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Tag Archives: Drugs

Trastuzumab should remain as standard of care for HER2-positive breast cancer, trial suggests

Trastuzumab should remain as standard of care for HER2-positive breast cancer, trial suggests

Analysis of more than 8,000 women who participated in the world’s largest study of two treatments for HER2-positive breast cancer reinforces other findings from the clinical trial showing that trastuzumab (Herceptin) should remain the standard of care for this cancer, says a Mayo Clinic researcher. This study, being presented at the European Society for Medical Oncology (ESMO) 2014 Congress in Madrid, reveals that when used as a single HER2-targeted therapy in addition to standard chemotherapy, trastuzumab offers a better outcome than does lapatinib (Tykerb), says Edith A. Continue reading

New hepatitis c medication in children to be studied

New hepatitis c medication in children to be studied

After the success of a new drug treatment in adults with hepatitis C infection, a Saint Louis University pediatric researcher is testing the safety and efficacy of the medications in children. Part of a multi-center clinical study, SLU is the only center in the region that will examine a combination of two drugs — Sofosbuvir and Ribavirin — in children between ages 3 and 17 Continue reading

New statin guidelines an improvement, study shows

New statin guidelines an improvement, study shows

New national guidelines can improve the way statin drugs are prescribed to patients at risk for cardiovascular disease, a Yale University study has found. The research, published Aug. 25 in the Journal of the American College of Cardiology , also showed the new guidelines produce only a modest increase in the number of patients being given the drugs Continue reading

New shock-and-kill approach could eradicate barrier to curing HIV

New shock-and-kill approach could eradicate barrier to curing HIV

Despite tremendous progress in combatting HIV-1 infection with antiretroviral therapy, there is still no cure for the disease because these drugs do not kill a hidden reservoir of infected cells in the body. Continue reading

Dimethyl fumarate for MS: Added benefit not proven

Dimethyl fumarate for MS: Added benefit not proven

Dimethyl fumarate (trade name: Tecfidera) has been approved since January 2014 for adults with relapsing remitting multiple sclerosis (RRMS). In an early benefit assessment pursuant to the Act on the Reform of the Market for Medicinal Products (AMNOG), the German Institute for Quality and Efficiency in Health Care (IQWiG) has examined whether this new drug for MS offers an added benefit over the appropriate comparator therapy specified by the Federal Joint Committee (G-BA). However, no added benefit can be determined, as no suitable data are available, neither for the direct nor for the indirect comparison. Continue reading

Brief counseling for drug use doesn’t work

Brief counseling for drug use doesn’t work

In an effort to stem substance use, the U.S. has invested heavily in the past decade in a brief screening-and-intervention protocol for alcohol and other drugs. But a new study by Boston University School of Public Health and School of Medicine researchers casts doubt on whether that approach, which has proven successful with risky alcohol use, works for illicit drugs Continue reading

Causes of death shifting in people with HIV

Causes of death shifting in people with HIV

HIV-positive adults in high income countries face a substantially reduced risk of death from AIDS-related causes, cardiovascular disease, and liver disease compared with a decade ago, according to a large international study published in The Lancet. The study which involved nearly 50,000 HIV-positive adults receiving care and antiretroviral therapy (ART) at more than 200 clinics across Europe, USA, and Australia found that overall death rates have almost halved since 1999, while deaths due to AIDS-related causes and cardiovascular disease have declined by around 65% and liver-related deaths by more than 50%. Although deaths from most causes declined over the study period, there was no reduction in death rates from non-AIDS cancers which remained stable over time (1.6 deaths per 1000 years 1999-2000 to 2.1 in 2009-2011) Continue reading

One injection stops diabetes in its tracks: Treatment reverses symptoms of type 2 diabetes in mice without side effects

One injection stops diabetes in its tracks: Treatment reverses symptoms of type 2 diabetes in mice without side effects

In mice with diet-induced diabetes — the equivalent of type 2 diabetes in humans — a single injection of the protein FGF1 is enough to restore blood sugar levels to a healthy range for more than two days. The discovery by Salk scientists, published today in the journal Nature , could lead to a new generation of safer, more effective diabetes drugs Continue reading

One injection stops diabetes in its tracks: Treatment reverses symptoms of type 2 diabetes in mice without side effects

One injection stops diabetes in its tracks: Treatment reverses symptoms of type 2 diabetes in mice without side effects

In mice with diet-induced diabetes — the equivalent of type 2 diabetes in humans — a single injection of the protein FGF1 is enough to restore blood sugar levels to a healthy range for more than two days. The discovery by Salk scientists, published today in the journal Nature , could lead to a new generation of safer, more effective diabetes drugs Continue reading

Marijuana dependence alters the brain’s response to drug paraphernalia

Marijuana dependence alters the brain’s response to drug paraphernalia

New research from The University of Texas at Dallas demonstrates that drug paraphernalia triggers the reward areas of the brain differently in dependent and non-dependent marijuana users. The study, published July 1 in Drug and Alcohol Dependence , demonstrated that different areas of the brain activated when dependent and non-dependent users were exposed to drug-related cues. The 2012 National Survey on Drug Use and Health shows marijuana is the most widely used illicit drug in the United States Continue reading