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Tag Archives: German

Turoctocog alfa in patients with hemophilia A: Added benefit not proven

Turoctocog alfa in patients with hemophilia A: Added benefit not proven

Turoctocog alfa (trade name: NovoEight) has been approved since November 2013 for the prevention and treatment of bleeding in patients with hemophilia A. In an early benefit assessment pursuant to the “Act on the Reform of the Market for Medicinal Products” (AMNOG), the German Institute for Quality and Efficiency in Health Care (IQWiG) examined whether this new active ingredient offers an added benefit over the appropriate comparator therapy Continue reading

Researchers identify a new variant of Ebola virus in Guinea

Researchers identify a new variant of Ebola virus in Guinea

In an article which appeared in The New England journal of Medicine on 16 April, researchers from Inserm (Jean Mérieux-Inserm BSL-4 Laboratory, Lyon) and the Institut Pasteur have published their initial findings on the characteristics of the Ebola virus discovered in Guinea. Initial virological investigations enabled them to identify Zaire ebolavirus as the pathogen responsible for this epidemic. Performed in less than a month, sequencing of the complete genome and subsequent phylogenetic analysis show that the virus present in Guinea forms a clade (variant) that is distinct from strains previously identified in the Democratic Republic of Congo and in Gabon. Continue reading

Immune cells to be tested on the International Space Station

Immune cells to be tested on the International Space Station

The human body is fine-tuned to Earth’s gravity. A team headed by Professor Oliver Ullrich from the University of Zurich’s Institute of Anatomy is now conducting an experiment on the International Space Station (ISS) to study whether this also applies to human cells Continue reading

Rilpivirine combination product in pretreated HIV-1 patients: Added benefit not proven

Rilpivirine combination product in pretreated HIV-1 patients: Added benefit not proven

The German Institute for Quality and Efficiency in Health Care (IQWiG) reassessed the antiviral drug combination rilpivirine/emtricitabine/tenofovir. In early 2012, the combination was approved for the treatment of adults infected with human immunodeficiency virus type 1 (HIV-1) who have not received previous antiretroviral treatment. Continue reading

Radium-223 dichloride in prostate cancer: Major added benefit for certain patients

Radium-223 dichloride in prostate cancer: Major added benefit for certain patients

Radium-223 dichloride (radium-223 for short, trade name: Xofigo) has been approved since November 2013 for men with advanced prostate cancer, in whom hormone blockade is no longer effective, and symptomatic bone metastases, but without visceral metastases. Continue reading

Technique measures quantity, risks of engineered nanomaterials delivered to cells

Technique measures quantity, risks of engineered nanomaterials delivered to cells

Thousands of consumer products containing engineered nanoparticles — microscopic particles found in everyday items from cosmetics and clothing to building materials — enter the market every year. Concerns about possible environmental health and safety issues of these nano-enabled products continue to grow with scientists struggling to come up with fast, cheap, and easy-to-use cellular screening systems to determine possible hazards of vast libraries of engineered nanomaterials. However, determining how much exposure to engineered nanoparticles could be unsafe for humans requires precise knowledge of the amount (dose) of nanomaterials interacting with cells and tissues such as lungs and skin Continue reading

Cholesterol transporter structure decoded

Cholesterol transporter structure decoded

The word “cholesterol” is directly linked in most people’s minds with high-fat foods, worrying blood test results, and cardiovascular diseases. However, despite its bad reputation, cholesterol is essential to our wellbeing: It stabilizes cell membranes and is a raw material for the production of different hormones in the cell’s power plants — the mitochondria Continue reading

Comeback of an abandoned antibiotic: Trimethoprim

Comeback of an abandoned antibiotic: Trimethoprim

Scarlet fever and infections of the skin and throat are often caused by a bacterium called Streptococcus pyogenes . Continue reading

Gene mutation immortalizes malignant melanoma

Gene mutation immortalizes malignant melanoma

Jan. 25, 2013 — Scientists from the German Cancer Research Center and from University Duisburg-Essen have discovered a previously unknown genetic cause of malignant melanoma: a gene mutation that leads to overactive telomerase, the so-called ‘immortality enzyme’. The mutated gene region found in familial melanoma is also altered in up to 74 percent of non-inherited cases of melanoma — here as a consequence of sun exposure. Continue reading

New treatment could combat deadly chemical agents

New treatment could combat deadly chemical agents

Jan. Continue reading