List/Grid

Basic Sciences Subscribe to Basic Sciences

Hormone therapy linked to lower non-Hodgkin lymphoma risk

Hormone therapy linked to lower non-Hodgkin lymphoma risk

Hormone therapy, which is prescribed to women for relief of menopausal symptoms such hot flashes, night sweats and vaginal dryness, has recently seen a decline in popularity (and use) due to its link to an increased risk of breast and endometrial cancer. But City of Hope researchers have found that menopausal hormone therapy may actually lower the risk of B-cell non-Hodgkin lymphoma. Sophia Wang, Ph.D., associate professor at City of Hope’s Division of Cancer Etiology and first author of this study, will present the findings at the American Association for Cancer Research (AACR) annual meeting on Monday, April 7. Continue reading

Seeing double: New study explains evolution of duplicate genes

Seeing double: New study explains evolution of duplicate genes

From time to time, living cells will accidentally make an extra copy of a gene during the normal replication process. Throughout the history of life, evolution has molded some of these seemingly superfluous genes into a source of genetic novelty, adaptation and diversity Continue reading

Seeing double: New study explains evolution of duplicate genes

Seeing double: New study explains evolution of duplicate genes

From time to time, living cells will accidentally make an extra copy of a gene during the normal replication process. Throughout the history of life, evolution has molded some of these seemingly superfluous genes into a source of genetic novelty, adaptation and diversity Continue reading

Hope for children with previously incurable brain cancer

Hope for children with previously incurable brain cancer

Imagine the anguish of a parent whose child is diagnosed with an incurable form of childhood brain cancer. Surgery is not an option, current chemotherapy is ineffective and focal radiation only provides temporary relief. Remarkably, researchers from the Department of Laboratory Medicine and Pathobiology (LMP) have defined potential treatment targets for this relatively common cancer — providing hope for future patients Continue reading

Hope for children with previously incurable brain cancer

Hope for children with previously incurable brain cancer

Imagine the anguish of a parent whose child is diagnosed with an incurable form of childhood brain cancer. Continue reading

Tissue testing during breast cancer lumpectomies prevents need for reoperation 96 percent of time

Tissue testing during breast cancer lumpectomies prevents need for reoperation 96 percent of time

Unique laboratory testing during breast cancer lumpectomies to make sure surgeons remove all cancerous tissue spares patients the need for a repeat lumpectomy in roughly 96 percent of cases at Mayo Clinic in Rochester, a success rate much higher than the rate nationally, a Mayo study shows. During the years reviewed, 13.2 percent of breast cancer lumpectomy patients nationally had to return to the operating room within a month of their initial surgery, compared to 3.6 percent at Mayo in Rochester, which uses a technique called frozen section analysis to test excised tissue for cancer while patient are still on the operating table. Continue reading

Tissue testing during breast cancer lumpectomies prevents need for reoperation 96 percent of time

Tissue testing during breast cancer lumpectomies prevents need for reoperation 96 percent of time

Unique laboratory testing during breast cancer lumpectomies to make sure surgeons remove all cancerous tissue spares patients the need for a repeat lumpectomy in roughly 96 percent of cases at Mayo Clinic in Rochester, a success rate much higher than the rate nationally, a Mayo study shows. During the years reviewed, 13.2 percent of breast cancer lumpectomy patients nationally had to return to the operating room within a month of their initial surgery, compared to 3.6 percent at Mayo in Rochester, which uses a technique called frozen section analysis to test excised tissue for cancer while patient are still on the operating table. Continue reading

Disruption of VISTA plays an important role in regulating immune response

Disruption of VISTA plays an important role in regulating immune response

Date: April 7, 2014 Source: Norris Cotton Cancer CenterDartmouth-Hitchcock Medical Center Summary: The body’s immune system response was enhanced in a study when researchers disrupted VISTA, a protein that prevents the immune system from overreacting. Understanding how checkpoint regulators like VISTA function is important to cancer researchers, who hope to use the immune system to attack tumors. Researchers at the Geisel School of Medicine at Dartmouth have found that the body’s immune system response was enhanced when they disrupted VISTA, a protein that prevents the immune system from overreacting Continue reading

Disruption of VISTA plays an important role in regulating immune response

Disruption of VISTA plays an important role in regulating immune response

Date: April 7, 2014 Source: Norris Cotton Cancer CenterDartmouth-Hitchcock Medical Center Summary: The body’s immune system response was enhanced in a study when researchers disrupted VISTA, a protein that prevents the immune system from overreacting. Understanding how checkpoint regulators like VISTA function is important to cancer researchers, who hope to use the immune system to attack tumors. Continue reading

Gene sequencing project discovers mutations tied to deadly brain tumors in young children

Gene sequencing project discovers mutations tied to deadly brain tumors in young children

The St. Jude Children’s Research Hospital-Washington University Pediatric Cancer Genome Project has identified new mutations in pediatric brain tumors known as high-grade gliomas (HGGs), which most often occur in the youngest patients Continue reading