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Prototype electrolyte sensor to provide immediate read-outs: Painless wearable microneedle device may reduce trips to doctors’ offices

Prototype electrolyte sensor to provide immediate read-outs: Painless wearable microneedle device may reduce trips to doctors’ offices

Patients trying to navigate today’s complex medical system with its costly laboratory analyses might prefer a pain-free home diagnostic device, worn on the wrist, that can analyze, continuously record and immediately remedy low electrolyte levels. Continue reading

Humans’ tiny cellular machines: Spliceosomes in detail

Humans’ tiny cellular machines: Spliceosomes in detail

A grandfather clock is, on its surface, a simple yet elegant machine. Tall and stately, its job is to steadily tick away the time. Continue reading

Subtle change in DNA, protein levels determines blond or brunette tresses, study finds

Subtle change in DNA, protein levels determines blond or brunette tresses, study finds

A molecule critical to stem cell function plays a major role in determining human hair color, according to a study from the Stanford University School of Medicine. The study describes for the first time the molecular basis for one of our most noticeable traits. Continue reading

Poor coverage of specific gene sets in exome sequencing gives cause for concern

Poor coverage of specific gene sets in exome sequencing gives cause for concern

With services based on exome sequencing becoming affordable to patients at a reasonable price, the question of the quality of the results provided has become increasingly important. The exome is the DNA sequence of genes that are translated into protein. Continue reading

Responses with crizotinib in MET-amplified lung cancer show new targetable form of disease

Responses with crizotinib in MET-amplified lung cancer show new targetable form of disease

A study presented at the American Society of Clinical Oncology (ASCO) Annual Meeting 2014 reports the results of a first-in-human, phase 1 dose escalation trial of crizotinib (XALKORI) in 14 patients with advanced, MET-amplified non-small cell lung cancer (NCT00585195). In 2011, the drug crizotinib earned accelerated approval by the US FDA to target the subset of advanced non-small cell lung cancers caused by rearrangements of the anaplastic lymphoma kinase (ALK) gene, and subsequently was granted regular approval in 2013 Continue reading

Researchers see stem cells take key step toward development: A first

Researchers see stem cells take key step toward development: A first

The gap between stem cell research and regenerative medicine just became a lot narrower, thanks to a new technique that coaxes stem cells, with potential to become any tissue type, to take the first step to specialization. It is the first time this critical step has been demonstrated in a laboratory. University of Illinois researchers, in collaboration with scientists at Notre Dame University and the Huazhong University of Science and Technology in China, published their results in the journal Nature Communications Continue reading

New clinical guidelines for cancer-related fatigue

New clinical guidelines for cancer-related fatigue

Fatigue is a debilitating problem for cancer patients undergoing treatment; however, it also poses a huge detriment after treatment and can significantly affect quality of life. Approximately 30 percent of cancer patients endure persistent fatigue for several years after treatment, according to an American Society of Clinical Oncology Expert Panel co-chaired by Paul Jacobsen, Ph.D., associate center director of Population Sciences at Moffitt Cancer Center. ASCO created the panel to develop assessment, screening, and treatment guidelines for medical professionals to help patients who experience fatigue after completing primary treatment.The panel analyzed several national guidelines from the United States and Canada, and reviewed published studies about cancer-related fatigue to create the new guidelines. Continue reading

Eating prunes can help weight loss, study shows

Eating prunes can help weight loss, study shows

Research by the University of Liverpool has found that eating prunes as part of a weight control diet can improve weight loss. Consumption of dried fruit is not readily recommended during weight loss despite evidence it enhances feelings of fullness Continue reading

Tool to better screen, treat aneurysm patients

Tool to better screen, treat aneurysm patients

New research by an international consortium, including a researcher from Lawrence Livermore National Laboratory, may help physicians better understand the chronological development of a brain aneurysm. Using radiocarbon dating to date samples of ruptured and unruptured cerebral aneurysm (CA) tissue, the team, led by neurosurgeon Nima Etminan, found that the main structural constituent and protein — collagen type I — in cerebral aneurysms is distinctly younger than once thought Continue reading

How breast cancer ‘expresses itself’

How breast cancer ‘expresses itself’

About one in eight women in the United States will contract breast cancer in her lifetime. Now new research from Tel Aviv University-affiliated researchers, in collaboration with Johns Hopkins University, has provided another tool to help women, clinicians, and scientists searching for a cure to the one of the most widespread yet incurable diseases on the planet. Dr Continue reading