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New genome-editing platform significantly increases accuracy of CRISPR-based systems

New genome-editing platform significantly increases accuracy of CRISPR-based systems

A next-generation genome editing system developed by Massachusetts General Hospital (MGH) investigators substantially decreases the risk of producing unwanted, off-target gene mutations. In a paper receiving online publication in Nature Biotechnology , the researchers report a new CRISPR-based RNA-guided nuclease technology that uses two guide RNAs, significantly reducing the chance of cutting through DNA strands at mismatched sites. “This system combines the ease of use of the widely adopted CRISPR/Cas system with a dimerization-dependent nuclease activity that confers higher specificity of action,” says J. Continue reading

New genome-editing platform significantly increases accuracy of CRISPR-based systems

New genome-editing platform significantly increases accuracy of CRISPR-based systems

A next-generation genome editing system developed by Massachusetts General Hospital (MGH) investigators substantially decreases the risk of producing unwanted, off-target gene mutations. In a paper receiving online publication in Nature Biotechnology , the researchers report a new CRISPR-based RNA-guided nuclease technology that uses two guide RNAs, significantly reducing the chance of cutting through DNA strands at mismatched sites. “This system combines the ease of use of the widely adopted CRISPR/Cas system with a dimerization-dependent nuclease activity that confers higher specificity of action,” says J. Continue reading

Finding safe drugs to treat neurodegenerative diseases

Finding safe drugs to treat neurodegenerative diseases

People diagnosed with Huntington’s disease, most in their mid-thirties and forties, face a devastating prognosis: complete mental, physical, and behavioral decline within two decades. “Mutant” protein clusters, long blamed for the progression of the genetic disease, have been the primary focus of therapies in development by pharmaceutical companies Continue reading

New target for prostate cancer resistant to anti-hormone therapies

New target for prostate cancer resistant to anti-hormone therapies

Prostate cancer becomes deadly when anti-hormone treatments stop working. Now a new study suggests a way to block the hormones at their entrance Continue reading

New patenting guidelines needed for biotechnology

New patenting guidelines needed for biotechnology

Biotechnology scientists must be aware of the broad patent landscape and push for new patent and licensing guidelines, according to a new paper from Rice University’s Baker Institute for Public Policy. Published in the current issue of the journal Regenerative Medicine , the paper is based on the June 2013 U.S Continue reading

Why alcoholism saps muscle strength

Why alcoholism saps muscle strength

Muscle weakness is a common symptom of both long-time alcoholics and patients with mitochondrial disease. Continue reading

MRI pinpoints region of brain injury in some concussion patients

MRI pinpoints region of brain injury in some concussion patients

Researchers using information provided by a magnetic resonance imaging (MRI) technique have identified regional white matter damage in the brains of people who experience chronic dizziness and other symptoms after concussion. The findings suggest that information provided by MRI can speed the onset of effective treatments for concussion patients. The results of this research are published online in the journal Radiology Continue reading

MRI pinpoints region of brain injury in some concussion patients

MRI pinpoints region of brain injury in some concussion patients

Researchers using information provided by a magnetic resonance imaging (MRI) technique have identified regional white matter damage in the brains of people who experience chronic dizziness and other symptoms after concussion. The findings suggest that information provided by MRI can speed the onset of effective treatments for concussion patients. The results of this research are published online in the journal Radiology Continue reading

Experimental blood test spots recurrent breast cancers, monitors response to treatment

Experimental blood test spots recurrent breast cancers, monitors response to treatment

Johns Hopkins Kimmel Cancer Center investigators report they have designed a blood test that accurately detects the presence of advanced breast cancer and also holds promise for precisely monitoring response to cancer treatment. Continue reading

Fiber-optic microscope will help physicians detect cancer, diseases at early stages

Fiber-optic microscope will help physicians detect cancer, diseases at early stages

An engineering researcher at the University of Arkansas has developed an inexpensive, endoscopic microscope capable of producing high-resolution, sub-cellular images of tissue in real time. The fiber-optic device, which is portable, re-usable and easily packaged with conventional endoscopes, will help clinicians detect and diagnose early-stage disease, primarily cancer. Continue reading