List/Grid

Tag Archives: biology

Novel stapled peptide nanoparticle combination prevents RSV infection, study finds

Novel stapled peptide nanoparticle combination prevents RSV infection, study finds

New therapies are needed to prevent and treat respiratory syncytial virus (RSV) — a potentially lethal respiratory infection that can severely affect infants, young children and the elderly. Despite a wide range of anti-RSV efforts, there are no vaccines or drugs on the market to effectively prevent or treat the infection. Now researchers at the Dana-Farber/Boston Children’s Cancer and Blood Disorders Center and Harvard Medical School in Boston, MA, and the James A. Continue reading

Tracking flu levels with Wikipedia

Tracking flu levels with Wikipedia

Can monitoring Wikipedia hits show how many people have the flu? Researchers at Boston Children’s Hospital, USA, have developed a method of estimating levels of influenza-like illness in the American population by analysing Internet traffic on specific flu-related Wikipedia articles. David McIver and John Brownstein’s model, publishing in PLOS Computational Biology on April 17th, estimates flu levels in the American population up to two weeks sooner than data from the Centers for Disease Control and Prevention becomes available, and accurately estimates the week of peak influenza activity 17% more often than Google Flu Trends data Continue reading

Fighting malaria drug resistance: Scientists find new way

Fighting malaria drug resistance: Scientists find new way

An anti-malarial treatment that lost its status as the leading weapon against the deadly disease could be given a new lease of life, with new research indicating it simply needs to be administered differently. The findings could revive the use of the cheap anti-malarial drug chloroquine in treating and preventing the mosquito-bourne disease, which claims the lives of more than half a million people each year around the world. The parasite that causes malaria has developed resistance to chloroquine, but research carried out at the Australian National University (ANU) and Germany’s University of Heidelberg has shown that the parasite protein that causes resistance has an Achilles’ heel Continue reading

Eavesdropping on brain cell chatter

Eavesdropping on brain cell chatter

Everything we do — all of our movements, thoughts and feelings — are the result of neurons talking with one another, and recent studies have suggested that some of the conversations might not be all that private. Brain cells known as astrocytes may be listening in on, or even participating in, some of those discussions. Continue reading

Cancer drugs block dementia-linked brain inflammation, study finds

Cancer drugs block dementia-linked brain inflammation, study finds

A class of drugs developed to treat immune-related conditions and cancer — including one currently in clinical trials for glioblastoma and other tumors — eliminates neural inflammation associated with dementia-linked diseases and brain injuries, according to UC Irvine researchers. In their study, assistant professor of neurobiology & behavior Kim Green and colleagues discovered that the drugs, which can be delivered orally, eradicated microglia, the primary immune cells of the brain. These cells exacerbate many neural diseases, including Alzheimer’s and Parkinson’s, as well as brain injury Continue reading

Cancer drugs block dementia-linked brain inflammation, study finds

Cancer drugs block dementia-linked brain inflammation, study finds

A class of drugs developed to treat immune-related conditions and cancer — including one currently in clinical trials for glioblastoma and other tumors — eliminates neural inflammation associated with dementia-linked diseases and brain injuries, according to UC Irvine researchers. In their study, assistant professor of neurobiology & behavior Kim Green and colleagues discovered that the drugs, which can be delivered orally, eradicated microglia, the primary immune cells of the brain. These cells exacerbate many neural diseases, including Alzheimer’s and Parkinson’s, as well as brain injury. Continue reading

Synapses: stability in transformation

Synapses: stability in transformation

Synapses are the points of contact at which information is transmitted between neurons. Without them, we would not be able to form thoughts or remember things. Continue reading

Fighting neuroblastomas by blocking DNA replication, repair

Fighting neuroblastomas by blocking DNA replication, repair

Neuroblastoma is one of the deadliest childhood cancers, accounting for 15 percent of pediatric cancer deaths. For patients with high-risk neuroblastomas, the five-year survival rate is 40 to 50 percent even with the most rigorous treatments available today. But those odds may improve soon, thanks to a new compound developed by City of Hope scientists Continue reading

Fighting neuroblastomas by blocking DNA replication, repair

Fighting neuroblastomas by blocking DNA replication, repair

Neuroblastoma is one of the deadliest childhood cancers, accounting for 15 percent of pediatric cancer deaths. For patients with high-risk neuroblastomas, the five-year survival rate is 40 to 50 percent even with the most rigorous treatments available today Continue reading

Potent, puzzling and (now less) toxic: Team discovers how antifungal drug works

Potent, puzzling and (now less) toxic: Team discovers how antifungal drug works

Scientists have solved a decades-old medical mystery — and in the process have found a potentially less toxic way to fight invasive fungal infections, which kill about 1.5 million people a year. The researchers say they now understand the mechanism of action of amphotericin, an antifungal drug that has been in use for more than 50 years — even though it is nearly as toxic to human cells as it is to the microbes it attacks. Continue reading