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Scientists report success growing cartilage to reconstruct nostrils and implanting tissue-engineered vaginal organs into humans

Scientists report success growing cartilage to reconstruct nostrils and implanting tissue-engineered vaginal organs into humans

Two new articles published in The Lancet report the first ever successful operations in humans to reconstruct the alar wings of the nose (nostrils) (Martin et al ), and to implant tissue-engineered vaginal organs in women with a rare syndrome that causes the vagina to be underdeveloped or absent (Atala et al ), in both cases using the patients’ own tissue. In one paper, led by Professor Ivan Martin from the University of Basel in Switzerland, scientists report having engineered a human cartilage graft from patients’ own nasal septum cartilage cells to successfully rebuild the nostrils (alar lobule) of five individuals whose noses were damaged by skin cancer Continue reading

DNA modifications measured in blood signal related changes in the brain

DNA modifications measured in blood signal related changes in the brain

Johns Hopkins researchers say they have confirmed suspicions that DNA modifications found in the blood of mice exposed to high levels of stress hormone — and showing signs of anxiety — are directly related to changes found in their brain tissues. The proof-of-concept study, reported online ahead of print in the June issue of Psychoneuroendocrinology , offers what the research team calls the first evidence that epigenetic changes that alter the way genes function without changing their underlying DNA sequence — and are detectable in blood — mirror alterations in brain tissue linked to underlying psychiatric diseases. The new study reports only on so-called epigenetic changes to a single stress response gene called FKBP5, which has been implicated in depression, bipolar disorder and post-traumatic stress disorder Continue reading

Fathers can lower their children’s risk of going hungry by staying involved

Fathers can lower their children’s risk of going hungry by staying involved

Fathers who don’t live with their children can actually lower their son’s or daughter’s risk of not having enough food by just maintaining involvement in the child’s life. And if the father provides support beyond money, such as gifts, groceries and other offerings, the child’s risk of food insecurity may be further reduced. Continue reading

Hope for children with previously incurable brain cancer

Hope for children with previously incurable brain cancer

Imagine the anguish of a parent whose child is diagnosed with an incurable form of childhood brain cancer. Surgery is not an option, current chemotherapy is ineffective and focal radiation only provides temporary relief. Remarkably, researchers from the Department of Laboratory Medicine and Pathobiology (LMP) have defined potential treatment targets for this relatively common cancer — providing hope for future patients Continue reading

Hope for children with previously incurable brain cancer

Hope for children with previously incurable brain cancer

Imagine the anguish of a parent whose child is diagnosed with an incurable form of childhood brain cancer. Continue reading

Risk of dengue fever epidemic in Europe

Risk of dengue fever epidemic in Europe

The risk of dengue fever beginning to spread in Europe is imminent. According to researchers from Umeå University, this is no longer just an issue for the scientific community but also for politicians and policy makers, who need to be prepared and develop preventive measures. Continue reading

Low-dose aspirin won’t prevent pregnancy loss, study shows

Low-dose aspirin won’t prevent pregnancy loss, study shows

The Effects of Aspirin in Gestation and Reproduction (EAGeR) medical trial has found that, in general, low-dose aspirin is not beneficial for future pregnancy outcomes in women with prior pregnancy loss. Continue reading

Flipping the switch on scleroderma

Flipping the switch on scleroderma

Scleroderma is a rare and often fatal disease, causing the thickening of tissue, that currently lacks a cure and any effective treatments. A group of researchers, including a Michigan State University professor, is looking to change that. “Our findings provide a new approach to developing better treatment options where few have existed,” said Richard Neubig, chairperson of the Department of Pharmacology and Toxicology in MSU’s College of Osteopathic Medicine Continue reading

Pocket-size ultrasonic nebulizer employing a novel nozzle improves inhalers

Pocket-size ultrasonic nebulizer employing a novel nozzle improves inhalers

Inhalation is an increasingly important route for non-invasive drug delivery for both systemic and local applications. Control of particle size and output plays a critical role in the efficient and effective delivery of oft en expensive medications to the lung Continue reading

Brawn matters: Stronger adolescents, teens have less risk of diabetes, heart disease

Brawn matters: Stronger adolescents, teens have less risk of diabetes, heart disease

Adolescents with stronger muscles have a lower risk of heart disease and diabetes, according to a new study that examined the influence of muscle strength in sixth grade boys and girls. Continue reading