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Work with small peptide chains may revolutionize study of enzymes, diseases

Work with small peptide chains may revolutionize study of enzymes, diseases

Chemists in The College of Arts and Sciences have, for the first time, created enzyme-like activity using peptides that are only seven amino acids long. Continue reading

Flipping the switch on scleroderma

Flipping the switch on scleroderma

Scleroderma is a rare and often fatal disease, causing the thickening of tissue, that currently lacks a cure and any effective treatments. A group of researchers, including a Michigan State University professor, is looking to change that. “Our findings provide a new approach to developing better treatment options where few have existed,” said Richard Neubig, chairperson of the Department of Pharmacology and Toxicology in MSU’s College of Osteopathic Medicine Continue reading

Researchers identify how zinc regulates key enzyme involved in cell death

Researchers identify how zinc regulates key enzyme involved in cell death

The molecular details of how zinc, an essential trace element of human metabolism, interacts with the enzyme caspase-3, which is central to apoptosis or cell death, have been elucidated in a new study led by researchers at Virginia Commonwealth University. Continue reading

Eating seven or more portions of fruit and vegetables a day reduces your risk of death by 42 percent

Eating seven or more portions of fruit and vegetables a day reduces your risk of death by 42 percent

Eating seven or more portions of fruit and vegetables a day reduces your risk of death at any point in time by 42% compared to eating less than one portion, reports a new UCL study. Researchers used the Health Survey for England to study the eating habits of 65,226 people representative of the English population between 2001 and 2013, and found that the more fruit and vegetables they ate, the less likely they were to die at any age. Continue reading

New human trial shows stem cells are effective for failing hearts: Bone marrow-derived stem cells injected directly into heart muscle

New human trial shows stem cells are effective for failing hearts: Bone marrow-derived stem cells injected directly into heart muscle

Patients with severe ischemic heart disease and heart failure can benefit from a new treatment in which stem cells found in bone marrow are injected directly into the heart muscle, according to research presented at the American College of Cardiology’s 63rd Annual Scientific Session. “Our results show that this stem cell treatment is safe and it improves heart function when compared to placebo,” said Anders Bruun Mathiasen, M.D., research fellow in the Cardiac Catherization Lab at Rigshospitalet University Hospital Copenhagen, and lead investigator of the study. “This represents an exciting development that has the potential to benefit many people who suffer from this common and deadly disease.” Ischemic heart disease, also known as coronary artery disease, is the number one cause of death for both men and women in the United States Continue reading

New human trial shows stem cells are effective for failing hearts: Bone marrow-derived stem cells injected directly into heart muscle

New human trial shows stem cells are effective for failing hearts: Bone marrow-derived stem cells injected directly into heart muscle

Patients with severe ischemic heart disease and heart failure can benefit from a new treatment in which stem cells found in bone marrow are injected directly into the heart muscle, according to research presented at the American College of Cardiology’s 63rd Annual Scientific Session. “Our results show that this stem cell treatment is safe and it improves heart function when compared to placebo,” said Anders Bruun Mathiasen, M.D., research fellow in the Cardiac Catherization Lab at Rigshospitalet University Hospital Copenhagen, and lead investigator of the study Continue reading

Real-world heart procedure results consistent with scientific research

Real-world heart procedure results consistent with scientific research

The first one-year outcomes data of transcatheter heart valve replacement (TAVR) in nearly all U.S. Continue reading

Real-world heart procedure results consistent with scientific research

Real-world heart procedure results consistent with scientific research

The first one-year outcomes data of transcatheter heart valve replacement (TAVR) in nearly all U.S. patients undergoing this procedure shows that real-world outcomes are comparable to or slightly better than those found in clinical trials, according to registry data presented at the American College of Cardiology’s 63rd Annual Scientific Session. However, specific baseline characteristics of patients undergoing TAVR are associated with differing degrees of death and survival and may be important considerations for patient counseling and shared decision making about the procedure, according to the authors Continue reading

Blood test helps predict heart attack risk for patients with chest pain

Blood test helps predict heart attack risk for patients with chest pain

Patients presenting to the emergency department with an undetectable level of the blood biomarker high-sensitivity cardiac troponin T, and whose ECGs show no sign of restricted blood flow, have a minimal risk of heart attack within 30 days, according to research presented at the American College of Cardiology’s 63rd Annual Scientific Session. In a study of all patients (14,636 in total) reporting to a Swedish emergency department with chest pain over a two-year period from 2010 to 2012, researchers examined patients’ blood levels of high-sensitivity cardiac troponin T, a marker that indicates damage to the heart Continue reading

Cardiac resynchronization improves survival in heart failure patients

Cardiac resynchronization improves survival in heart failure patients

Patients in mild heart failure who receive a specialized pacemaker known as cardiac resynchronization therapy with a defibrillator (CRT-D) may live longer than those implanted with a traditional implantable cardioverter defibrillator (ICD), according to research presented at the American College of Cardiology’s 63rd Annual Scientific Session. In the first study to look at CRT-D in mildly symptomatic patients, researchers found that patients with left bundle branch block implanted with a CRT-D had a 41 percent reduced risk of death compared to patients who had a conventional ICD Continue reading