List/Grid

Oncology Subscribe to Oncology

Functional nerve cells from skin cells

Functional nerve cells from skin cells

A new method of generating mature nerve cells from skin cells could greatly enhance understanding of neurodegenerative diseases, and could accelerate the development of new drugs and stem cell-based regenerative medicine. The nerve cells generated by this new method show the same functional characteristics as the mature cells found in the body, making them much better models for the study of age-related diseases such as Parkinson’s and Alzheimer’s, and for the testing of new drugs. Eventually, the technique could also be used to generate mature nerve cells for transplantation into patients with a range of neurodegenerative diseases Continue reading

Should cardiac screening guidelines for survivors of childhood cancer be reviewed?

Should cardiac screening guidelines for survivors of childhood cancer be reviewed?

One of the first studies to analyze the effectiveness of screening survivors of childhood cancer for early signs of impending congestive heart failure (CHF) finds improved health outcomes but suggests that less frequent screening than currently recommended may yield similar clinical benefit. Continue reading

Cognitive behavioral or relaxation training helps women reduce distress during breast cancer treatment

Cognitive behavioral or relaxation training helps women reduce distress during breast cancer treatment

Can psychological intervention help women adapt to the stresses of breast cancer? It appears that a brief, five-week psychological intervention can have beneficial effects for women who are dealing with the stresses of breast cancer diagnosis and surgery. Continue reading

Glutamine ratio is key ovarian cancer indicator

Glutamine ratio is key ovarian cancer indicator

A Rice University-led analysis of the metabolic profiles of hundreds of ovarian tumors has revealed a new test to determine whether ovarian cancer cells have the potential to metastasize, or spread to other parts of the body. The study also suggests how ovarian cancer treatments can be tailored based on the metabolic profile of a particular tumor Continue reading

Pediatricians call for a Vitamin K tracking system for babies not getting shots

Pediatricians call for a Vitamin K tracking system for babies not getting shots

Doctors at Monroe Carell Jr. Children’s Hospital at Vanderbilt have seen a rise in late-onset vitamin K deficiency bleeding in young infants due to parents declining the shot at birth Continue reading

Hyperfractionated radiation therapy improves local-regional control for patients with head, neck cancer

Hyperfractionated radiation therapy improves local-regional control for patients with head, neck cancer

Patients with locally advanced squamous cell carcinoma of the head and neck treated with hyperfractionated radiation therapy (HFX) experienced improved local-regional control and, with patients censored at five years, improved overall survival with no increase in late toxicity, according to a study published in the May 1, 2014 edition of the International Journal of Radiation Oncology • Biology • Physics (Red Journal), the official scientific journal of the American Society for Radiation Oncology (ASTRO). This study, “Final Results of Local-Regional Control and Late Toxicity of RTOG 9003: A Randomized Trial of Altered Fractionation Radiation for Locally Advanced Head and Neck Cancer,” is a multi-institutional, randomized Phase III trial of fractionation in locally advanced head and neck cancer. The study, the largest fractionation study performed to date, evaluated patients who received standard fractionation (SFX) compared to those that received HFX, accelerated fractionation with a split (AFX-S) or accelerated fractionation-continuous (AFX-C). Continue reading

Breast cancer patients place huge emphasis on gene expression profiling test

Breast cancer patients place huge emphasis on gene expression profiling test

Gene expression profiling tests play a critical role when women with early-stage breast cancer decide whether to have chemotherapy, but many of them do not fully understand what some of the test results mean, new research suggests. Current guidelines for treating early-stage breast cancer — cancer that has not spread to nearby lymph nodes or other parts of the body — result in thousands of women receiving chemotherapy without benefitting from it. A gene expression profiling test can help differentiate women who might benefit from chemotherapy versus those that might not. Continue reading

Breast cancer patients place huge emphasis on gene expression profiling test

Breast cancer patients place huge emphasis on gene expression profiling test

Gene expression profiling tests play a critical role when women with early-stage breast cancer decide whether to have chemotherapy, but many of them do not fully understand what some of the test results mean, new research suggests. Current guidelines for treating early-stage breast cancer — cancer that has not spread to nearby lymph nodes or other parts of the body — result in thousands of women receiving chemotherapy without benefitting from it. A gene expression profiling test can help differentiate women who might benefit from chemotherapy versus those that might not. Continue reading

Mechanism of cancer caused by loss of BRCA1, BRCA2 gene function identified

Mechanism of cancer caused by loss of BRCA1, BRCA2 gene function identified

Inherited mutations in the BRCA1 or BRCA2 tumor suppressor genes are by far the most frequent contributors to hereditary cancer risk in the human population, often causing breast or ovarian cancer in young women of child-bearing age. Attempts to test the role that the BRCA genes play in regulating a repair process associated with genome duplication have proven frustratingly difficult in living mammalian cells. Now investigators at Beth Israel Deaconess Medical Center (BIDMC) report a new mechanism by which BRCA gene loss may accelerate cancer-promoting chromosome rearrangements Continue reading

Mechanism of cancer caused by loss of BRCA1, BRCA2 gene function identified

Mechanism of cancer caused by loss of BRCA1, BRCA2 gene function identified

Inherited mutations in the BRCA1 or BRCA2 tumor suppressor genes are by far the most frequent contributors to hereditary cancer risk in the human population, often causing breast or ovarian cancer in young women of child-bearing age. Attempts to test the role that the BRCA genes play in regulating a repair process associated with genome duplication have proven frustratingly difficult in living mammalian cells. Now investigators at Beth Israel Deaconess Medical Center (BIDMC) report a new mechanism by which BRCA gene loss may accelerate cancer-promoting chromosome rearrangements Continue reading