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Described novel regulator of protein inactive in over 50 percent of human tumors

Described novel regulator of protein inactive in over 50 percent of human tumors

Researchers at the Bellvitge Biomedical Research Institute (IDIBELL) and the University of Barcelona have discovered the interaction between HERC2 proteins with another protein called p53 that is inactivated in more than half of human tumors. The study results were published in the Journal of Biological Chemistry. Regulation of the activity of p53 by HERC2 The team of José Luis Rosa, at the growth factors and cell differentiation research group at IDIBELL studies the molecular mechanisms of HERC family proteins. Continue reading

Described novel regulator of protein inactive in over 50 percent of human tumors

Described novel regulator of protein inactive in over 50 percent of human tumors

Researchers at the Bellvitge Biomedical Research Institute (IDIBELL) and the University of Barcelona have discovered the interaction between HERC2 proteins with another protein called p53 that is inactivated in more than half of human tumors. The study results were published in the Journal of Biological Chemistry. Continue reading

Scientists map one of most important proteins in life — and cancer

Scientists map one of most important proteins in life — and cancer

Scientists reveal the structure of one of the most important and complicated proteins in cell division — a fundamental process in life and the development of cancer — in research published in Nature . Continue reading

New cellular garbage control pathway with relevance for human neurodegenerative diseases

New cellular garbage control pathway with relevance for human neurodegenerative diseases

Several human neurodegenerative diseases, including Alzheimer’s, Parkinson’s and Huntington’s disease but also aging, are linked to an accumulation of abnormal and aggregated proteins in cells. Cellular “garbage” of this type can be removed from cells by sweeping them to a cellular recycling station known as the lysosome Continue reading

Adolescent alcohol abuse disrupts transitions into early adulthood

Adolescent alcohol abuse disrupts transitions into early adulthood

Prior research has shown strong associations between adolescent alcohol abuse and adverse outcomes in early adulthood. A first-of-its-kind study of linkages between adolescent alcohol abuse and adverse adult outcomes has examined the influence of differences in familial background and shared genetics on this association; findings are consistent with a causal relationship between adolescent drinking and subsequent alcohol-related adult problems that cannot be fully explained by shared genetic and environmental liabilities. Results will be published in the August 2014 online-only issue of Alcoholism: Clinical & Experimental Research and are currently available at Early View Continue reading

Transplanting gene into injured hearts creates biological pacemakers

Transplanting gene into injured hearts creates biological pacemakers

Cardiologists at the Cedars-Sinai Heart Institute have developed a minimally invasive gene transplant procedure that changes unspecialized heart cells into “biological pacemaker” cells that keep the heart steadily beating. The laboratory animal research, published online and in today’s print edition of the peer-reviewed journal Science Translational Medicine , is the result of a dozen years of research with the goal of developing biological treatments for patients with heart rhythm disorders who currently are treated with surgically implanted pacemakers. Continue reading

Anti-tank missile detector joins fight against malaria

Anti-tank missile detector joins fight against malaria

State-of-the-art military hardware could soon fight malaria, one of the most deadly diseases on the planet. Researchers at Monash University and the University of Melbourne have used an anti-tank Javelin missile detector, more commonly used in warfare to detect the enemy, in a new test to rapidly identify malaria parasites in blood. Scientists say the novel idea, published in the journal Analyst , could set a new gold standard for malaria testing Continue reading

Effects of starvation can be passed to future generations, through small RNAs apparently without DNA involvement

Effects of starvation can be passed to future generations, through small RNAs apparently without DNA involvement

Evidence from human famines and animal studies suggests that starvation can affect the health of descendants of famished individuals. But how such an acquired trait might be transmitted from one generation to the next has not been clear Continue reading

Humans walking on all fours is not backward evolution

Humans walking on all fours is not backward evolution

Contradicting earlier claims, “The Family That Walks on All Fours,” a group of quadrupedal humans made famous by a 2006 BBC documentary, have simply adapted to their inability to walk upright and do not represent an example of backward evolution, according to new research by Liza Shapiro, an anthropologist at The University of Texas at Austin. Five siblings in the family, who live in a remote corner of Turkey, walk exclusively on their hands and feet. Since they were discovered in 2005, scientists have debated the nature of their disability, with speculation they represent a backward stage of evolution Continue reading

Humans walking on all fours is not backward evolution

Humans walking on all fours is not backward evolution

Contradicting earlier claims, “The Family That Walks on All Fours,” a group of quadrupedal humans made famous by a 2006 BBC documentary, have simply adapted to their inability to walk upright and do not represent an example of backward evolution, according to new research by Liza Shapiro, an anthropologist at The University of Texas at Austin. Five siblings in the family, who live in a remote corner of Turkey, walk exclusively on their hands and feet. Since they were discovered in 2005, scientists have debated the nature of their disability, with speculation they represent a backward stage of evolution Continue reading