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Tag Archives: dna

New technology offers insight into cholesterol

New technology offers insight into cholesterol

With new advanced techniques developed by the Copenhagen Center for Glycomics at the University of Copenhagen it is possible to study cells in greater detail than ever before. The findings have just been published in the Journal of Biological Chemistry and may, in the long term, improve the treatment of high cholesterol. Researchers from the Copenhagen Center for Glycomics at the University of Copenhagen have studied an important receptor protein called LDLR using new, groundbreaking techniques Continue reading

New insights into survival, transmission strategy of malaria parasites

New insights into survival, transmission strategy of malaria parasites

HP1 proteins are found in most eukaryotic organisms and are important regulators of gene silencing. Continue reading

Our ancestor’s ‘leaky’ membrane answers big questions in biology

Our ancestor’s ‘leaky’ membrane answers big questions in biology

All life on Earth came from one common ancestor — a single-celled organism — but what it looked like, how it lived and how it evolved into today’s modern cells is a four billion year old mystery being solved by researchers at UCL using mathematical modelling. Findings published in PLOS Biology suggest for the first time that life’s Last Universal Common Ancestor (LUCA) had a ‘leaky’ membrane, which helps scientists answer two of biology’s biggest questions: 1. Continue reading

Native bacteria block Wolbachia from being passed to mosquito progeny

Native bacteria block Wolbachia from being passed to mosquito progeny

Native bacteria living inside mosquitoes prevent the insects from passing Wolbachia bacteria — which can make the mosquitoes resistant to the malaria parasite — to their offspring, according to a team of researchers. The team found that Asaia , a type of bacteria that occurs naturally in Anopheles mosquitoes, blocks invasion of Wolbachia into the mosquitoes’ germlines — the cells that are passed on through successive generations of an organism — thus stopping the insects from transmitting Wolbachia to their offspring. ” Wolbachia infects up to 70 percent of all known insect species, but is notably absent from some groups, including the Anopheles mosquitoes that transmit malaria,” said Jason Rasgon, associate professor of entomology, Penn State. Continue reading

Preemies’ gut bacteria may depend more on gestational age than environment

Preemies’ gut bacteria may depend more on gestational age than environment

Scientists believe babies are born with digestive systems containing few or no bacteria. Their guts then quickly become colonized by microbes — good and bad — as they nurse or take bottles, receive medication and even as they are passed from one adoring relative to another. However, in infants born prematurely, researchers at Washington University School of Medicine in St. Continue reading

Editing HPV’s genes to kill cervical cancer cells

Editing HPV’s genes to kill cervical cancer cells

Researchers have hijacked a defense system normally used by bacteria to fend off viral infections and redirected it against the human papillomavirus (HPV), the virus that causes cervical, head and neck, and other cancers. Using the genome editing tool known as CRISPR, the Duke University researchers were able to selectively destroy two viral genes responsible for the growth and survival of cervical carcinoma cells, causing the cancer cells to self-destruct. The findings, appearing online August 7 in the Journal of Virology , give credence to an approach only recently attempted in mammalian cells, and could pave the way toward antiviral strategies targeted against other DNA-based viruses like hepatitis B and herpes simplex. Continue reading

Editing HPV’s genes to kill cervical cancer cells

Editing HPV’s genes to kill cervical cancer cells

Researchers have hijacked a defense system normally used by bacteria to fend off viral infections and redirected it against the human papillomavirus (HPV), the virus that causes cervical, head and neck, and other cancers. Using the genome editing tool known as CRISPR, the Duke University researchers were able to selectively destroy two viral genes responsible for the growth and survival of cervical carcinoma cells, causing the cancer cells to self-destruct. The findings, appearing online August 7 in the Journal of Virology , give credence to an approach only recently attempted in mammalian cells, and could pave the way toward antiviral strategies targeted against other DNA-based viruses like hepatitis B and herpes simplex Continue reading

Gut microbes browse along gene buffet

Gut microbes browse along gene buffet

In the moist, dark microbial rainforest of the intestine, hundreds of species of microorganisms interact with each other and with the cells of the host animal to get the resources they need to survive and thrive. Though there’s a lot of competition in this vibrant ecosystem, collaboration is valued too. A new study on the crosstalk between microbes and cells lining the gut of mice shows just how cooperative this environment can be Continue reading

Key piece to cancer cell survival puzzle found

Key piece to cancer cell survival puzzle found

An international team led by Eric A. Continue reading

Powerful new system for classifying tumors revealed

Powerful new system for classifying tumors revealed

Cancers are classified primarily on the basis of where in the body the disease originates, as in lung cancer or breast cancer. According to a new study, however, one in ten cancer patients would be classified differently using a new classification system based on molecular subtypes instead of the current tissue-of-origin system. Continue reading