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Real-time tracking system developed to monitor dangerous bacteria inside body

Real-time tracking system developed to monitor dangerous bacteria inside body

Combining a PET scanner with a new chemical tracer that selectively tags specific types of bacteria, Johns Hopkins researchers working with mice report they have devised a way to detect and monitor in real time infections with a class of dangerous Gram-negative bacteria. These increasingly drug-resistant bacteria are responsible for a range of diseases, including fatal pneumonias and various bloodstream or solid-organ infections acquired in and outside the hospital. “What we have produced is essentially a system that localizes the epicenter of infection and provides real-time tracking of bacterial activity, giving us rapid feedback on how the bacteria respond to antibiotics,” says principal investigator Sanjay Jain, M.D., an infectious disease specialist at the Johns Hopkins Children’s Center and director of the Center for Inflammation Imaging and Research at Johns Hopkins Continue reading

Staph ‘gangs’ share nutrients during infection

Staph ‘gangs’ share nutrients during infection

Antibiotic-resistant bacteria can share resources to cause chronic infections, Vanderbilt investigators have discovered. Like the individual members of a gang who might be relatively harmless alone, they turn deadly when they get together with their “friends.” The findings, reported Oct. 8 in Cell Host & Microbe , shed light on a long-standing question in infectious diseases and may inform new treatment strategies, said Eric Skaar, Ph.D., MPH, Ernest W Continue reading

Defective gene renders diarrhea vaccine ineffective

Defective gene renders diarrhea vaccine ineffective

Acute diarrheal illnesses cause nearly one-fifth of all child deaths in developing countries. The most common cause is rotavirus. Continue reading

Oral capsule as effective as invasive procedures for delivery of fecal transplant

Oral capsule as effective as invasive procedures for delivery of fecal transplant

A noninvasive method of delivering a promising therapy for persistent Clostridium difficile ( C. difficile ) infection appears to be as effective as treatment via colonoscopy or through a nasogastric tube Continue reading

Pneumococcal vaccine reduces antibiotic-resistant infections in children by 62 percent

Pneumococcal vaccine reduces antibiotic-resistant infections in children by 62 percent

The pneumococcal vaccine recommended for young children not only prevents illness and death, but also has dramatically reduced severe antibiotic-resistant infections, suggests nationwide research being presented at IDWeek 2014™. Continue reading

Pneumococcal vaccine reduces antibiotic-resistant infections in children by 62 percent

Pneumococcal vaccine reduces antibiotic-resistant infections in children by 62 percent

The pneumococcal vaccine recommended for young children not only prevents illness and death, but also has dramatically reduced severe antibiotic-resistant infections, suggests nationwide research being presented at IDWeek 2014™. Pneumococcal infection — which can cause everything from ear infections to pneumonia and meningitis — is the most common vaccine-preventable bacterial cause of death Continue reading

College athletes in contact sports more likely to carry MRSA, study finds

College athletes in contact sports more likely to carry MRSA, study finds

Even if they don’t show signs of infection, college athletes who play football, soccer and other contact sports are more likely to carry the superbug methicillin-resistant Staphylococcus aureus (MRSA), suggests a study on MRSA and athletes, which is being presented at IDWeek 2014™. This puts them at higher risk for infection and increases the likelihood of spreading the bug, which can cause serious and even fatal infections. The study is the first to observe college athletes who are not part of a larger MRSA outbreak Continue reading

Effect of antibiotic susceptibility for patients with bloodstream infection

Effect of antibiotic susceptibility for patients with bloodstream infection

In an analysis of more than 8,000 episodes of Staphylococcus aureus bloodstream infections, there were no significant differences in the risk of death when comparing patients exhibiting less susceptibility to the antibiotic vancomycin to patients with more vancomycin susceptible strains of S. Continue reading

Investigation into GI scope-related infections changes national guidelines

Investigation into GI scope-related infections changes national guidelines

National guidelines for the cleaning of certain gastrointestinal (GI) scopes are likely to be updated due to findings from UPMC’s infection prevention team. Continue reading

Programs to improve hand hygiene reduced infections, increased compliance

Programs to improve hand hygiene reduced infections, increased compliance

UPMC Presbyterian Hospital’s infection prevention teams have improved hand washing and sanitizing compliance at the hospital to nearly 100 percent among clinical staff through accountability and educational measures. In a separate effort at UPMC Mercy Hospital, rates of a deadly infection were reduced by educating patients about hand hygiene. Continue reading