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Moderate levels of ‘free radicals’ found beneficial to healing wounds

Moderate levels of ‘free radicals’ found beneficial to healing wounds

Long assumed to be destructive to tissues and cells, “free radicals” generated by the cell’s mitochondria — the energy producing structures in the cell — are actually beneficial to healing wounds. That’s the conclusion of biologists at UC San Diego who discovered that “reactive oxygen species” — chemically reactive molecules containing oxygen, such as peroxides, commonly referred to as free radicals — are necessary for the proper healing of skin wounds in the laboratory roundworm C. elegans. Continue reading

New cancer drug to begin trials in multiple myeloma patients

New cancer drug to begin trials in multiple myeloma patients

Scientists at Imperial College London have developed a new cancer drug which they plan to trial in multiple myeloma patients by the end of next year. In a paper published today in the journal Cancer Cell , the researchers report how the drug, known as DTP3, kills myeloma cells in laboratory tests in human cells and mice, without causing any toxic side effects, which is the main problem with most other cancer drugs. The new drug works by stopping a key process that allows cancer cells to multiply Continue reading

Bio-inspired ‘nano-cocoons’ offer targeted drug delivery against cancer cells

Bio-inspired ‘nano-cocoons’ offer targeted drug delivery against cancer cells

Biomedical engineering researchers have developed a drug delivery system consisting of nanoscale “cocoons” made of DNA that target cancer cells and trick the cells into absorbing the cocoon before unleashing anticancer drugs. The work was done by researchers at North Carolina State University and the University of North Carolina at Chapel Hill. “This drug delivery system is DNA-based, which means it is biocompatible and less toxic to patients than systems that use synthetic materials,” says Dr. Continue reading

Bio-inspired ‘nano-cocoons’ offer targeted drug delivery against cancer cells

Bio-inspired ‘nano-cocoons’ offer targeted drug delivery against cancer cells

Biomedical engineering researchers have developed a drug delivery system consisting of nanoscale “cocoons” made of DNA that target cancer cells and trick the cells into absorbing the cocoon before unleashing anticancer drugs. The work was done by researchers at North Carolina State University and the University of North Carolina at Chapel Hill. “This drug delivery system is DNA-based, which means it is biocompatible and less toxic to patients than systems that use synthetic materials,” says Dr. Continue reading

Pneumococcal vaccine reduces antibiotic-resistant infections in children by 62 percent

Pneumococcal vaccine reduces antibiotic-resistant infections in children by 62 percent

The pneumococcal vaccine recommended for young children not only prevents illness and death, but also has dramatically reduced severe antibiotic-resistant infections, suggests nationwide research being presented at IDWeek 2014™. Continue reading

Pneumococcal vaccine reduces antibiotic-resistant infections in children by 62 percent

Pneumococcal vaccine reduces antibiotic-resistant infections in children by 62 percent

The pneumococcal vaccine recommended for young children not only prevents illness and death, but also has dramatically reduced severe antibiotic-resistant infections, suggests nationwide research being presented at IDWeek 2014™. Pneumococcal infection — which can cause everything from ear infections to pneumonia and meningitis — is the most common vaccine-preventable bacterial cause of death Continue reading

Insisting only on randomised controlled trials for Ebola treatments unethical, impractical, say leading health experts

Insisting only on randomised controlled trials for Ebola treatments unethical, impractical, say leading health experts

Date: October 10, 2014 Source: The Lancet Summary: Leading health experts urge the deployment of alternative trial designs to fast-track the evaluation of new Ebola treatments. Senior health professionals and medical ethicists, from Africa, Europe, and USA, argue that although randomized controlled trials (RCTs) provide robust evidence in most circumstances, the lack of effective treatment options for Ebola, high mortality with the current standard of care, and the paucity of effective health care systems in the affected regions means that alternative trial designs need to be considered. Continue reading

Insisting only on randomised controlled trials for Ebola treatments unethical, impractical, say leading health experts

Insisting only on randomised controlled trials for Ebola treatments unethical, impractical, say leading health experts

Date: October 10, 2014 Source: The Lancet Summary: Leading health experts urge the deployment of alternative trial designs to fast-track the evaluation of new Ebola treatments. Senior health professionals and medical ethicists, from Africa, Europe, and USA, argue that although randomized controlled trials (RCTs) provide robust evidence in most circumstances, the lack of effective treatment options for Ebola, high mortality with the current standard of care, and the paucity of effective health care systems in the affected regions means that alternative trial designs need to be considered. Continue reading

Tumor registry data find acadiana colon cancer rates among America’s highest

Tumor registry data find acadiana colon cancer rates among America’s highest

A special study using data from LSU Health New Orleans School of Public Health’s Louisiana Tumor Registry has found that colorectal cancer incidence rates in the Louisiana Acadian parishes are among the highest in the United States. This study appears to be the first to identify a high rate of cancer in a large, regional, US founder population, raising the possibility of a genetic predisposition. Continue reading

Tumor registry data find acadiana colon cancer rates among America’s highest

Tumor registry data find acadiana colon cancer rates among America’s highest

A special study using data from LSU Health New Orleans School of Public Health’s Louisiana Tumor Registry has found that colorectal cancer incidence rates in the Louisiana Acadian parishes are among the highest in the United States. This study appears to be the first to identify a high rate of cancer in a large, regional, US founder population, raising the possibility of a genetic predisposition. Alternatively, an unidentified, robust environmental risk factor may be present. Continue reading