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Tag Archives: dna

Immunogenic mutations in tumor genomes correlate with increased patient survival

Immunogenic mutations in tumor genomes correlate with increased patient survival

Developing immunotherapies for cancer is challenging because of significant variability among tumors and diversity in human immune types. In a study published online today in Genome Research , researchers examined the largest collection of tumor samples to date to predict patient-specific tumor mutations that may activate the patient’s immune system, paving the way for more successful, personalized cancer immunotherapy Continue reading

New genome-editing platform significantly increases accuracy of CRISPR-based systems

New genome-editing platform significantly increases accuracy of CRISPR-based systems

A next-generation genome editing system developed by Massachusetts General Hospital (MGH) investigators substantially decreases the risk of producing unwanted, off-target gene mutations. In a paper receiving online publication in Nature Biotechnology , the researchers report a new CRISPR-based RNA-guided nuclease technology that uses two guide RNAs, significantly reducing the chance of cutting through DNA strands at mismatched sites. “This system combines the ease of use of the widely adopted CRISPR/Cas system with a dimerization-dependent nuclease activity that confers higher specificity of action,” says J. Continue reading

New genome-editing platform significantly increases accuracy of CRISPR-based systems

New genome-editing platform significantly increases accuracy of CRISPR-based systems

A next-generation genome editing system developed by Massachusetts General Hospital (MGH) investigators substantially decreases the risk of producing unwanted, off-target gene mutations. In a paper receiving online publication in Nature Biotechnology , the researchers report a new CRISPR-based RNA-guided nuclease technology that uses two guide RNAs, significantly reducing the chance of cutting through DNA strands at mismatched sites. “This system combines the ease of use of the widely adopted CRISPR/Cas system with a dimerization-dependent nuclease activity that confers higher specificity of action,” says J. Continue reading

Genome regions once mislabeled ‘junk’ linked to heart failure

Genome regions once mislabeled ‘junk’ linked to heart failure

Large sections of the genome that were once referred to as “junk” DNA have been linked to human heart failure, according to research from Washington University School of Medicine in St. Louis. So-called junk DNA was long thought to have no important role in heredity or disease because it doesn’t code for proteins Continue reading

Genome regions once mislabeled ‘junk’ linked to heart failure

Genome regions once mislabeled ‘junk’ linked to heart failure

Large sections of the genome that were once referred to as “junk” DNA have been linked to human heart failure, according to research from Washington University School of Medicine in St. Louis. Continue reading

Civil war inside our cells: Scientists show how our bodies fight off ‘jumping genes’

Civil war inside our cells: Scientists show how our bodies fight off ‘jumping genes’

There’s a civil war going on inside every one of the 37 trillion cells in your body. Now, University of Michigan scientists have uncovered how your cells keep this war from causing too much collateral damage. Continue reading

Low-dose natural antimicrobial exacerbates chronic lung infection in cystic fibrosis

Low-dose natural antimicrobial exacerbates chronic lung infection in cystic fibrosis

Respiratory failure caused by chronic lung infection with Pseudomonas aeruginosa bacteria is a common cause of death in patients with cystic fibrosis (CF), a genetic disease that is common in individuals of European descent. A study published on April 24th in PLOS Pathogens demonstrates that an antimicrobial peptide produced by human immune cells can promote mutations in the bacterium that make it more lethal. Continue reading

You may have billions and billions of good reasons for being unfit

You may have billions and billions of good reasons for being unfit

Although our chromosomes are relatively stable within our lifetimes, the genetic material found in our mitochondria is highly variable across individuals and may impact upon human health, say researchers at the University of Montreal and its affiliated CHU Sainte-Justine Hospital. Genomes are changing, not just from generation to generation, but even and in fact within our individual cells Continue reading

You may have billions and billions of good reasons for being unfit

You may have billions and billions of good reasons for being unfit

Although our chromosomes are relatively stable within our lifetimes, the genetic material found in our mitochondria is highly variable across individuals and may impact upon human health, say researchers at the University of Montreal and its affiliated CHU Sainte-Justine Hospital. Genomes are changing, not just from generation to generation, but even and in fact within our individual cells Continue reading

Male or female? First sex-determining genes appeared in mammals some 180 million years ago

Male or female? First sex-determining genes appeared in mammals some 180 million years ago

Man or woman? Male or female? In humans and other mammals, the difference between sexes depends on one single element of the genome: the Y chromosome Continue reading