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Tag Archives: Cell

A matter of life and death: Cell death proteins key to fighting disease

A matter of life and death: Cell death proteins key to fighting disease

Melbourne researchers have uncovered key steps involved in programmed cell death, offering new targets for the treatment of diseases including lupus, cancers and neurodegenerative diseases. The research teams from the Walter and Eliza Hall Institute worked together to discover the three-dimensional structure of a key cell death protein called Bak and reveal the first steps in how it causes cell death Continue reading

Ciliopathies: New insights into development

Ciliopathies: New insights into development

To date, it is still not clear how proteins regulate planar cell polarity (PCP) or the positioning of the basal body (BB) and cilia. Continue reading

Moderate levels of ‘free radicals’ found beneficial to healing wounds

Moderate levels of ‘free radicals’ found beneficial to healing wounds

Long assumed to be destructive to tissues and cells, “free radicals” generated by the cell’s mitochondria — the energy producing structures in the cell — are actually beneficial to healing wounds. That’s the conclusion of biologists at UC San Diego who discovered that “reactive oxygen species” — chemically reactive molecules containing oxygen, such as peroxides, commonly referred to as free radicals — are necessary for the proper healing of skin wounds in the laboratory roundworm C. elegans. Continue reading

Moderate levels of ‘free radicals’ found beneficial to healing wounds

Moderate levels of ‘free radicals’ found beneficial to healing wounds

Long assumed to be destructive to tissues and cells, “free radicals” generated by the cell’s mitochondria — the energy producing structures in the cell — are actually beneficial to healing wounds. That’s the conclusion of biologists at UC San Diego who discovered that “reactive oxygen species” — chemically reactive molecules containing oxygen, such as peroxides, commonly referred to as free radicals — are necessary for the proper healing of skin wounds in the laboratory roundworm C. elegans. Continue reading

Bio-inspired ‘nano-cocoons’ offer targeted drug delivery against cancer cells

Bio-inspired ‘nano-cocoons’ offer targeted drug delivery against cancer cells

Biomedical engineering researchers have developed a drug delivery system consisting of nanoscale “cocoons” made of DNA that target cancer cells and trick the cells into absorbing the cocoon before unleashing anticancer drugs. The work was done by researchers at North Carolina State University and the University of North Carolina at Chapel Hill. “This drug delivery system is DNA-based, which means it is biocompatible and less toxic to patients than systems that use synthetic materials,” says Dr. Continue reading

Bio-inspired ‘nano-cocoons’ offer targeted drug delivery against cancer cells

Bio-inspired ‘nano-cocoons’ offer targeted drug delivery against cancer cells

Biomedical engineering researchers have developed a drug delivery system consisting of nanoscale “cocoons” made of DNA that target cancer cells and trick the cells into absorbing the cocoon before unleashing anticancer drugs. The work was done by researchers at North Carolina State University and the University of North Carolina at Chapel Hill. “This drug delivery system is DNA-based, which means it is biocompatible and less toxic to patients than systems that use synthetic materials,” says Dr. Continue reading

A diet for the cell: Keeping DNA fit with fewer calories

A diet for the cell: Keeping DNA fit with fewer calories

Cells are generally able to repair spontaneous damage that arises in their genetic material. Unfortunately, the DNA repair process is not perfect and sometimes, damaged DNA gets passed on to newly made cells Continue reading

Small molecule ‘jams the switch’ to prevent inflammatory cell death

Small molecule ‘jams the switch’ to prevent inflammatory cell death

Walter and Eliza Hall Institute scientists have discovered a small molecule that blocks a form of cell death that triggers inflammation, opening the door for potential new treatments for inflammatory disease such as rheumatoid arthritis, Crohn’s disease and psoriasis. The researchers made the discovery while investigating how a protein called MLKL kills cells in a process known as necroptosis. Their findings were published today in the journal Proceedings of the National Academy of Sciences . Continue reading

Tumors might grow faster at night

Tumors might grow faster at night

They emerge at night, while we sleep unaware, growing and spreading out as quickly as they can. And they are deadly. Continue reading

Chemists recruit anthrax to deliver cancer drugs

Chemists recruit anthrax to deliver cancer drugs

Bacillus anthracis bacteria have very efficient machinery for injecting toxic proteins into cells, leading to the potentially deadly infection known as anthrax. Continue reading