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Tag Archives: Drug

Potent, puzzling and (now less) toxic: Team discovers how antifungal drug works

Potent, puzzling and (now less) toxic: Team discovers how antifungal drug works

Scientists have solved a decades-old medical mystery — and in the process have found a potentially less toxic way to fight invasive fungal infections, which kill about 1.5 million people a year. The researchers say they now understand the mechanism of action of amphotericin, an antifungal drug that has been in use for more than 50 years — even though it is nearly as toxic to human cells as it is to the microbes it attacks. Continue reading

Potent, puzzling and (now less) toxic: Team discovers how antifungal drug works

Potent, puzzling and (now less) toxic: Team discovers how antifungal drug works

Scientists have solved a decades-old medical mystery — and in the process have found a potentially less toxic way to fight invasive fungal infections, which kill about 1.5 million people a year. The researchers say they now understand the mechanism of action of amphotericin, an antifungal drug that has been in use for more than 50 years — even though it is nearly as toxic to human cells as it is to the microbes it attacks. Continue reading

New drug, molecular insight into triple negative breast cancers

New drug, molecular insight into triple negative breast cancers

Most breast cancers are treated by blocking their addictions, for example depriving estrogen-fueled tumors of estrogen. Continue reading

New drug, molecular insight into triple negative breast cancers

New drug, molecular insight into triple negative breast cancers

Most breast cancers are treated by blocking their addictions, for example depriving estrogen-fueled tumors of estrogen. But what about breast cancers without these hormonal addictions Continue reading

Blocking DNA repair mechanisms could improve radiation therapy for deadly brain cancer

Blocking DNA repair mechanisms could improve radiation therapy for deadly brain cancer

UT Southwestern Medical Center researchers have demonstrated in both cancer cell lines and in mice that blocking critical DNA repair mechanisms could improve the effectiveness of radiation therapy for highly fatal brain tumors called glioblastomas. Radiation therapy causes double-strand breaks in DNA that must be repaired for tumors to keep growing Continue reading

Rilpivirine combination product in pretreated HIV-1 patients: Added benefit not proven

Rilpivirine combination product in pretreated HIV-1 patients: Added benefit not proven

The German Institute for Quality and Efficiency in Health Care (IQWiG) reassessed the antiviral drug combination rilpivirine/emtricitabine/tenofovir. Continue reading

Rilpivirine combination product in pretreated HIV-1 patients: Added benefit not proven

Rilpivirine combination product in pretreated HIV-1 patients: Added benefit not proven

The German Institute for Quality and Efficiency in Health Care (IQWiG) reassessed the antiviral drug combination rilpivirine/emtricitabine/tenofovir. In early 2012, the combination was approved for the treatment of adults infected with human immunodeficiency virus type 1 (HIV-1) who have not received previous antiretroviral treatment. Continue reading

Patient stem cells help identify common problem in ALS

Patient stem cells help identify common problem in ALS

Harvard stem cell scientists have discovered that a recently approved medication for epilepsy may possibly be a meaningful treatment for amyotrophic lateral sclerosis (ALS) — Lou Gehrig’s disease, a uniformly fatal neurodegenerative disorder. The researchers are now collaborating with Massachusetts General Hospital to design an initial clinical trial testing the safety of the treatment in ALS patients. The investigators all caution that a great deal needs to be done to assure the safety and efficacy of the treatment in ALS patients, before physicians should start offering it Continue reading

Children exposed to methamphetamine before birth have increased cognitive problems

Children exposed to methamphetamine before birth have increased cognitive problems

In the only long-term, National Institutes of Health-funded study of prenatal methamphetamine exposure and child outcome, researchers found youngsters exposed to the potent illegal drug before birth had increased cognitive problems at age 7.5 years, highlighting the need for early intervention to improve academic outcomes and reduce the potential for negative behaviors, according to the study published online by The Journal of Pediatrics . The researchers studied 151 children exposed to methamphetamine before birth and 147 who were not exposed to the drug Continue reading

Advance toward developing an oral pain reliever derived from debilitating snail venom

Advance toward developing an oral pain reliever derived from debilitating snail venom

Scientists have reported they have created at least five new experimental substances — based on a tiny protein found in cone snail venom — that could someday lead to the development of safe and effective oral medications for treatment of chronic nerve pain. Continue reading