List/Grid

Tag Archives: Genetics

Genetic risk for autism stems mostly from common genes

Genetic risk for autism stems mostly from common genes

Using new statistical tools, Carnegie Mellon University’s Kathryn Roeder has led an international team of researchers to discover that most of the genetic risk for autism comes from versions of genes that are common in the population rather than from rare variants or spontaneous glitches. Published in the July 20 issue of the journal Nature Genetics , the study found that about 52 percent of autism was traced to common genes and rarely inherited variations, with spontaneous mutations contributing a modest 2.6 percent of the total risk Continue reading

Genetic cause of common breast tumors found

Genetic cause of common breast tumors found

A multi-disciplinary team of scientists from the National Cancer Centre Singapore, Duke-NUS Graduate Medical School Singapore, and Singapore General Hospital have made a major breakthrough in understanding the molecular basis of fibroadenoma, one of the most common breast tumors diagnosed in women. Continue reading

Genetic variations may modify cardiovascular benefit of aspirin

Genetic variations may modify cardiovascular benefit of aspirin

Aspirin is the gold standard for antiplatelet therapy and a daily low-dose aspirin is widely prescribed for the prevention of cardiovascular disease. Now, a new study suggests that common genetic variation in the gene for catechol-O-methyltransferase (COMT) may modify the cardiovascular benefit of aspirin, and in some people, may confer slight harm Continue reading

Adolescent alcohol abuse disrupts transitions into early adulthood

Adolescent alcohol abuse disrupts transitions into early adulthood

Prior research has shown strong associations between adolescent alcohol abuse and adverse outcomes in early adulthood. A first-of-its-kind study of linkages between adolescent alcohol abuse and adverse adult outcomes has examined the influence of differences in familial background and shared genetics on this association; findings are consistent with a causal relationship between adolescent drinking and subsequent alcohol-related adult problems that cannot be fully explained by shared genetic and environmental liabilities. Results will be published in the August 2014 online-only issue of Alcoholism: Clinical & Experimental Research and are currently available at Early View Continue reading

Gene that plays a surprising role in combating aging identified

Gene that plays a surprising role in combating aging identified

It is something of an eternal question: Can we slow or even reverse the aging process? Even though genetic manipulations can, in fact, alter some cellular dynamics, little is known about the mechanisms of the aging process in living organisms. Continue reading

Transplanting gene into injured hearts creates biological pacemakers

Transplanting gene into injured hearts creates biological pacemakers

Cardiologists at the Cedars-Sinai Heart Institute have developed a minimally invasive gene transplant procedure that changes unspecialized heart cells into “biological pacemaker” cells that keep the heart steadily beating. The laboratory animal research, published online and in today’s print edition of the peer-reviewed journal Science Translational Medicine , is the result of a dozen years of research with the goal of developing biological treatments for patients with heart rhythm disorders who currently are treated with surgically implanted pacemakers. Continue reading

Effects of starvation can be passed to future generations, through small RNAs apparently without DNA involvement

Effects of starvation can be passed to future generations, through small RNAs apparently without DNA involvement

Evidence from human famines and animal studies suggests that starvation can affect the health of descendants of famished individuals. But how such an acquired trait might be transmitted from one generation to the next has not been clear Continue reading

Preventing heart disease in New York City children and their caregivers

Preventing heart disease in New York City children and their caregivers

Mount Sinai Heart at Icahn School of Medicine at Mount Sinai has been awarded a $3.8 million grant by the American Heart Association (AHA) to promote cardiovascular health among high-risk New York City children, and their parents, living in Harlem and the Bronx. With assistance from the NYC Administration for Children’s Services (ACS), the research team’s mission is to reduce each child’s future risk of obesity, heart attack, stroke, and type 2 diabetes Continue reading

Likely origin of lung fungus invading Pacific Northwest found by study

Likely origin of lung fungus invading Pacific Northwest found by study

Cryptococcus gattii , a virulent fungus that has invaded the Pacific Northwest is highly adaptive and warrants global “public health vigilance,” according to a study by an international team led by the Translational Genomics Research Institute (TGen). C. gattii , which likely originated in Brazil, is responsible for dozens of deaths in recent years since it was first found in 1999 on Vancouver Island, British Columbia, Canada, well outside its usual tropical habitats Continue reading

Genome-wide analysis reveals genetic similarities among friends: Study finds truth to ‘friends are the family you choose’

Genome-wide analysis reveals genetic similarities among friends: Study finds truth to ‘friends are the family you choose’

If you consider your friends family, you may be on to something. A study from the University of California, San Diego, and Yale University finds that friends who are not biologically related still resemble each other genetically. Continue reading