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Scientists report success growing cartilage to reconstruct nostrils and implanting tissue-engineered vaginal organs into humans

Scientists report success growing cartilage to reconstruct nostrils and implanting tissue-engineered vaginal organs into humans

Two new articles published in The Lancet report the first ever successful operations in humans to reconstruct the alar wings of the nose (nostrils) (Martin et al ), and to implant tissue-engineered vaginal organs in women with a rare syndrome that causes the vagina to be underdeveloped or absent (Atala et al ), in both cases using the patients’ own tissue. In one paper, led by Professor Ivan Martin from the University of Basel in Switzerland, scientists report having engineered a human cartilage graft from patients’ own nasal septum cartilage cells to successfully rebuild the nostrils (alar lobule) of five individuals whose noses were damaged by skin cancer Continue reading

Scientists report success growing cartilage to reconstruct nostrils and implanting tissue-engineered vaginal organs into humans

Scientists report success growing cartilage to reconstruct nostrils and implanting tissue-engineered vaginal organs into humans

Two new articles published in The Lancet report the first ever successful operations in humans to reconstruct the alar wings of the nose (nostrils) (Martin et al ), and to implant tissue-engineered vaginal organs in women with a rare syndrome that causes the vagina to be underdeveloped or absent (Atala et al ), in both cases using the patients’ own tissue. In one paper, led by Professor Ivan Martin from the University of Basel in Switzerland, scientists report having engineered a human cartilage graft from patients’ own nasal septum cartilage cells to successfully rebuild the nostrils (alar lobule) of five individuals whose noses were damaged by skin cancer Continue reading

New general concept for treatment of cancer

New general concept for treatment of cancer

A team of researchers from five Swedish universities, led by Karolinska Institutet and the Science for Life Laboratory, have identified a new way of treating cancer. The concept is presented in the journal Nature and is based on inhibiting a specific enzyme called MTH1, which cancer cells, unlike normal cells, require for survival. Without this enzyme, oxidized nucleotides are incorporated into DNA, resulting in lethal DNA double-strand breaks in cancer cells. Continue reading

Medication does not reduce risk of recurrent cardiac events among patients with diabetes

Medication does not reduce risk of recurrent cardiac events among patients with diabetes

Use of the drug aleglitazar, which has shown the ability to lower glucose levels and have favorable effects on cholesterol, did not reduce the risk of cardiovascular death, heart attack or stroke among patients with type 2 diabetes and recent heart attack or unstable angina, according to a JAMA study released online to coincide with presentation at the 2014 American College of Cardiology Scientific Sessions. Cardiovascular disease remains the dominant cause of death among patients with type 2 diabetes. No drug therapy specifically directed against diabetes nor strategy for tight glucose control has been shown to unequivocally reduce the rate of cardiovascular complications in this population, according to background information in the article. Continue reading

Analysis supports use of risk equations to guide statin therapy

Analysis supports use of risk equations to guide statin therapy

In an analysis of almost 11,000 patients, an assessment of equations that help guide whether a patient should begin taking a statin (cholesterol lowering medication) found that observed and predicted 5-year atherosclerotic cardiovascular disease risks were similar, suggesting that these equations are helpful for clinical decision making, according to a JAMA study released online to coincide with presentation at the 2014 American College of Cardiology Scientific Sessions. The American College of Cardiology (ACC) and the American Heart Association (AHA) recently published the 2013 Guideline on the Assessment of Cardiovascular Risk. As part of this guideline, a group of experts developed the Pooled Cohort risk equations, which were designed to estimate 10-year risk for nonfatal myocardial infarction (MI; heart attack), coronary heart disease (CHD) death, and nonfatal or fatal stroke, according to background information in the article Continue reading

Analysis supports use of risk equations to guide statin therapy

Analysis supports use of risk equations to guide statin therapy

In an analysis of almost 11,000 patients, an assessment of equations that help guide whether a patient should begin taking a statin (cholesterol lowering medication) found that observed and predicted 5-year atherosclerotic cardiovascular disease risks were similar, suggesting that these equations are helpful for clinical decision making, according to a JAMA study released online to coincide with presentation at the 2014 American College of Cardiology Scientific Sessions. Continue reading

Girls protected from autism, study suggests

Girls protected from autism, study suggests

It takes more mutations to trigger autism in women than in men, which may explain why men are four times more likely to have the disorder, according to a study published 26 February in the A merican Journal of Human Genetics . The study found that women with autism or developmental delay tend to have more large disruptions in their genomes than do men with the disorder. Inherited mutations are also more likely to be passed down from unaffected mothers than from fathers. Continue reading

Girls protected from autism, study suggests

Girls protected from autism, study suggests

It takes more mutations to trigger autism in women than in men, which may explain why men are four times more likely to have the disorder, according to a study published 26 February in the A merican Journal of Human Genetics . The study found that women with autism or developmental delay tend to have more large disruptions in their genomes than do men with the disorder. Inherited mutations are also more likely to be passed down from unaffected mothers than from fathers. Continue reading

When big isn’t better: How the flu bug bit Google

When big isn’t better: How the flu bug bit Google

Numbers and data can be critical tools in bringing complex issues into crisp focus. Continue reading

3D printing used for stem cells

3D printing used for stem cells

4 February 2013 Last updated at 20:05 ET A 3D printing technique that produces clusters of stem cells could speed up progress towards creating artificial organs, Edinburgh scientists have claimed. In the more immediate future it could be used to generate biopsy-like tissue samples for drug testing. The technique relies on an adjustable “microvalve” to build up layers of human embryonic stem cells (hESCs). Continue reading