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Tag Archives: dna

Deadly human pathogen Cryptococcus fully sequenced

Deadly human pathogen Cryptococcus fully sequenced

Within each strand of DNA lies the blueprint for building an organism, along with the keys to its evolution and survival. These genetic instructions can give valuable insight into why pathogens like Cryptococcus neoformans — a fungus responsible for a million cases of pneumonia and meningitis every year — are so malleable and dangerous Continue reading

Fighting neuroblastomas by blocking DNA replication, repair

Fighting neuroblastomas by blocking DNA replication, repair

Neuroblastoma is one of the deadliest childhood cancers, accounting for 15 percent of pediatric cancer deaths. For patients with high-risk neuroblastomas, the five-year survival rate is 40 to 50 percent even with the most rigorous treatments available today Continue reading

Fighting neuroblastomas by blocking DNA replication, repair

Fighting neuroblastomas by blocking DNA replication, repair

Neuroblastoma is one of the deadliest childhood cancers, accounting for 15 percent of pediatric cancer deaths. For patients with high-risk neuroblastomas, the five-year survival rate is 40 to 50 percent even with the most rigorous treatments available today. But those odds may improve soon, thanks to a new compound developed by City of Hope scientists Continue reading

Experimental blood test spots recurrent breast cancers, monitors response to treatment

Experimental blood test spots recurrent breast cancers, monitors response to treatment

Johns Hopkins Kimmel Cancer Center investigators report they have designed a blood test that accurately detects the presence of advanced breast cancer and also holds promise for precisely monitoring response to cancer treatment. Continue reading

Finding the switch: Researchers create roadmap for gene expression

Finding the switch: Researchers create roadmap for gene expression

In a new study, researchers from North Carolina State University, UNC-Chapel Hill and other institutions have taken the first steps toward creating a roadmap that may help scientists narrow down the genetic cause of numerous diseases. Their work also sheds new light on how heredity and environment can affect gene expression Continue reading

Hereditary trauma: Inheritance of traumas and how they may be mediated

Hereditary trauma: Inheritance of traumas and how they may be mediated

Extreme and traumatic events can change a person — and often, years later, even affect their children. Continue reading

Hereditary trauma: Inheritance of traumas and how they may be mediated

Hereditary trauma: Inheritance of traumas and how they may be mediated

Extreme and traumatic events can change a person — and often, years later, even affect their children. Researchers of the University of Zurich and ETH Zurich have now unmasked a piece in the puzzle of how the inheritance of traumas may be mediated. The phenomenon has long been known in psychology: traumatic experiences can induce behavioural disorders that are passed down from one generation to the next Continue reading

Tumor-suppressor connects with histone protein to hinder gene expression

Tumor-suppressor connects with histone protein to hinder gene expression

A tumor-suppressing protein acts as a dimmer switch to dial down gene expression. It does this by reading a chemical message attached to another protein that’s tightly intertwined with DNA, a team led by scientists at The University of Texas MD Anderson Cancer Center reported at the AACR Annual Meeting 2014. The findings, also published in the journal Nature on April 10, provide evidence in support of the “histone code” hypothesis Continue reading

Tumor-suppressor connects with histone protein to hinder gene expression

Tumor-suppressor connects with histone protein to hinder gene expression

A tumor-suppressing protein acts as a dimmer switch to dial down gene expression. It does this by reading a chemical message attached to another protein that’s tightly intertwined with DNA, a team led by scientists at The University of Texas MD Anderson Cancer Center reported at the AACR Annual Meeting 2014. The findings, also published in the journal Nature on April 10, provide evidence in support of the “histone code” hypothesis. Continue reading