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Twenty-five percent of breast cancer survivors report financial decline due to treatment

Twenty-five percent of breast cancer survivors report financial decline due to treatment

Four years after being treated for breast cancer, a quarter of survivors say they are worse off financially, at least partly because of their treatment, according to a new study led by University of Michigan Comprehensive Cancer Center researchers. In addition, 12 percent reported that they still have medical debt from their treatment. Continue reading

Better predictor of prostate cancer survival proposed by research

Better predictor of prostate cancer survival proposed by research

New research by USC Norris Comprehensive Cancer Center scientists demonstrates that measuring circulating tumor cells (CTCs) — the cells that spread cancer through the body — may be a better predictor of patient survival than the prostate specific antigen (PSA). The research was published March 10, 2014 in the Journal of Clinical Oncology by a team led by Amir Goldkorn, M.D., assistant professor of medicine at USC Norris, part of Keck Medicine of USC. Goldkorn’s team discovered that elevated CTC counts after chemotherapy indicated as much as a five-fold higher risk of death, and for patients whose CTCs dropped by 50 percent or more, the risk of death was cut in half Continue reading

Characteristics of lung cancers arising in genetic mutation carriers

Characteristics of lung cancers arising in genetic mutation carriers

Two studies are providing new insight into germline epidermal growth factor receptor ( EGFR ) T790M mutation in familial non-small cell lung cancer (NSCLC). The findings suggest the need for tailored approaches for early detection and treatment, as well as for genetic testing to identify carriers. Continue reading

Surprising new way to kill cancer cells

Surprising new way to kill cancer cells

Northwestern Medicine scientists have demonstrated that cancer cells — and not normal cells — can be killed by eliminating either the FAS receptor, also known as CD95, or its binding component, CD95 ligand. “The discovery seems counterintuitive because CD95 has previously been defined as a tumor suppressor,” said lead investigator Marcus Peter, professor in medicine-hematology/Oncology at Northwestern University Feinberg School of Medicine. “But when we removed it from cancer cells, rather than proliferate, they died.” The findings were published March 20 in Cell Reports Continue reading

Increased risk of relapse omitting radiotherapy in early PET scan negative Hodgkin lymphoma

Increased risk of relapse omitting radiotherapy in early PET scan negative Hodgkin lymphoma

Interim analysis of the intergroup EORTC-LYSA-FIL 20051 H10 trial published in the Journal of Clinical Oncology i ndicates an increased risk of early relapse when omitting radiotherapy in early PET scan negative patients with stage I/II Hodgkin’s lymphoma. Early outcome, however, was excellent in both arms, and the final analysis should reveal whether these initial findings are maintained over time. Continue reading

Increased risk of relapse omitting radiotherapy in early PET scan negative Hodgkin lymphoma

Increased risk of relapse omitting radiotherapy in early PET scan negative Hodgkin lymphoma

Interim analysis of the intergroup EORTC-LYSA-FIL 20051 H10 trial published in the Journal of Clinical Oncology i ndicates an increased risk of early relapse when omitting radiotherapy in early PET scan negative patients with stage I/II Hodgkin’s lymphoma. Early outcome, however, was excellent in both arms, and the final analysis should reveal whether these initial findings are maintained over time. Continue reading

Health gap between adult survivors of childhood cancer, siblings widens with age

Health gap between adult survivors of childhood cancer, siblings widens with age

Adult survivors of childhood cancer face significant health problems as they age and are five times more likely than their siblings to develop new cancers, heart and other serious health conditions beyond the age of 35, according to the latest findings from the world’s largest study of childhood cancer survivors. St. Jude Children’s Research Hospital led the research, results of which appear in the March 17 issue of the Journal of Clinical Oncology Continue reading

Pathways that direct immune system to turn ‘on’ or ‘off’ found

Pathways that direct immune system to turn ‘on’ or ‘off’ found

A key discovery explaining how components of the immune system determine whether to activate or to suppress the immune system, made by Kelvin Lee, MD, Professor of Oncology and Co-Leader of the Tumor Immunology and Immunotherapy Program at Roswell Park Cancer Institute (RPCI), and colleagues led to published findings being selected as the “Paper of the Week” by the Journal of Biological Chemistry (JBC). Continue reading

New nanoparticle that only attacks cervical cancer cells

New nanoparticle that only attacks cervical cancer cells

One of the most promising technologies for the treatment of various cancers is nanotechnology, creating drugs that directly attack the cancer cells without damaging other tissues’ development. The Laboratory of Cellular Oncology at the Research Unit in Cell Differentiation and Cancer, of the Faculty of Higher Studies (FES) Zaragoza UNAM (National Autonomous University of Mexico) developed a therapy to attack cervical cancer tumors. Continue reading

Link between diabetes, pancreatic cancer found

Link between diabetes, pancreatic cancer found

Researchers from the University of Melbourne have shown that there is an association between pancreatic cancer and diabetes. In a new study published today in Annals of Surgical Oncology , clinicians worked with mathematicians to review data from 1973 to 2013 to conclude there was a time-dependent link between being diagnosed with diabetes and pancreatic cancer. A review of 88 international studies to date, is the largest analysis on the topic published. Continue reading