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Tag Archives: Genetics

New target for prostate cancer resistant to anti-hormone therapies

New target for prostate cancer resistant to anti-hormone therapies

Prostate cancer becomes deadly when anti-hormone treatments stop working. Now a new study suggests a way to block the hormones at their entrance Continue reading

New patenting guidelines needed for biotechnology

New patenting guidelines needed for biotechnology

Biotechnology scientists must be aware of the broad patent landscape and push for new patent and licensing guidelines, according to a new paper from Rice University’s Baker Institute for Public Policy. Published in the current issue of the journal Regenerative Medicine , the paper is based on the June 2013 U.S Continue reading

Applying math to biology: Software identifies disease-causing mutations in undiagnosed illnesses

Applying math to biology: Software identifies disease-causing mutations in undiagnosed illnesses

A computational tool developed at the University of Utah (U of U) has successfully identified diseases with unknown gene mutations in three separate cases, U of U researchers and their colleagues report in a new study in The American Journal of Human Genetics . The software, Phevor (Phenotype Driven Variant Ontological Re-ranking tool), identifies undiagnosed illnesses and unknown gene mutations by analyzing the exomes, or areas of DNA where proteins that code for genes are made, in individual patients and small families. Sequencing the genomes of individuals or small families often produces false predictions of mutations that cause diseases. Continue reading

Deadly human pathogen Cryptococcus fully sequenced

Deadly human pathogen Cryptococcus fully sequenced

Within each strand of DNA lies the blueprint for building an organism, along with the keys to its evolution and survival. These genetic instructions can give valuable insight into why pathogens like Cryptococcus neoformans — a fungus responsible for a million cases of pneumonia and meningitis every year — are so malleable and dangerous Continue reading

Development of new cell models that report circadian clock function

Development of new cell models that report circadian clock function

Researchers at the University of Memphis and University of Pennsylvania report the development of robust new liver and fat cell models that report circadian clock function. These models are amenable to high throughput drug screening and could be used to find promising small molecules to resynchronize or help body clocks function normally. The consequences of modern life, eating and staying up later, shift work, cell phone addiction, and travel across time zones, all disturb internal clocks. Continue reading

Transcription factors distinguishing glioblastoma stem cells identified

Transcription factors distinguishing glioblastoma stem cells identified

The activity of four transcription factors — proteins that regulate the expression of other genes — appears to distinguish the small proportion of glioblastoma cells responsible for the aggressiveness and treatment resistance of the deadly brain tumor. The findings by a team of Massachusetts General Hospital (MGH) investigators, which will be published in the April 24 issue of Cell and are receiving advance online release, support the importance of epigenetics — processes controlling whether or not genes are expressed — in cancer pathology and identify molecular circuits that may be targeted by new therapeutic approaches. Continue reading

Hope for children with previously incurable brain cancer

Hope for children with previously incurable brain cancer

Imagine the anguish of a parent whose child is diagnosed with an incurable form of childhood brain cancer. Surgery is not an option, current chemotherapy is ineffective and focal radiation only provides temporary relief. Remarkably, researchers from the Department of Laboratory Medicine and Pathobiology (LMP) have defined potential treatment targets for this relatively common cancer — providing hope for future patients Continue reading

Hope for children with previously incurable brain cancer

Hope for children with previously incurable brain cancer

Imagine the anguish of a parent whose child is diagnosed with an incurable form of childhood brain cancer. Continue reading

Gene sequencing project discovers mutations tied to deadly brain tumors in young children

Gene sequencing project discovers mutations tied to deadly brain tumors in young children

The St. Jude Children’s Research Hospital-Washington University Pediatric Cancer Genome Project has identified new mutations in pediatric brain tumors known as high-grade gliomas (HGGs), which most often occur in the youngest patients Continue reading