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One injection stops diabetes in its tracks: Treatment reverses symptoms of type 2 diabetes in mice without side effects

One injection stops diabetes in its tracks: Treatment reverses symptoms of type 2 diabetes in mice without side effects

In mice with diet-induced diabetes — the equivalent of type 2 diabetes in humans — a single injection of the protein FGF1 is enough to restore blood sugar levels to a healthy range for more than two days. The discovery by Salk scientists, published today in the journal Nature , could lead to a new generation of safer, more effective diabetes drugs Continue reading

Health risks posed by ‘third hand’ tobacco smoke

Health risks posed by ‘third hand’ tobacco smoke

Research led by the University of York has highlighted the potential cancer risk in non-smokers — particularly young children — of tobacco smoke gases and particles deposited to surfaces and dust in the home. Until now, the risks of this exposure known as ‘third hand tobacco smoke’ have been highly uncertain and not considered in public policy. However, a new study published in the journal Environment International, has estimated for the first time the potential cancer risk by age group through non-dietary ingestion and dermal exposure to third hand smoke Continue reading

Health risks posed by ‘third hand’ tobacco smoke

Health risks posed by ‘third hand’ tobacco smoke

Research led by the University of York has highlighted the potential cancer risk in non-smokers — particularly young children — of tobacco smoke gases and particles deposited to surfaces and dust in the home. Until now, the risks of this exposure known as ‘third hand tobacco smoke’ have been highly uncertain and not considered in public policy. However, a new study published in the journal Environment International, has estimated for the first time the potential cancer risk by age group through non-dietary ingestion and dermal exposure to third hand smoke Continue reading

New assay to spot fake malaria drugs could save thousands of lives

New assay to spot fake malaria drugs could save thousands of lives

Chemists and students in science and engineering at Oregon State University have created a new type of chemical test, or assay, that’s inexpensive, simple, and can tell whether or not one of the primary drugs being used to treat malaria is genuine — an enormous and deadly problem in the developing world. The World Health Organization has estimated that about 200,000 lives a year may be lost due to the use of counterfeit anti-malarial drugs Continue reading

New combination drug controls tumor growth, metastasis in mice

New combination drug controls tumor growth, metastasis in mice

Researchers at UC Davis, University of Massachusetts and Harvard Medical School have created a combination drug that controls both tumor growth and metastasis. By combining a COX-2 inhibitor, similar to Celebrex, and an epoxide hydrolase (sEH) inhibitor, the drug controls angiogenesis (blood vessel formation), limiting a tumor’s ability to grow and spread. Continue reading

Cause of mysterious food allergy found, new treatment strategy suggested

Cause of mysterious food allergy found, new treatment strategy suggested

New research in Nature Genetics identifies a novel genetic and molecular pathway in the esophagus that causes eosinophillic esophagitis (EoE), opening up potential new therapeutic strategies for an enigmatic and hard-to-treat food allergy. Continue reading

Study of noninvasive retinal imaging device presented at Alzheimer’s conference

Study of noninvasive retinal imaging device presented at Alzheimer’s conference

A noninvasive optical imaging device developed at Cedars-Sinai can provide early detection of changes that later occur in the brain and are a classic sign of Alzheimer’s disease, according to preliminary results from investigators conducting a clinical trial in Australia. The researchers will present their findings July 15 in an oral presentation at the Alzheimer’s Association International Conference 2014 in Copenhagen, Denmark. Continue reading

Stem cell scientists lay TRAP for disease

Stem cell scientists lay TRAP for disease

USC Stem Cell scientists have set a “mouse TRAP” to capture the early signs of kidney failure, as described by a recent study published in the Journal of Clinical Investigation . Their new transgenic mouse line uses a technique called TRAP to extract cellular and genetic information from a variety of solid organs. Invented by scientists at the Rockefeller Institute for Medical Research in 2008, TRAP involves attaching a fluorescent tag to the protein-making machinery, or ribosomes, of the cell type of interest Continue reading

Hydroxyethyl starch has direct harmful effects on kidney cells, lab study finds

Hydroxyethyl starch has direct harmful effects on kidney cells, lab study finds

The increased risk of kidney injury related to the use of hydroxyethyl starch (HES) in resuscitation fluids reflects the mass of HES molecules, according to a report in Anesthesia & Analgesia , official journal of the International Anesthesia Research Society (IARS). The “total mass of HES molecules” explains the harmful effect of HES on cultured human renal proximal tubule cells (PTCs), concludes the laboratory study by Dr Christian Wunder and colleagues of University Hospital Würzburg, Austria. Other factors — such as differences in the origin or molecular weight of HES solutions — appear to play little or no role in cellular-level toxicity of HES. Continue reading

Stem cell researcher targets ‘seeds’ of breast cancer metastasis

Stem cell researcher targets ‘seeds’ of breast cancer metastasis

For breast cancer patients, the era of personalized medicine may be just around the corner, thanks to recent advances by USC Stem Cell researcher Min Yu and scientists at Massachusetts General Hospital and Harvard Medical School. In a July 11 study in Science , Yu and her colleagues report how they isolated breast cancer cells circulating through the blood streams of six patients. Some of these deadly cancer cells are the “seeds” of metastasis, which travel to and establish secondary tumors in vital organs such as the bone, lungs, liver and brain. Continue reading