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Tag Archives: Genetics

Development of new cell models that report circadian clock function

Development of new cell models that report circadian clock function

Researchers at the University of Memphis and University of Pennsylvania report the development of robust new liver and fat cell models that report circadian clock function. These models are amenable to high throughput drug screening and could be used to find promising small molecules to resynchronize or help body clocks function normally. The consequences of modern life, eating and staying up later, shift work, cell phone addiction, and travel across time zones, all disturb internal clocks. Continue reading

Transcription factors distinguishing glioblastoma stem cells identified

Transcription factors distinguishing glioblastoma stem cells identified

The activity of four transcription factors — proteins that regulate the expression of other genes — appears to distinguish the small proportion of glioblastoma cells responsible for the aggressiveness and treatment resistance of the deadly brain tumor. The findings by a team of Massachusetts General Hospital (MGH) investigators, which will be published in the April 24 issue of Cell and are receiving advance online release, support the importance of epigenetics — processes controlling whether or not genes are expressed — in cancer pathology and identify molecular circuits that may be targeted by new therapeutic approaches. Continue reading

Hope for children with previously incurable brain cancer

Hope for children with previously incurable brain cancer

Imagine the anguish of a parent whose child is diagnosed with an incurable form of childhood brain cancer. Surgery is not an option, current chemotherapy is ineffective and focal radiation only provides temporary relief. Remarkably, researchers from the Department of Laboratory Medicine and Pathobiology (LMP) have defined potential treatment targets for this relatively common cancer — providing hope for future patients Continue reading

Hope for children with previously incurable brain cancer

Hope for children with previously incurable brain cancer

Imagine the anguish of a parent whose child is diagnosed with an incurable form of childhood brain cancer. Continue reading

Gene sequencing project discovers mutations tied to deadly brain tumors in young children

Gene sequencing project discovers mutations tied to deadly brain tumors in young children

The St. Jude Children’s Research Hospital-Washington University Pediatric Cancer Genome Project has identified new mutations in pediatric brain tumors known as high-grade gliomas (HGGs), which most often occur in the youngest patients Continue reading

Gene sequencing project discovers mutations tied to deadly brain tumors in young children

Gene sequencing project discovers mutations tied to deadly brain tumors in young children

The St. Jude Children’s Research Hospital-Washington University Pediatric Cancer Genome Project has identified new mutations in pediatric brain tumors known as high-grade gliomas (HGGs), which most often occur in the youngest patients Continue reading

Parental obesity and autism risk in the child: Is paternal obesity a greater risk factor than maternal obesity?

Parental obesity and autism risk in the child: Is paternal obesity a greater risk factor than maternal obesity?

Several studies have looked at possible links between maternal obesity during pregnancy and the risk of developmental disorders in the child. However, paternal obesity could be a greater risk factor than maternal obesity, according to a new study from the Norwegian Institute of Public Health. As the first researcher to study the role of paternal obesity in autism, Dr. Continue reading

Potential drug targets in deadly pediatric brain tumors

Potential drug targets in deadly pediatric brain tumors

Researchers studying a rare, always fatal brain tumor in children have found several molecular alterations that drive the cancer, according to a new study from scientists at Dana-Farber/Boston Children’s Cancer and Blood Disorders Center and McGill University. The findings identify potential new targets for drug treatments. The new research could help physicians choose targeted agents with a better chance of combating pediatric high-grade astrocytomas, which are extremely difficult to treat with radiation and surgery Continue reading

The long and the short of telomeres: Loneliness impacts DNA repair, parrot study shows

The long and the short of telomeres: Loneliness impacts DNA repair, parrot study shows

Scientists at the Vetmeduni Vienna examined the telomere length of captive African grey parrots. They found that the telomere lengths of single parrots were shorter than those housed with a companion parrot, which supports the hypothesis that social stress can interfere with cellular aging and a particular type of DNA repair Continue reading