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Tag Archives: Development

Tsetse fly genome reveals weaknesses: International 10-year project unravels biology of disease-causing fly

Tsetse fly genome reveals weaknesses: International 10-year project unravels biology of disease-causing fly

Mining the genome of the disease-transmitting tsetse fly, researchers have revealed the genetic adaptions that allow it to have such unique biology and transmit disease to both humans and animals. The tsetse fly spreads the parasitic diseases human African trypanosomiasis, known as sleeping sickness, and Nagana that infect humans and animals respectively. Throughout sub-Saharan Africa, 70 million people are currently at risk of deadly infection Continue reading

Tsetse fly genome reveals weaknesses: International 10-year project unravels biology of disease-causing fly

Tsetse fly genome reveals weaknesses: International 10-year project unravels biology of disease-causing fly

Mining the genome of the disease-transmitting tsetse fly, researchers have revealed the genetic adaptions that allow it to have such unique biology and transmit disease to both humans and animals. The tsetse fly spreads the parasitic diseases human African trypanosomiasis, known as sleeping sickness, and Nagana that infect humans and animals respectively. Throughout sub-Saharan Africa, 70 million people are currently at risk of deadly infection Continue reading

Scientists build new ‘off switch’ to shut down neural activity

Scientists build new ‘off switch’ to shut down neural activity

Nearly a decade ago, the era of optogenetics was ushered in with the development of channelrhodopsins, light-activated ion channels that can, with the flick of a switch, instantaneously turn on neurons in which they are genetically expressed. What has lagged behind, however, is the ability to use light to inactivate neurons with an equal level of reliability and efficiency. Now, Howard Hughes Medical Institute (HHMI) scientists have used an analysis of channelrhodopsin’s molecular structure to guide a series of genetic mutations to the ion channel that grant the power to silence neurons with an unprecedented level of control Continue reading

Scientists build new ‘off switch’ to shut down neural activity

Scientists build new ‘off switch’ to shut down neural activity

Nearly a decade ago, the era of optogenetics was ushered in with the development of channelrhodopsins, light-activated ion channels that can, with the flick of a switch, instantaneously turn on neurons in which they are genetically expressed. What has lagged behind, however, is the ability to use light to inactivate neurons with an equal level of reliability and efficiency. Now, Howard Hughes Medical Institute (HHMI) scientists have used an analysis of channelrhodopsin’s molecular structure to guide a series of genetic mutations to the ion channel that grant the power to silence neurons with an unprecedented level of control Continue reading

Novel compound halts cocaine addiction, relapse behaviors

Novel compound halts cocaine addiction, relapse behaviors

A novel compound that targets an important brain receptor has a dramatic effect against a host of cocaine addiction behaviors, including relapse behavior, a University at Buffalo animal study has found. Continue reading

Neuroimaging Technique: Live from inside the cell in real-time

Neuroimaging Technique: Live from inside the cell in real-time

A novel imaging technique provides insights into the role of redox signaling and reactive oxygen species in living neurons, in real time. Continue reading

Novel function of protein linked to Alzheimer’s disease discovered

Novel function of protein linked to Alzheimer’s disease discovered

A research team led by the National Neuroscience Institute (NNI) has uncovered a novel function of the Amyloid Precursor Protein (APP), one of the main pathogenic culprits of Alzheimer’s disease. This discovery may help researchers understand how the protein goes awry in the brains of Alzheimer’s disease patients, and potentially paves the way for the development of innovative therapeutics to improve the brain function of dementia patients. The findings were published in the scientific research journal Nature Communications last month Continue reading

Immune cells to be tested on the International Space Station

Immune cells to be tested on the International Space Station

The human body is fine-tuned to Earth’s gravity. A team headed by Professor Oliver Ullrich from the University of Zurich’s Institute of Anatomy is now conducting an experiment on the International Space Station (ISS) to study whether this also applies to human cells. On the evening of April 18, the transporter spaceship Dragon lifted off from the Cape Canaveral launch center in Florida with a cargo of UZH immune cells on board. Continue reading

Proteins conspire to make breast cancer cells resistant to drug treatment

Proteins conspire to make breast cancer cells resistant to drug treatment

Scientists at Sanford-Burnham Medical Research Institute (Sanford-Burnham) provide compelling and conclusive evidence that antiestrogen resistance in breast cancer cells requires the interaction between proteins called BCAR1 and BCAR3. In the study, published in the Journal of Biological Chemistry , the researchers also identified a signaling pathway that is crucial for drug resistance mediated by this protein complex Continue reading

Proteins conspire to make breast cancer cells resistant to drug treatment

Proteins conspire to make breast cancer cells resistant to drug treatment

Scientists at Sanford-Burnham Medical Research Institute (Sanford-Burnham) provide compelling and conclusive evidence that antiestrogen resistance in breast cancer cells requires the interaction between proteins called BCAR1 and BCAR3. In the study, published in the Journal of Biological Chemistry , the researchers also identified a signaling pathway that is crucial for drug resistance mediated by this protein complex Continue reading