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Cancer drugs block dementia-linked brain inflammation, study finds

Cancer drugs block dementia-linked brain inflammation, study finds

A class of drugs developed to treat immune-related conditions and cancer — including one currently in clinical trials for glioblastoma and other tumors — eliminates neural inflammation associated with dementia-linked diseases and brain injuries, according to UC Irvine researchers. In their study, assistant professor of neurobiology & behavior Kim Green and colleagues discovered that the drugs, which can be delivered orally, eradicated microglia, the primary immune cells of the brain. These cells exacerbate many neural diseases, including Alzheimer’s and Parkinson’s, as well as brain injury Continue reading

Cancer drugs block dementia-linked brain inflammation, study finds

Cancer drugs block dementia-linked brain inflammation, study finds

A class of drugs developed to treat immune-related conditions and cancer — including one currently in clinical trials for glioblastoma and other tumors — eliminates neural inflammation associated with dementia-linked diseases and brain injuries, according to UC Irvine researchers. In their study, assistant professor of neurobiology & behavior Kim Green and colleagues discovered that the drugs, which can be delivered orally, eradicated microglia, the primary immune cells of the brain. These cells exacerbate many neural diseases, including Alzheimer’s and Parkinson’s, as well as brain injury. Continue reading

HIV-positive women respond well to HPV vaccine, study shows

HIV-positive women respond well to HPV vaccine, study shows

HIV-positive women respond well to a vaccine against the human papillomavirus (HPV), even when their immune system is struggling, according to newly published results of an international clinical trial. Continue reading

Fighting neuroblastomas by blocking DNA replication, repair

Fighting neuroblastomas by blocking DNA replication, repair

Neuroblastoma is one of the deadliest childhood cancers, accounting for 15 percent of pediatric cancer deaths. For patients with high-risk neuroblastomas, the five-year survival rate is 40 to 50 percent even with the most rigorous treatments available today. But those odds may improve soon, thanks to a new compound developed by City of Hope scientists Continue reading

Fighting neuroblastomas by blocking DNA replication, repair

Fighting neuroblastomas by blocking DNA replication, repair

Neuroblastoma is one of the deadliest childhood cancers, accounting for 15 percent of pediatric cancer deaths. For patients with high-risk neuroblastomas, the five-year survival rate is 40 to 50 percent even with the most rigorous treatments available today Continue reading

Body mass index associated with breast cancer, regardless of body shape

Body mass index associated with breast cancer, regardless of body shape

A study of predominantly white women finds a larger waist circumference is associated with higher risk of postmenopausal breast cancer, but not beyond its contribution to BMI. The study, by American Cancer Society researchers, fails to confirm previous findings that body shape itself is an independent risk factor for breast cancer. Continue reading

Body mass index associated with breast cancer, regardless of body shape

Body mass index associated with breast cancer, regardless of body shape

A study of predominantly white women finds a larger waist circumference is associated with higher risk of postmenopausal breast cancer, but not beyond its contribution to BMI. Continue reading

Masculine boys, feminine girls more likely to engage in cancer risk behaviors

Masculine boys, feminine girls more likely to engage in cancer risk behaviors

Young people who conform most strongly to norms of masculinity and femininity — the most “feminine” girls and the most “masculine” boys — are significantly more likely than their peers to engage in behaviors that pose cancer risks, according to a new study led by Harvard School of Public Health (HSPH) researchers. The most feminine teenage girls use tanning beds more frequently and are more likely to be physically inactive, while the most masculine teenage boys are more likely to use chewing tobacco and to smoke cigars, compared with their gender-nonconforming peers. The study, the first to look at cancer risk behaviors in teens based on their gender expression, appears online April 16, 2014 in the Journal of Adolescent Health Continue reading

Masculine boys, feminine girls more likely to engage in cancer risk behaviors

Masculine boys, feminine girls more likely to engage in cancer risk behaviors

Young people who conform most strongly to norms of masculinity and femininity — the most “feminine” girls and the most “masculine” boys — are significantly more likely than their peers to engage in behaviors that pose cancer risks, according to a new study led by Harvard School of Public Health (HSPH) researchers. The most feminine teenage girls use tanning beds more frequently and are more likely to be physically inactive, while the most masculine teenage boys are more likely to use chewing tobacco and to smoke cigars, compared with their gender-nonconforming peers Continue reading

Experimental blood test spots recurrent breast cancers, monitors response to treatment

Experimental blood test spots recurrent breast cancers, monitors response to treatment

Johns Hopkins Kimmel Cancer Center investigators report they have designed a blood test that accurately detects the presence of advanced breast cancer and also holds promise for precisely monitoring response to cancer treatment. Continue reading