List/Grid

Molecular Biology Subscribe to Molecular Biology

Mimicking natural evolution with ‘promiscuous reactions’ to improve the diversity of drugs

Mimicking natural evolution with ‘promiscuous reactions’ to improve the diversity of drugs

The researchers, who report their findings online in the journal Nature Chemistry , took their inspiration from evolution in nature. The research may uncover new pharmaceutical drugs that traditional methods would never have found. “Nature produces some amazing structures with really interesting biological activity, but the plant or animal did not design them. Continue reading

Some anti-inflammatory drugs affect more than their targets

Some anti-inflammatory drugs affect more than their targets

Researchers have discovered that three commonly used nonsteroidal anti-inflammatory drugs, or NSAIDs, alter the activity of enzymes within cell membranes. Their finding suggests that, if taken at higher-than-approved doses and/or for long periods of time, these prescription-level NSAIDs and other drugs that affect the membrane may produce wide-ranging and unwanted side effects. More positively, the researchers say, their work provides the basis for a test that drug developers can use to predict and perhaps avoid these side effects in new medicines they make Continue reading

New ways to treat solid tumors using protein

New ways to treat solid tumors using protein

An international team of scientists has shown that an antibody against the protein EphA3, found in the micro-environment of solid cancers, has anti-tumor effects. As EphA3 is present in normal organs only during embryonic development but is expressed in blood cancers and in solid tumors, this antibody-based approach may be a suitable candidate treatment for solid tumors. The researchers from Monash University and Ludwig Cancer Research, in Australia, and KaloBios Pharmaceuticals, in the US, have had their findings published in the journal Cancer Research . Continue reading

Mystery of brain cell growth unraveled by scientists

Mystery of brain cell growth unraveled by scientists

In the developing brain, special proteins that act like molecular tugboats push or pull on growing nerve cells, or neurons, helping them navigate to their assigned places amidst the brain’s wiring. How a single protein can exert both a push and a pull force to nudge a neuron in the desired direction is a longstanding mystery that has now been solved by scientists from Dana-Farber Cancer Institute and collaborators in Europe and China. Jia-huai Wang, PhD, who led the work at Dana-Farber and Peking University in Beijing, is a corresponding author of a report published in the August 7 online edition of Neuron that explains how one guidance protein, netrin-1, can either attract or repel a brain cell to steer it along its course. Continue reading

Hybrid-motor helps cells push their way through tissues

Hybrid-motor helps cells push their way through tissues

Research has uncovered how two cellular motors, previously thought to compete with each other, can actually work together to help cells squeezing through a crowded mass of cells. Continue reading

Genetic cause of common breast tumors found

Genetic cause of common breast tumors found

A multi-disciplinary team of scientists from the National Cancer Centre Singapore, Duke-NUS Graduate Medical School Singapore, and Singapore General Hospital have made a major breakthrough in understanding the molecular basis of fibroadenoma, one of the most common breast tumors diagnosed in women. Continue reading

Scientists map one of most important proteins in life — and cancer

Scientists map one of most important proteins in life — and cancer

Scientists reveal the structure of one of the most important and complicated proteins in cell division — a fundamental process in life and the development of cancer — in research published in Nature . Continue reading

New technology for diagnosis of cancer cells

New technology for diagnosis of cancer cells

The type of therapy a cancer patient receives, largely depends on the trained eye of a pathologist. Investigating diseased organs and tissues under the microscope is one of their tasks. However, human judgment is, by its very nature, subject to a certain degree of variation Continue reading

Alzheimer’s linked to brain hyperactivity

Alzheimer’s linked to brain hyperactivity

Patients with Alzheimer’s disease run a high risk of seizures. While the amyloid-beta protein involved in the development and progression of Alzheimer’s seems the most likely cause for this neuronal hyperactivity, how and why this elevated activity takes place hasn’t yet been explained — until now. A new study by Tel Aviv University researchers, published in Cell Reports , pinpoints the precise molecular mechanism that may trigger an enhancement of neuronal activity in Alzheimer’s patients, which subsequently damages memory and learning functions Continue reading

Gut microbe levels are linked to type 2 diabetes and obesity

Gut microbe levels are linked to type 2 diabetes and obesity

People with Type 2 diabetes or obesity have changes in the composition of their intestinal micro-organisms — called the gut microbiota — that healthy people do not have, researchers from Turkey have found. They presented the results Sunday at the joint meeting of the International Society of Endocrinology and the Endocrine Society: ICE/ENDO 2014 in Chicago. Continue reading