Continue reading

Rural microbes could boost city dwellers’ health, study finds

Rural microbes could boost city dwellers’ health, study finds

The greater prevalence of asthma, allergies and other chronic inflammatory disorders among people of lower socioeconomic status might be due in part to their reduced exposure to the microbes that thrive in rural environments, according to a new scientific paper co-authored by a University of Colorado Boulder researcher. The article, published in the journal Clinical & Experimental Immunology , argues that people living in urban centers who have less access to green spaces may be more apt to have chronic inflammation, a condition caused by immune system dysfunction Continue reading

Finding safe drugs to treat neurodegenerative diseases

Finding safe drugs to treat neurodegenerative diseases

People diagnosed with Huntington’s disease, most in their mid-thirties and forties, face a devastating prognosis: complete mental, physical, and behavioral decline within two decades. “Mutant” protein clusters, long blamed for the progression of the genetic disease, have been the primary focus of therapies in development by pharmaceutical companies Continue reading

Mom’s diet mirrors child’s food allergies

Mom’s diet mirrors child’s food allergies

A long-term study evaluating maternal diet’s impact on food allergy in later life is expected to uncover causes of allergy in children. About 20 million Europeans are subject to food allergies. Continue reading