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Tag Archives: California

Finding keys to glioblastoma therapeutic resistance

Finding keys to glioblastoma therapeutic resistance

Researchers at the University of California, San Diego School of Medicine have found one of the keys to why certain glioblastomas — the primary form of a deadly brain cancer — are resistant to drug therapy. The answer lies not in the DNA sequence of the tumor, but in its epigenetic signature Continue reading

Newborn screening expansion offers early diagnosis and treatment to infants with SCID

Newborn screening expansion offers early diagnosis and treatment to infants with SCID

Using population-based screening outcomes of approximately 3 million infants, a team of scientists across 14 states, including four researchers at the University of Massachusetts Medical School, have shown that newborn screening for severe combined immunodeficiency (SCID) can be successfully implemented across public health newborn screening programs. Data from 11 newborn screening programs published in the Aug. 20 issue of the Journal of the American Medical Association ( JAMA ) showed the rate of SCID in newborns is higher than previously thought and believed to be 1 in 58,000 Continue reading

New mouse model points to therapy for liver disease

New mouse model points to therapy for liver disease

Non-alcoholic fatty liver disease (NAFLD) is a common affliction, affecting almost 30 percent of Americans, with a significant number suffering from its most severe form, called non-alcoholic steatohepatitis or NASH, which can lead to cirrhosis and liver cancer. In recent years, NASH has become the leading cause of liver transplantation Continue reading

Lead released from African cookware contaminates food

Lead released from African cookware contaminates food

Lead levels in foods prepared in aluminum pots from Cameroon exceed U.S. Continue reading

Dramatic growth of grafted stem cells in rat spinal cord

Dramatic growth of grafted stem cells in rat spinal cord

Building upon previous research, scientists at the University of California, San Diego School of Medicine and Veteran’s Affairs San Diego Healthcare System report that neurons derived from human induced pluripotent stem cells (iPSC) and grafted into rats after a spinal cord injury produced cells with tens of thousands of axons extending virtually the entire length of the animals’ central nervous system. Writing in the August 7 early online edition of Neuron , lead scientist Paul Lu, PhD, of the UC San Diego Department of Neurosciences and colleagues said the human iPSC-derived axons extended through the white matter of the injury sites, frequently penetrating adjacent gray matter to form synapses with rat neurons. Continue reading

Low uptake of colorectal cancer screening by African Americans shown in study

Low uptake of colorectal cancer screening by African Americans shown in study

According to researchers in California, African Americans’ participation in colorectal cancer screening is low and the use of colonoscopy infrequent despite similar access to care across races in a Veterans Affairs healthcare system. The researchers also found that having established primary care at the time of screening eligibility significantly increased screening uptake. Continue reading

Seamless gene correction of beta-thalassemia mutations in patient-specific cells

Seamless gene correction of beta-thalassemia mutations in patient-specific cells

A major hurdle in gene therapy is the efficient integration of a corrected gene into a patient’s genome without mutating off-target sites. In a paper published today in Genome Research , scientists have used CRISPR/Cas genome editing technology to seamlessly and efficiently correct disease-causing mutations in cells from patients with β-thalassemia Continue reading

Missing sleep may hurt your memory

Missing sleep may hurt your memory

Lack of sleep, already considered a public health epidemic, can also lead to errors in memory, finds a new study by researchers at Michigan State University and the University of California, Irvine. The study, published online in the journal Psychological Science , found participants deprived of a night’s sleep were more likely to flub the details of a simulated burglary they were shown in a series of images Continue reading

Experts urge new discipline combining benefits of neuroscience, psychology treatments

Experts urge new discipline combining benefits of neuroscience, psychology treatments

When a patient talks with a psychological therapist, what changes occur in the patient’s brain that relieve mental disorders? UCLA psychology professor Michelle Craske says the honest answer is that we don’t know. Continue reading

Personalized approach enhances communication skills in children with autism

Personalized approach enhances communication skills in children with autism

A UCLA-led study has found that the communication skills of minimally verbal children with autism can be greatly improved through personalized interventions that are combined with the use of computer tablets. Continue reading