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Tag Archives: Drug

Perampanel for epilepsy: Still no proof of added benefit

Perampanel for epilepsy: Still no proof of added benefit

The drug perampanel (trade name Fycompa) has been approved since July 2012 as adjunctive (“add-on”) therapy for adults and children aged 12 years and older with epileptic fits (seizures). In a new early benefit assessment according to the Act on the Reform of the Market for Medicinal Products (AMNOG), the German Institute for Quality and Efficiency in Health Care (IQWiG) examined whether perampanel offers an added benefit over the appropriate comparator therapy. However, such an added benefit cannot be derived from the new dossier either, as the drug manufacturer did not submit any relevant data for this comparison Continue reading

New culprit identified in metabolic syndrome

New culprit identified in metabolic syndrome

A new study suggests uric acid may play a role in causing metabolic syndrome, a cluster of risk factors that increases the risk of heart disease and type 2 diabetes. Uric acid is a normal waste product removed from the body by the kidneys and intestines and released in urine and stool. Continue reading

Trapped: Cell-invading piece of virus captured in lab by scientists

Trapped: Cell-invading piece of virus captured in lab by scientists

In recent research published in the Journal of Biological Chemistry , Saint Louis University investigators report catching integrase, the part of retroviruses like HIV that is responsible for insertion of the viral DNA into human cell DNA, in the presence of a drug designed to thwart it. This achievement sets the stage to use x-ray crystallography to develop complete images of HIV that include integrase, which in turn will help scientists develop new treatments for the illness. Duane Grandgenett, Ph.D., professor at SLU’s Institute of Molecular Virology and senior author of the study, discovered integrase in 1978, little knowing the piece of virus would provide the basis for an entire class of drugs that now treats HIV. Continue reading

Drug’s effect on Alzheimer’s may depend on severity of disease

Drug’s effect on Alzheimer’s may depend on severity of disease

A cancer drug that has shown promise against Alzheimer’s disease (AD) in mice and has begun early clinical trials has yielded perplexing results in a novel mouse model of AD that mimics the genetics and pathology of the human disease more closely than any other animal model. The drug, bexarotene, was found to reduce levels of the neurotoxic protein amyloid-beta in experimental mice with late-stage Alzheimer’s but to increase levels during early stages of disease. The finding, by researchers at the University of Illinois at Chicago College of Medicine, was reported July 16 at the Alzheimer’s Association International Conference in Copenhagen by Mary Jo LaDu, who in 2012 developed a transgenic mouse that is now regarded as the best animal model of the human disease. Continue reading

New assay to spot fake malaria drugs could save thousands of lives

New assay to spot fake malaria drugs could save thousands of lives

Chemists and students in science and engineering at Oregon State University have created a new type of chemical test, or assay, that’s inexpensive, simple, and can tell whether or not one of the primary drugs being used to treat malaria is genuine — an enormous and deadly problem in the developing world. The World Health Organization has estimated that about 200,000 lives a year may be lost due to the use of counterfeit anti-malarial drugs Continue reading

New combination drug controls tumor growth, metastasis in mice

New combination drug controls tumor growth, metastasis in mice

Researchers at UC Davis, University of Massachusetts and Harvard Medical School have created a combination drug that controls both tumor growth and metastasis. By combining a COX-2 inhibitor, similar to Celebrex, and an epoxide hydrolase (sEH) inhibitor, the drug controls angiogenesis (blood vessel formation), limiting a tumor’s ability to grow and spread. Continue reading

Nanoparticles used to enhance chemotherapy

Nanoparticles used to enhance chemotherapy

University of Georgia researchers have developed a new formulation of cisplatin, a common chemotherapy drug, that significantly increases the drug’s ability to target and destroy cancerous cells. Continue reading

Common heart drug’s link to diabetes uncovered by researchers

Common heart drug’s link to diabetes uncovered by researchers

McMaster University researchers may have found a novel way to suppress the devastating side effect of statins, one of the worlds’ most widely used drugs to lower cholesterol and prevent heart disease. The research team — led by Jonathan Schertzer, assistant professor of Biochemistry and Biomedical Sciences and Canadian Diabetes Association Scholar — discovered one of the pathways that link statins to diabetes. Their findings could lead to the next generation of statins by informing potential combination therapies while taking the drug Continue reading

Understanding active pharmaceutical ingredients

Understanding active pharmaceutical ingredients

Active pharmaceutical ingredient (API), is the term used to refer to the biologically active component of a drug product (e.g. tablet, capsule). Drug products are usually composed of several components Continue reading

Thalidomide victims in new legal bid

Thalidomide victims in new legal bid

unable to retrieve full-text contentUK Thalidomide victims launch legal action against the drug’s manufacturer and distributor 50 years after it was prescribed to their mothers. Continue reading