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Tag Archives: Immunology

Kawasaki disease in childhood linked to increased risk of adult heart disease

Kawasaki disease in childhood linked to increased risk of adult heart disease

ScienceDaily (July 17, 2012) — Cedars-Sinai researchers have linked Kawasaki Disease, a serious childhood illness that causes inflammation of blood vessels throughout the body, with early-onset and accelerated atherosclerosis, a leading cause of heart disease in adults. In a study published in the August 2012 print edition of Arteriosclerosis, Thrombosis, and Vascular Biology , an American Heart Association peer-reviewed medical journal, a team of researchers showed how Kawasaki Disease in young mice predisposed them to develop accelerated atherosclerosis, often called hardening of the arteries, in young adulthood. The study also suggests that aggressive early treatment of the blood vessel inflammation caused by Kawasaki Disease may reduce the future risk of developing accelerated atherosclerosis. Continue reading

Kawasaki disease in childhood linked to increased risk of adult heart disease

Kawasaki disease in childhood linked to increased risk of adult heart disease

ScienceDaily (July 17, 2012) — Cedars-Sinai researchers have linked Kawasaki Disease, a serious childhood illness that causes inflammation of blood vessels throughout the body, with early-onset and accelerated atherosclerosis, a leading cause of heart disease in adults. In a study published in the August 2012 print edition of Arteriosclerosis, Thrombosis, and Vascular Biology , an American Heart Association peer-reviewed medical journal, a team of researchers showed how Kawasaki Disease in young mice predisposed them to develop accelerated atherosclerosis, often called hardening of the arteries, in young adulthood. The study also suggests that aggressive early treatment of the blood vessel inflammation caused by Kawasaki Disease may reduce the future risk of developing accelerated atherosclerosis. Continue reading

How aging impairs immune response

How aging impairs immune response

ScienceDaily (July 17, 2012) — Researchers at Albert Einstein College of Medicine of Yeshiva University have uncovered one of the mechanisms by which aging may compromise the ability of the immune system to fight infections and respond to vaccines. The study, conducted in aging mice, shows that administering antioxidants may help reverse this loss of immune function. The findings were published online this month in the journal Cell Reports . Continue reading

£20m donation for Cancer research

£20m donation for Cancer research

17 July 2012 Last updated at 12:50 ET By Susan Watts Newsnight Science editor, BBC News A donor, who wishes to remain anonymous, has given £20m to fund cancer immunology in the UK, BBC’s Newsnight has learnt. Harnessing the immune system is seen as a promising new area of treatment, but raising funding has become harder. The money will be equally split between the Francis Crick Institute for medical research and University of Southampton. Continue reading

Critical cell in fighting E. coli infection identified

Critical cell in fighting E. coli infection identified

ScienceDaily (July 15, 2012) — Despite ongoing public health efforts, E. coli outbreaks continue to infiltrate the food supply, annually causing significant sickness and death throughout the world. But the research community is gaining ground Continue reading

New mechanism might promote cancer’s growth and spread in the body

New mechanism might promote cancer’s growth and spread in the body

ScienceDaily (July 10, 2012) — Tiny vesicles released by tumors cells are taken up by healthy immune cells, causing the immune cells to discharge chemicals that foster cancer-cell growth and spread, according to a study by researchers at The Ohio State University Comprehensive Cancer Center — Arthur G. James Cancer Hospital and Richard J. Continue reading

Lower iron levels seen in newborns of obese mothers

Lower iron levels seen in newborns of obese mothers

ScienceDaily (July 9, 2012) — A growing number of studies imply that children born to obese mothers face health problems stemming from the womb. New research from the Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University and The Mother Infant Research Institute at Tufts Medical Center suggests that low iron status is among these health problems, according to an analysis of maternal hepcidin, a hormone that is key in keeping iron levels balanced Continue reading

Epigenetics alters genes in rheumatoid arthritis

Epigenetics alters genes in rheumatoid arthritis

ScienceDaily (July 3, 2012) — It’s not just our DNA that makes us susceptible to disease and influences its impact and outcome. Scientists are beginning to realize more and more that important changes in genes that are unrelated to changes in the DNA sequence itself — a field of study known as epigenetics — are equally influential. A research team at the University of California, San Diego — led by Gary S. Continue reading

Immune system molecule weaves cobweb-like nanonets to snag Salmonella, other intestinal microbes

Immune system molecule weaves cobweb-like nanonets to snag Salmonella, other intestinal microbes

ScienceDaily (June 21, 2012) — A team of researchers led by UC Davis Health System has found that human alpha-defensin 6 (HD6) — a key component of the body’s innate defense system — binds to microbial surfaces and forms “nanonets” that surround, entangle and disable microbes, preventing bacteria from attaching to or invading intestinal cells. The research describes an entirely new mechanism of action for defensins, an important group of molecules known to bolster the defenses of circulating white blood cells, protect cellular borders from invasive pathogens and regulate which “friendly” microbes can colonize body surfaces. Continue reading

Timing, duration of biochemical bugle call critical for fighting viruses

Timing, duration of biochemical bugle call critical for fighting viruses

ScienceDaily (June 13, 2012) — Researchers have identified the primary player of the biochemical bugle call that musters the body’s defenders against viral infection. Scientists at Washington University School of Medicine in St. Louis have shown that a key molecule, MDA5, is essential for producing enough interferon (the bugle call) to rally virus-fighting cells during certain viral infections Continue reading