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Tag Archives: German

Ciliopathies: New insights into development

Ciliopathies: New insights into development

To date, it is still not clear how proteins regulate planar cell polarity (PCP) or the positioning of the basal body (BB) and cilia. Continue reading

UN worker dies of Ebola in Germany

UN worker dies of Ebola in Germany

unable to retrieve full-text contentA UN health worker infected with Ebola dies at a hospital in the German city of Leipzig, hospital officials say. Continue reading

Fingolimod in new therapeutic indication: Added benefit not proven, study finds

Fingolimod in new therapeutic indication: Added benefit not proven, study finds

The immunosuppressive drug fingolimod (trade name: Gilenya) was approved for an expanded therapeutic indication in May 2014: It is now also available for adults with highly active relapsing remitting multiple sclerosis (RRMS) who had received other pretreatment than interferon beta (IFN-β). In an early benefit assessment pursuant to the Act on the Reform of the Market for Medicinal Products (AMNOG), the German Institute for Quality and Efficiency in Health Care (IQWiG) examined whether the drug offers an added benefit over the appropriate comparator therapy in this patient group. According to the findings, such an added benefit is not proven: For some of the patients, the drug manufacturer presented no data Continue reading

A diet for the cell: Keeping DNA fit with fewer calories

A diet for the cell: Keeping DNA fit with fewer calories

Cells are generally able to repair spontaneous damage that arises in their genetic material. Unfortunately, the DNA repair process is not perfect and sometimes, damaged DNA gets passed on to newly made cells Continue reading

One in three people with cancer has anxiety or other mental health challenges

One in three people with cancer has anxiety or other mental health challenges

Researchers in Germany report that nearly a third of more than 2,100 patients with cancer interviewed at inpatient and outpatient care centers experienced a clinically meaningful level of mental or emotional distress that meets the strict diagnostic criteria for mental disorders including anxiety, depressive and adjustment disorders during the prior four weeks. Continue reading

Dengue fever, malaria in the Himalayas

Dengue fever, malaria in the Himalayas

Research by Nepalese and German scientists from the Nepal Health Research Council, Goethe University and the LOEWE Biodiversity and Climate Research Centre analyzes the current situation of these diseases in the Himalayan country of Nepal and highlights how they profit from climate change and globalization. Dengue fever: high risk, little knowledge Although the first case of dengue fever in Nepal was only reported in 2004, the country was shaken by an epidemic already in 2010 Continue reading

Brain development in schizophrenia strays from normal path

Brain development in schizophrenia strays from normal path

Schizophrenia is generally considered to be a disorder of brain development and it shares many risk factors, both genetic and environmental, with other neurodevelopmental disorders such as autism and intellectual disability. The normal path for brain development is determined by the combined effects of a complex network of genes and a wide range of environmental factors. Continue reading

Avatars make the Internet sign to deaf people

Avatars make the Internet sign to deaf people

It is challenging for deaf people to learn a sound-based language, since they are physically not able to hear those sounds. Hence, most of them struggle with written language as well as with text reading and comprehension. Continue reading

Perampanel for epilepsy: Still no proof of added benefit

Perampanel for epilepsy: Still no proof of added benefit

The drug perampanel (trade name Fycompa) has been approved since July 2012 as adjunctive (“add-on”) therapy for adults and children aged 12 years and older with epileptic fits (seizures). In a new early benefit assessment according to the Act on the Reform of the Market for Medicinal Products (AMNOG), the German Institute for Quality and Efficiency in Health Care (IQWiG) examined whether perampanel offers an added benefit over the appropriate comparator therapy. However, such an added benefit cannot be derived from the new dossier either, as the drug manufacturer did not submit any relevant data for this comparison Continue reading

Work-related stress a risk factor for type 2 diabetes

Work-related stress a risk factor for type 2 diabetes

Workplace stress can have a range of adverse effects on health with an increased risk of cardio-vascular diseases in the first line. However, to date, convincing evidence for a strong association between work stress and incident Type 2 diabetes mellitus is missing. Continue reading