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Tag Archives: Drugs

Causes of death shifting in people with HIV

Causes of death shifting in people with HIV

HIV-positive adults in high income countries face a substantially reduced risk of death from AIDS-related causes, cardiovascular disease, and liver disease compared with a decade ago, according to a large international study published in The Lancet. The study which involved nearly 50,000 HIV-positive adults receiving care and antiretroviral therapy (ART) at more than 200 clinics across Europe, USA, and Australia found that overall death rates have almost halved since 1999, while deaths due to AIDS-related causes and cardiovascular disease have declined by around 65% and liver-related deaths by more than 50%. Although deaths from most causes declined over the study period, there was no reduction in death rates from non-AIDS cancers which remained stable over time (1.6 deaths per 1000 years 1999-2000 to 2.1 in 2009-2011) Continue reading

One injection stops diabetes in its tracks: Treatment reverses symptoms of type 2 diabetes in mice without side effects

One injection stops diabetes in its tracks: Treatment reverses symptoms of type 2 diabetes in mice without side effects

In mice with diet-induced diabetes — the equivalent of type 2 diabetes in humans — a single injection of the protein FGF1 is enough to restore blood sugar levels to a healthy range for more than two days. The discovery by Salk scientists, published today in the journal Nature , could lead to a new generation of safer, more effective diabetes drugs Continue reading

One injection stops diabetes in its tracks: Treatment reverses symptoms of type 2 diabetes in mice without side effects

One injection stops diabetes in its tracks: Treatment reverses symptoms of type 2 diabetes in mice without side effects

In mice with diet-induced diabetes — the equivalent of type 2 diabetes in humans — a single injection of the protein FGF1 is enough to restore blood sugar levels to a healthy range for more than two days. The discovery by Salk scientists, published today in the journal Nature , could lead to a new generation of safer, more effective diabetes drugs Continue reading

Marijuana dependence alters the brain’s response to drug paraphernalia

Marijuana dependence alters the brain’s response to drug paraphernalia

New research from The University of Texas at Dallas demonstrates that drug paraphernalia triggers the reward areas of the brain differently in dependent and non-dependent marijuana users. The study, published July 1 in Drug and Alcohol Dependence , demonstrated that different areas of the brain activated when dependent and non-dependent users were exposed to drug-related cues. The 2012 National Survey on Drug Use and Health shows marijuana is the most widely used illicit drug in the United States Continue reading

New compound blocks ‘gatekeeper’ enzyme to kill malaria

New compound blocks ‘gatekeeper’ enzyme to kill malaria

Melbourne researchers are homing in on a new target for malaria treatment, after developing a compound that blocks the action of a key ‘gatekeeper’ enzyme essential for malaria parasite survival. The compound, called WEHI-916, is the first step toward a new class of antimalarial drugs that could cure and prevent malaria infections caused by all species of the parasite, including those resistant to existing drugs Continue reading

Prior drug use is greatest predictor of ecstasy use among U.S. high school seniors

Prior drug use is greatest predictor of ecstasy use among U.S. high school seniors

Ecstasy, also known by its chemical abbreviation MDMA, is an illicit drug that is commonly taken at nightclubs and dance parties. Ecstasy’s street names include: “Molly” (U.S.), “Mandy” (U.K.), “E,” and “X.” Although not limited to nightlife scenes, ecstasy is popular at dance parties, as it tends to enhance the party experience (e.g., perceptions of lights and music, nightlife socialization). A study just published in the journal Substance Use & Misuse by researchers affiliated with New York University’s Center for Drug Use and HIV Research (CDUHR), examined a national sample of high school seniors to determine who is currently at high risk for ecstasy use. Continue reading

How genetic mutation causes early brain damage

How genetic mutation causes early brain damage

Scientists from the Florida campus of The Scripps Research Institute (TSRI) have shed light on how a specific kind of genetic mutation can cause damage during early brain development that results in lifelong learning and behavioral disabilities. The work suggests new possibilities for therapeutic intervention. Continue reading

How genetic mutation causes early brain damage

How genetic mutation causes early brain damage

Scientists from the Florida campus of The Scripps Research Institute (TSRI) have shed light on how a specific kind of genetic mutation can cause damage during early brain development that results in lifelong learning and behavioral disabilities. The work suggests new possibilities for therapeutic intervention. Continue reading

E-cigarettes far less harmful than cigarettes, says researcher

E-cigarettes far less harmful than cigarettes, says researcher

A London School of Economics researcher examining the public and private dangers of drugs argues against demonizing e-cigarettes in a presentation being given at a conference of the Institute for Operations Research and the Management Sciences (INFORMS). He also calls on public officials to recognize that alcohol causes greater harm than other recreational drugs and more public attention should be paid to controlling its harmful effects Continue reading

Severe scoliosis linked to rare mutations

Severe scoliosis linked to rare mutations

Children with rare mutations in two genes are about four times more likely to develop severe scoliosis than their peers with normal versions of the genes, scientists have found. The research at Washington University School of Medicine in St. Continue reading