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Tag Archives: Drugs

Finding safe drugs to treat neurodegenerative diseases

Finding safe drugs to treat neurodegenerative diseases

People diagnosed with Huntington’s disease, most in their mid-thirties and forties, face a devastating prognosis: complete mental, physical, and behavioral decline within two decades. “Mutant” protein clusters, long blamed for the progression of the genetic disease, have been the primary focus of therapies in development by pharmaceutical companies Continue reading

Cancer drugs block dementia-linked brain inflammation, study finds

Cancer drugs block dementia-linked brain inflammation, study finds

A class of drugs developed to treat immune-related conditions and cancer — including one currently in clinical trials for glioblastoma and other tumors — eliminates neural inflammation associated with dementia-linked diseases and brain injuries, according to UC Irvine researchers. In their study, assistant professor of neurobiology & behavior Kim Green and colleagues discovered that the drugs, which can be delivered orally, eradicated microglia, the primary immune cells of the brain. These cells exacerbate many neural diseases, including Alzheimer’s and Parkinson’s, as well as brain injury Continue reading

Cancer drugs block dementia-linked brain inflammation, study finds

Cancer drugs block dementia-linked brain inflammation, study finds

A class of drugs developed to treat immune-related conditions and cancer — including one currently in clinical trials for glioblastoma and other tumors — eliminates neural inflammation associated with dementia-linked diseases and brain injuries, according to UC Irvine researchers. In their study, assistant professor of neurobiology & behavior Kim Green and colleagues discovered that the drugs, which can be delivered orally, eradicated microglia, the primary immune cells of the brain. These cells exacerbate many neural diseases, including Alzheimer’s and Parkinson’s, as well as brain injury. Continue reading

New mouse model could revolutionize research in Alzheimer’s disease

New mouse model could revolutionize research in Alzheimer’s disease

Alzheimer’s disease, the primary cause of dementia in the elderly, imposes a tremendous social and economic burden on modern society. Continue reading

Tamiflu & Relenza: How effective are they?

Tamiflu & Relenza: How effective are they?

Tamiflu (the antiviral drug oseltamivir) shortens symptoms of influenza by half a day, but there is no good evidence to support claims that it reduces admissions to hospital or complications of influenza. This is according to the updated Cochrane evidence review, published today by The Cochrane Collaboration, the independent, global healthcare research network and The BMJ Continue reading

Rilpivirine combination product in pretreated HIV-1 patients: Added benefit not proven

Rilpivirine combination product in pretreated HIV-1 patients: Added benefit not proven

The German Institute for Quality and Efficiency in Health Care (IQWiG) reassessed the antiviral drug combination rilpivirine/emtricitabine/tenofovir. In early 2012, the combination was approved for the treatment of adults infected with human immunodeficiency virus type 1 (HIV-1) who have not received previous antiretroviral treatment. Continue reading

Twenty Years Later: How Breast Cancer Risk Genes are Changing Patient Care

Twenty Years Later: How Breast Cancer Risk Genes are Changing Patient Care

In the mid-1990s, scientists for the first time were able to isolate and clone the BRCA1 and BRCA2 genes, mutations in which were thought to increase susceptibility to early onset breast and ovarian cancers. A new Perspective published last week in Science takes a look back at the last twenty years to show how the identification of these genes set in motion a firestorm of research aimed at exploring how genetic information can be used to create both standards of care and strategies for all patients at a high-risk of developing cancer. Much has been learned over the last twenty years and now, Penn Medicine’s Basser Research Center for BRCA — the first and only comprehensive BRCA-focused center of its kind — is at the forefront of the next generation of research about genetics and cancer risk, methods for risk reduction and prevention, and new cancer treatment therapies. Continue reading

Adult cancer drugs show promise against an aggressive childhood brain tumor

Adult cancer drugs show promise against an aggressive childhood brain tumor

The quest to improve survival of children with a high-risk brain tumor has led St. Jude Children’s Research Hospital investigators to two drugs already used to treat adults with breast, pancreatic, lung and other cancers Continue reading

Drugs fail to reawaken dormant HIV infection

Drugs fail to reawaken dormant HIV infection

Scientists at Johns Hopkins report that compounds they hoped would “wake up” dormant reservoirs of HIV inside immune system T cells — a strategy designed to reverse latency and make the cells vulnerable to destruction — have failed to do so in laboratory tests of such white blood cells taken directly from patients infected with HIV. “Despite our high hopes, none of the compounds we tested in HIV-infected cells taken directly from patients activated the latent virus,” says Robert F. Continue reading

Drugs fail to reawaken dormant HIV infection

Drugs fail to reawaken dormant HIV infection

Scientists at Johns Hopkins report that compounds they hoped would “wake up” dormant reservoirs of HIV inside immune system T cells — a strategy designed to reverse latency and make the cells vulnerable to destruction — have failed to do so in laboratory tests of such white blood cells taken directly from patients infected with HIV. “Despite our high hopes, none of the compounds we tested in HIV-infected cells taken directly from patients activated the latent virus,” says Robert F. Continue reading