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Cetuximab or bevacizumab with combi chemo equivalent in KRAS wild-type MCRC

Cetuximab or bevacizumab with combi chemo equivalent in KRAS wild-type MCRC

For patients with KRAS wild-type untreated colorectal cancer, adding cetuximab or bevacizumab to combination chemotherapy offers equivalent survival, researchers said at the ESMO 16th World Congress on Gastrointestinal Cancer in Barcelona. “The CALGB/SWOG 80405 trial was designed and formulated in 2005, and the rationale was simple: we had new drugs –bevacizumab and cetuximab– and the study was designed to determine if one was better than the other in first-line for patients with colon cancer,” said lead study author Alan P. Venook, distinguished Professor of Medical Oncology and Translational Research at the University of California, San Francisco, USA Continue reading

Phase III trial shows improved survival with TAS-102 in metastatic colorectal cancer refractory to standard therapies

Phase III trial shows improved survival with TAS-102 in metastatic colorectal cancer refractory to standard therapies

The new combination agent TAS-102 is able to improve overall survival compared to placebo in patients whose metastatic colorectal cancer is refractory to standard therapies, researchers said at the ESMO 16th World Congress on Gastrointestinal Cancer in Barcelona. “Around 50% of patients with colorectal cancer develop metastases but eventually many of them do not respond to standard therapies,” said Takayuki Yoshino of the National Cancer Centre Hospital East in Chiba, Japan, lead author of the phase III RECOURSE trial. Continue reading

Some aggressive cancers may respond to anti-inflammatory drugs

Some aggressive cancers may respond to anti-inflammatory drugs

New research raises the prospect that some cancer patients with aggressive tumors may benefit from a class of anti-inflammatory drugs used to treat rheumatoid arthritis. Studying triple-negative breast cancer, researchers at Washington University School of Medicine in St Continue reading

Some aggressive cancers may respond to anti-inflammatory drugs

Some aggressive cancers may respond to anti-inflammatory drugs

New research raises the prospect that some cancer patients with aggressive tumors may benefit from a class of anti-inflammatory drugs used to treat rheumatoid arthritis. Studying triple-negative breast cancer, researchers at Washington University School of Medicine in St. Louis found that some aggressive tumors rely on an antiviral pathway that appears to drive inflammation, widely recognized for roles in cancer, rheumatoid arthritis and other inflammatory diseases. Continue reading

One in 10 deaths among working-age adults in U.S. due to excessive drinking, report finds

One in 10 deaths among working-age adults in U.S. due to excessive drinking, report finds

Excessive alcohol use accounts for one in 10 deaths among working-age adults ages 20-64 years in the United States, according to a report from the Centers for Disease Control and Prevention published June 26 in Preventing Chronic Disease . Excessive alcohol use led to approximately 88,000 deaths per year from 2006 to 2010, and shortened the lives of those who died by about 30 years. Continue reading

One in 10 deaths among working-age adults in U.S. due to excessive drinking, report finds

One in 10 deaths among working-age adults in U.S. due to excessive drinking, report finds

Excessive alcohol use accounts for one in 10 deaths among working-age adults ages 20-64 years in the United States, according to a report from the Centers for Disease Control and Prevention published June 26 in Preventing Chronic Disease . Excessive alcohol use led to approximately 88,000 deaths per year from 2006 to 2010, and shortened the lives of those who died by about 30 years. These deaths were due to health effects from drinking too much over time, such as breast cancer, liver disease, and heart disease; and health effects from drinking too much in a short period of time, such as violence, alcohol poisoning, and motor vehicle crashes Continue reading

Early life stress can leave lasting impacts on the brain

Early life stress can leave lasting impacts on the brain

For children, stress can go a long way. Continue reading

Early life stress can leave lasting impacts on the brain

Early life stress can leave lasting impacts on the brain

For children, stress can go a long way. A little bit provides a platform for learning, adapting and coping. Continue reading

Homeless alcoholics typically began drinking as children

Homeless alcoholics typically began drinking as children

A phenomenological study offers detailed insights into homeless, alcohol-dependent patients often stigmatized by the public and policymakers as drains on the health care system, showing the constellation of reasons they are incapable of escaping social circumstances that perpetuate and exacerbate their problems The study, published online in Annals of Emergency Medicine , was conducted at Bellevue Hospital in New York City, which has a long history of service to the city’s indigent population. Continue reading

Homeless alcoholics typically began drinking as children

Homeless alcoholics typically began drinking as children

A phenomenological study offers detailed insights into homeless, alcohol-dependent patients often stigmatized by the public and policymakers as drains on the health care system, showing the constellation of reasons they are incapable of escaping social circumstances that perpetuate and exacerbate their problems The study, published online in Annals of Emergency Medicine , was conducted at Bellevue Hospital in New York City, which has a long history of service to the city’s indigent population. “One hundred percent of patients enrolled in the study began drinking alcohol as children, becoming alcohol-dependent shortly thereafter,” said study author Ryan McCormack, MD, of New York University School of Medicine in New York, N.Y. “For people who have homes and jobs, it is difficult to imagine the level of despair these people experience day in and day out, or the all-consuming focus on getting the next drink that overrides even the most basic human survival instinct Continue reading