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Multitarget TB drug could treat other diseases, evade resistance

Multitarget TB drug could treat other diseases, evade resistance

A drug under clinical trials to treat tuberculosis could be the basis for a class of broad-spectrum drugs that act against various bacteria, fungal infections and parasites, yet evade resistance, according to a study by University of Illinois chemists and collaborators. Led by U. Continue reading

How the immune system protects children from malaria

How the immune system protects children from malaria

According to a study published today in PLOS Pathogens , children who live in regions of the world where malaria is common can mount an immune response to infection with malaria parasites that may enable them to avoid repeated bouts of high fever and illness and partially control the growth of malaria parasites in their bloodstream. The findings may help researchers develop future interventions that prevent or mitigate the disease caused by the malaria parasite. Continue reading

Novel stapled peptide nanoparticle combination prevents RSV infection, study finds

Novel stapled peptide nanoparticle combination prevents RSV infection, study finds

New therapies are needed to prevent and treat respiratory syncytial virus (RSV) — a potentially lethal respiratory infection that can severely affect infants, young children and the elderly. Despite a wide range of anti-RSV efforts, there are no vaccines or drugs on the market to effectively prevent or treat the infection. Now researchers at the Dana-Farber/Boston Children’s Cancer and Blood Disorders Center and Harvard Medical School in Boston, MA, and the James A. Continue reading

HIV and schistosomiasis coinfection in African children: More research needed

HIV and schistosomiasis coinfection in African children: More research needed

Researchers from LSTM have called for more research to be carried out into HIV and schistosomiasis coinfection in children in sub-Saharan Africa. In a paper in The Lancet Infectious Diseases LSTM’s Professor Russell Stothard, working with colleagues in the department of Parasitology and researchers from Cape Western Reserve University, in Cleveland Ohio, University of Cambridge and the Royal Veterinary College looked at previous research into the joint burden of HIV/AIDS and schistosomiasis of children, and found that while disease-specific control interventions are continuing, potential synergies in the control efforts for the two diseases have not been investigated. Continue reading

HIV-positive women respond well to HPV vaccine, study shows

HIV-positive women respond well to HPV vaccine, study shows

HIV-positive women respond well to a vaccine against the human papillomavirus (HPV), even when their immune system is struggling, according to newly published results of an international clinical trial. Continue reading

Using video surveillance to measure peoples’ hand washing habits

Using video surveillance to measure peoples’ hand washing habits

One of the best defenses against infectious disease is one of the most simple — hand washing. Still, despite years of global public awareness campaigns, hand washing rates remain low. Continue reading

Using video surveillance to measure peoples’ hand washing habits

Using video surveillance to measure peoples’ hand washing habits

One of the best defenses against infectious disease is one of the most simple — hand washing. Continue reading

Whooping cough bacterium evolving in Australia, research shows

Whooping cough bacterium evolving in Australia, research shows

The bacterium that causes whooping cough, Bordetella pertussis , has changed in Australia — most likely in response to the vaccine used to prevent the disease — with a possible reduced effectiveness of the vaccine as a result, a new study shows. A UNSW-led team of researchers analyzed strains of Bordetella pertussis from across Australia and found that many strains no longer produce a key surface protein called pertactin Continue reading

Whooping cough bacterium evolving in Australia, research shows

Whooping cough bacterium evolving in Australia, research shows

The bacterium that causes whooping cough, Bordetella pertussis , has changed in Australia — most likely in response to the vaccine used to prevent the disease — with a possible reduced effectiveness of the vaccine as a result, a new study shows. A UNSW-led team of researchers analyzed strains of Bordetella pertussis from across Australia and found that many strains no longer produce a key surface protein called pertactin Continue reading

New combination drug therapy proves very effective in hepatitis C treatments

New combination drug therapy proves very effective in hepatitis C treatments

Treatment options for the 170 million people worldwide with chronic Hepatitis C Virus (HCV) are evolving rapidly, although the available regimens often come with significant side effects. Two multi-center clinical trials led by Beth Israel Deaconess Medical Center show promise for a new option that could help lead to both an increase in patients cured with a much more simple and tolerable all oral therapy Continue reading