List/Grid

Pathology Subscribe to Pathology

Poor coverage of specific gene sets in exome sequencing gives cause for concern

Poor coverage of specific gene sets in exome sequencing gives cause for concern

With services based on exome sequencing becoming affordable to patients at a reasonable price, the question of the quality of the results provided has become increasingly important. The exome is the DNA sequence of genes that are translated into protein. Continue reading

How breast cancer ‘expresses itself’

How breast cancer ‘expresses itself’

About one in eight women in the United States will contract breast cancer in her lifetime. Now new research from Tel Aviv University-affiliated researchers, in collaboration with Johns Hopkins University, has provided another tool to help women, clinicians, and scientists searching for a cure to the one of the most widespread yet incurable diseases on the planet. Dr Continue reading

Extensive cataloging of human proteins uncovers 193 never known to exist

Extensive cataloging of human proteins uncovers 193 never known to exist

Striving for the protein equivalent of the Human Genome Project, an international team of researchers has created an initial catalog of the human “proteome,” or all of the proteins in the human body. Continue reading

Major discovery on the mechanism of drug resistance in leukemia and other cancers

Major discovery on the mechanism of drug resistance in leukemia and other cancers

A mechanism that enables the development of resistance to Acute Myeloid Leukemia (AML) anticancer drugs, thereby leading to relapse, has been identified by Kathy Borden of the University of Montreal’s Institute for Research in Immunology and Cancer (IRIC) and her collaborators. Kathy Borden is a Principal Investigator at IRIC and a professor at the university’s Department of Pathology and Cell Biology. Continue reading

Promising new target for gum disease treatment identified

Promising new target for gum disease treatment identified

Nearly half of all adults in the United States suffer from the gum disease periodontitis, and 8.5 percent have a severe form that can raise the risk of heart disease, diabetes, arthritis and pregnancy complications. University of Pennsylvania researchers have been searching for ways to prevent, half and reverse periodontitis. In a report published in the Journal of Immunology , they describe a promising new target: a component of the immune system called complement Continue reading

Molecules involved in rheumatoid arthritis angiogenesis identified

Molecules involved in rheumatoid arthritis angiogenesis identified

Two protein molecules that fit together as lock and key seem to promote the abnormal formation of blood vessels in joints affected by rheumatoid arthritis, according to researchers at the University of Illinois at Chicago College of Medicine, who found that the substances are present at higher levels in the joints of patients affected by the disease. Their results are reported in the journal Annals of the Rheumatic Diseases . “Our results show, for the first time, that these two proteins — a receptor and its corresponding binding protein — play a key role in the progression of rheumatoid arthritis pathology,” said Shiva Shahrara, associate professor of rheumatology at UIC. Continue reading

Role of calcium in familial Alzheimer’s disease clarified, pointing to new therapeutics

Role of calcium in familial Alzheimer’s disease clarified, pointing to new therapeutics

In 2008 researchers at the Perelman School of Medicine at the University of Pennsylvania showed that mutations in two proteins associated with familial Alzheimer’s disease (FAD) disrupt the flow of calcium ions within neurons. Continue reading

Novel protein fragments may protect against Alzheimer’s

Novel protein fragments may protect against Alzheimer’s

The devastating loss of memory and consciousness in Alzheimer’s disease is caused by plaque accumulations and tangles in neurons, which kill brain cells. Alzheimer’s research has centered on trying to understand the pathology as well as the potential protective or regenerative properties of brain cells as an avenue for treating the widespread disease. Continue reading

Cause of many preterm births discovered: Premature aging of placenta from oxidative stress

Cause of many preterm births discovered: Premature aging of placenta from oxidative stress

A new study by researchers at the University of Texas Medical Branch at Galveston is the first to show that premature aging of the placenta due to oxidative stress is the cause of many preterm births. The study appears today in the American Journal of Pathology. Continue reading

Association between small-vessel disease, Alzheimer pathology studied

Association between small-vessel disease, Alzheimer pathology studied

Cerebral small-vessel disease (SVD) and Alzheimer disease (AD) pathology appear to be associated. Continue reading