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Intestinal bacteria needed for strong flu vaccine responses in mice

Intestinal bacteria needed for strong flu vaccine responses in mice

Mice treated with antibiotics to remove most of their intestinal bacteria or raised under sterile conditions have impaired antibody responses to seasonal influenza vaccination, researchers have found. The findings suggest that antibiotic treatment before or during vaccination may impair responses to certain vaccines in humans Continue reading

Intestinal bacteria needed for strong flu vaccine responses in mice

Intestinal bacteria needed for strong flu vaccine responses in mice

Mice treated with antibiotics to remove most of their intestinal bacteria or raised under sterile conditions have impaired antibody responses to seasonal influenza vaccination, researchers have found. Continue reading

New payment model for gene therapy needed, experts say

New payment model for gene therapy needed, experts say

Hoping to encourage sufficient investments by pharmaceutical companies in expensive gene therapies, which often consist of a single treatment, a Penn researcher and the chief medical officer of CVS Health outline an alternative payment model in this month’s issue of Nature Biotechnology . They suggest annuity payments over a defined period of time and contingent on evidence that the treatment remains effective Continue reading

Disease in a dish approach could aid Huntington’s disease discovery

Disease in a dish approach could aid Huntington’s disease discovery

Creating induced pluripotent stem cells or iPS cells allows researchers to establish “disease in a dish” models of conditions ranging from Alzheimer’s disease to diabetes. Scientists at Yerkes National Primate Research Center, Emory University have now applied the technology to a model of Huntington’s disease (HD) in transgenic nonhuman primates, allowing them to conveniently assess the efficacy of potential therapies on neuronal cells in the laboratory. Continue reading

Banked blood grows stiffer with age, study finds

Banked blood grows stiffer with age, study finds

It may look like fresh blood and flow like fresh blood, but the longer blood is stored, the less it can carry oxygen into the tiny microcapillaries of the body, says a new study from University of Illinois researchers. Using advanced optical techniques, the researchers measured the stiffness of the membrane surrounding red blood cells over time Continue reading

New gene mutations for Wilms tumor found

New gene mutations for Wilms tumor found

Researchers at UT Southwestern Medical Center and the Gill Center for Cancer and Blood Disorders at Children’s Medical Center, Dallas, have made significant progress in defining new genetic causes of Wilms tumor, a type of kidney cancer found only in children. Wilms tumor is the most common childhood genitourinary tract cancer and the third most common solid tumor of childhood Continue reading

Rare stem cells hold potential for infertility treatments

Rare stem cells hold potential for infertility treatments

Rare stem cells in testis that produce a biomarker protein called PAX7 help give rise to new sperm cells — and may hold a key to restoring fertility, research by scientists at UT Southwestern Medical Center suggests. Continue reading

Insights into severe form of dwarfism

Insights into severe form of dwarfism

A better understanding of the pathology of a severe form of dwarfism as well as a possible window of treatment have been discovered by researchers at The University of Texas Health Science Center at Houston (UTHealth). The preclinical research was published in a recent issue of the Journal of Bone and Mineral Research Continue reading

Novel treatment strengthens bones in genetic disease neurofibromatosis type-1

Novel treatment strengthens bones in genetic disease neurofibromatosis type-1

An enzyme therapy may prevent skeletal abnormalities associated with the genetic disorder neurofibromatosis type-1, Vanderbilt investigators have discovered. The researchers demonstrated in a mouse model of the disorder that the enzyme asfotase-alpha improves bone growth, mineralization and strength. Continue reading

Tests to Diagnose Invasive Aspergillosis with 100% Accuracy

Tests to Diagnose Invasive Aspergillosis with 100% Accuracy

The fungal infection invasive aspergillosis (IA) can be life threatening, especially in patients whose immune systems are weakened by chemotherapy or immunosuppressive drugs. Despite the critical need for early detection, IA remains difficult to diagnose. A study in The Journal of Molecular Diagnostics compared three diagnostic tests and found that the combination of nucleic acid sequence-based amplification (NASBA) and real-time quantitative PCR (qPCR) detects aspergillosis with 100% accuracy. Continue reading