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Yeast provides genetic clues on drug response

Yeast provides genetic clues on drug response

Why do people respond differently to the same drug? For the first time, researchers have untangled genetic and environmental factors related to drug reactions, bringing us a step closer to predicting how a drug will affect us. Researchers at the University of British Columbia exposed 6,000 strains of yeast to 3,000 drugs Continue reading

Yeast provides genetic clues on drug response

Yeast provides genetic clues on drug response

Why do people respond differently to the same drug? For the first time, researchers have untangled genetic and environmental factors related to drug reactions, bringing us a step closer to predicting how a drug will affect us Continue reading

Common sense health for young adult cancer survivors

Common sense health for young adult cancer survivors

Many factors influence the life expectancy of childhood cancer survivors: not getting enough exercise, being underweight, and being worried about their future health or their health insurance. Continue reading

Common sense health for young adult cancer survivors

Common sense health for young adult cancer survivors

Many factors influence the life expectancy of childhood cancer survivors: not getting enough exercise, being underweight, and being worried about their future health or their health insurance. These are the findings of research led by Cheryl Cox of the St. Continue reading

Enzyme ‘wrench’ could be key to stronger, more effective antibiotics

Enzyme ‘wrench’ could be key to stronger, more effective antibiotics

Builders and factory workers know that getting a job done right requires precision and specialized tools. The same is true when you’re building antibiotic compounds at the molecular level. New findings from North Carolina State University may turn an enzyme that acts as a specialized “wrench” in antibiotic assembly into a set of wrenches that will allow for greater customization. Continue reading

Mechanism that regulates lung function in disease Birt-Hogg-Dube syndrome found

Mechanism that regulates lung function in disease Birt-Hogg-Dube syndrome found

Researchers at Penn Medicine have discovered that the tumor suppressor gene folliculin (FLCN) is essential to normal lung function in patients with the rare disease Birt-Hogg-Dube (BHD) syndrome, a genetic disorder that affects the lungs, skin and kidneys. Continue reading

Transcription factors distinguishing glioblastoma stem cells identified

Transcription factors distinguishing glioblastoma stem cells identified

The activity of four transcription factors — proteins that regulate the expression of other genes — appears to distinguish the small proportion of glioblastoma cells responsible for the aggressiveness and treatment resistance of the deadly brain tumor. The findings by a team of Massachusetts General Hospital (MGH) investigators, which will be published in the April 24 issue of Cell and are receiving advance online release, support the importance of epigenetics — processes controlling whether or not genes are expressed — in cancer pathology and identify molecular circuits that may be targeted by new therapeutic approaches. Continue reading

Bad penny: Cancer’s thirst for copper can be targeted

Bad penny: Cancer’s thirst for copper can be targeted

Drugs used to block copper absorption for a rare genetic condition may find an additional use as a treatment for certain types of cancer, researchers at Duke Medicine report. The researchers found that cancers with a mutation in the BRAF gene require copper to promote tumor growth. These tumors include melanoma, the most dangerous form of skin cancer that kills an estimated 10,000 people in the United States a year, according to the National Cancer Institute. Continue reading

Cancer cells may respond to mechanical force

Cancer cells may respond to mechanical force

The push and pull of physical force can cause profound changes in the behavior of a cell. Two studies from researchers working at the UNC Lineberger Comprehensive Cancer Center reveal how cells respond to mechanical manipulation, a key factor in addressing the underlying causes of cancer and other diseases. Continue reading