List/Grid

Tag Archives: Diseases

Surprising diversity of antibody family provides clues for HIV vaccine design

Surprising diversity of antibody family provides clues for HIV vaccine design

Scientists at The Scripps Research Institute (TSRI) have described how a single family of antibodies that broadly neutralizes different strains of HIV has evolved remarkably diverse structures to attack a vulnerable site on the virus. The findings provide clues for the design of a future HIV vaccine. “In a sense, this antibody family takes more than one shot on goal in order to hit divergent forms of HIV,” said Ian A. Continue reading

Discovery may lead to better treatments for autoimmune diseases, bone loss

Discovery may lead to better treatments for autoimmune diseases, bone loss

Scientists have developed an approach to creating treatments for osteoporosis and autoimmune diseases that may avoid the risk of infection and cancer posed by some current medications. Researchers at Washington University School of Medicine in St. Louis redesigned a molecule that controls immune cell activity, changing the molecule’s target and altering the effects of the signal it sends. Continue reading

Discovery may lead to better treatments for autoimmune diseases, bone loss

Discovery may lead to better treatments for autoimmune diseases, bone loss

Scientists have developed an approach to creating treatments for osteoporosis and autoimmune diseases that may avoid the risk of infection and cancer posed by some current medications. Researchers at Washington University School of Medicine in St. Louis redesigned a molecule that controls immune cell activity, changing the molecule’s target and altering the effects of the signal it sends Continue reading

Chemists recruit anthrax to deliver cancer drugs

Chemists recruit anthrax to deliver cancer drugs

Bacillus anthracis bacteria have very efficient machinery for injecting toxic proteins into cells, leading to the potentially deadly infection known as anthrax. Continue reading

Chemists recruit anthrax to deliver cancer drugs

Chemists recruit anthrax to deliver cancer drugs

Bacillus anthracis bacteria have very efficient machinery for injecting toxic proteins into cells, leading to the potentially deadly infection known as anthrax. A team of MIT researchers has now hijacked that delivery system for a different purpose: administering cancer drugs. “Anthrax toxin is a professional at delivering large enzymes into cells,” says Bradley Pentelute, the Pfizer-Laubauch Career Development Assistant Professor of Chemistry at MIT. Continue reading

Premature deaths could be reduced by 40% over next 20 years, researchers say

Premature deaths could be reduced by 40% over next 20 years, researchers say

New research published today in The Lancet suggests that, with sustained international efforts, the number of premature deaths could be reduced by 40% over the next two decades (2010-2030), halving under-50 mortality and preventing a third of the deaths at ages 50-69 years. The findings reveal that, between 2000 and 2010, child deaths fell by one-third worldwide, helped by the fourth Millennium Development Goal (MDG) to reduce child deaths by two-thirds; and premature deaths among adults fell by one-sixth, helped by MDG 5 to reduce maternal mortality and MDG 6 to fight AIDS, malaria and other diseases. Continue reading

Biologists delay the aging process by ‘remote control’

Biologists delay the aging process by ‘remote control’

UCLA biologists have identified a gene that can slow the aging process throughout the entire body when activated remotely in key organ systems. Working with fruit flies, the life scientists activated a gene called AMPK that is a key energy sensor in cells; it gets activated when cellular energy levels are low Continue reading

Researchers discover key to making new muscles

Researchers discover key to making new muscles

Researchers at Sanford-Burnham Medical Research Institute (Sanford-Burnham) have developed a novel technique to promote tissue repair in damaged muscles. Continue reading

Dynamic duo takes out cellular trash: Research finds how dead cells are removed from body

Dynamic duo takes out cellular trash: Research finds how dead cells are removed from body

In most of the tissues of the body, specialized immune cells are entrusted with the task of engulfing the billions of dead cells that are generated every day. When these garbage disposals don’t do their job, dead cells and their waste products rapidly pile up, destroying healthy tissue and leading to autoimmune diseases such as lupus and rheumatoid arthritis. Continue reading

New enzyme targets for selective cancer therapies

New enzyme targets for selective cancer therapies

Thanks to important discoveries in basic and clinical research and technological advances, the fight against cancer has mobilized into a complex offensive spanning multiple fronts. Work happening in a University of Alberta chemistry lab could help find new and more selective therapies for cancer. Researchers have developed a compound that targets a specific enzyme overexpressed in certain cancers — and they have tested its activity in cells from brain tumours Continue reading