List/Grid

Basic Sciences Subscribe to Basic Sciences

Scientists find way to trap, kill malaria parasite

Scientists find way to trap, kill malaria parasite

Scientists may be able to entomb the malaria parasite in a prison of its own making, researchers at Washington University School of Medicine in St. Louis report July 16 in Nature Continue reading

Scientists find way to trap, kill malaria parasite

Scientists find way to trap, kill malaria parasite

Scientists may be able to entomb the malaria parasite in a prison of its own making, researchers at Washington University School of Medicine in St. Louis report July 16 in Nature Continue reading

Drug’s effect on Alzheimer’s may depend on severity of disease

Drug’s effect on Alzheimer’s may depend on severity of disease

A cancer drug that has shown promise against Alzheimer’s disease (AD) in mice and has begun early clinical trials has yielded perplexing results in a novel mouse model of AD that mimics the genetics and pathology of the human disease more closely than any other animal model. The drug, bexarotene, was found to reduce levels of the neurotoxic protein amyloid-beta in experimental mice with late-stage Alzheimer’s but to increase levels during early stages of disease. The finding, by researchers at the University of Illinois at Chicago College of Medicine, was reported July 16 at the Alzheimer’s Association International Conference in Copenhagen by Mary Jo LaDu, who in 2012 developed a transgenic mouse that is now regarded as the best animal model of the human disease. Continue reading

Cholesterol-lowering drugs may reduce cardiovascular death in type 2 diabetes

Cholesterol-lowering drugs may reduce cardiovascular death in type 2 diabetes

Heart disease and stroke are the leading causes of death and disability among people with Type 2 diabetes. In fact, at least 65 percent of people with diabetes die from some form of heart disease or stroke, according to the American Heart Association. However, a new study by researchers at Wake Forest Baptist Medical Center suggests that the use of cholesterol-lowering statins may help prolong the lives of people with diabetic cardiovascular disease. Continue reading

Immune response to infectious disease: New findings on properdin

Immune response to infectious disease: New findings on properdin

University of Leicester researchers — including three PhD graduates — contribute significantly to knowledge in immunology University of Leicester researchers have released evidence substantiating an unexpected dual role of an important component of the immune system. Findings by researchers at the University’s Department of Infection, Immunity and Inflammation — including three PhD graduates — are published in a paper for the journal ‘Medical Microbiology and Immunology’ Continue reading

Immune response to infectious disease: New findings on properdin

Immune response to infectious disease: New findings on properdin

University of Leicester researchers — including three PhD graduates — contribute significantly to knowledge in immunology University of Leicester researchers have released evidence substantiating an unexpected dual role of an important component of the immune system. Findings by researchers at the University’s Department of Infection, Immunity and Inflammation — including three PhD graduates — are published in a paper for the journal ‘Medical Microbiology and Immunology’ Continue reading

Mutation stops worms from getting drunk

Mutation stops worms from getting drunk

Neuroscientists at The University of Texas at Austin have generated mutant worms that do not get intoxicated by alcohol, a result that could lead to new drugs to treat the symptoms of people going through alcohol withdrawal. The scientists accomplished this feat by inserting a modified human alcohol target into the worms, as reported this week in The Journal of Neuroscience . Continue reading

Preventing heart disease in New York City children and their caregivers

Preventing heart disease in New York City children and their caregivers

Mount Sinai Heart at Icahn School of Medicine at Mount Sinai has been awarded a $3.8 million grant by the American Heart Association (AHA) to promote cardiovascular health among high-risk New York City children, and their parents, living in Harlem and the Bronx. With assistance from the NYC Administration for Children’s Services (ACS), the research team’s mission is to reduce each child’s future risk of obesity, heart attack, stroke, and type 2 diabetes Continue reading

Prostate cancer in young men: More frequent, more aggressive?

Prostate cancer in young men: More frequent, more aggressive?

The number of younger men diagnosed with prostate cancer has increased nearly 6-fold in the last 20 years, and the disease is more likely to be aggressive in these younger men, according to a new analysis from researchers at the University of Michigan Comprehensive Cancer Center. Continue reading

Likely origin of lung fungus invading Pacific Northwest found by study

Likely origin of lung fungus invading Pacific Northwest found by study

Cryptococcus gattii , a virulent fungus that has invaded the Pacific Northwest is highly adaptive and warrants global “public health vigilance,” according to a study by an international team led by the Translational Genomics Research Institute (TGen). C. gattii , which likely originated in Brazil, is responsible for dozens of deaths in recent years since it was first found in 1999 on Vancouver Island, British Columbia, Canada, well outside its usual tropical habitats Continue reading