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Tag Archives: laboratory

Described novel regulator of protein inactive in over 50 percent of human tumors

Described novel regulator of protein inactive in over 50 percent of human tumors

Researchers at the Bellvitge Biomedical Research Institute (IDIBELL) and the University of Barcelona have discovered the interaction between HERC2 proteins with another protein called p53 that is inactivated in more than half of human tumors. The study results were published in the Journal of Biological Chemistry. Regulation of the activity of p53 by HERC2 The team of José Luis Rosa, at the growth factors and cell differentiation research group at IDIBELL studies the molecular mechanisms of HERC family proteins. Continue reading

New cellular garbage control pathway with relevance for human neurodegenerative diseases

New cellular garbage control pathway with relevance for human neurodegenerative diseases

Several human neurodegenerative diseases, including Alzheimer’s, Parkinson’s and Huntington’s disease but also aging, are linked to an accumulation of abnormal and aggregated proteins in cells. Cellular “garbage” of this type can be removed from cells by sweeping them to a cellular recycling station known as the lysosome Continue reading

Anti-tank missile detector joins fight against malaria

Anti-tank missile detector joins fight against malaria

State-of-the-art military hardware could soon fight malaria, one of the most deadly diseases on the planet. Researchers at Monash University and the University of Melbourne have used an anti-tank Javelin missile detector, more commonly used in warfare to detect the enemy, in a new test to rapidly identify malaria parasites in blood. Scientists say the novel idea, published in the journal Analyst , could set a new gold standard for malaria testing Continue reading

Health risks posed by ‘third hand’ tobacco smoke

Health risks posed by ‘third hand’ tobacco smoke

Research led by the University of York has highlighted the potential cancer risk in non-smokers — particularly young children — of tobacco smoke gases and particles deposited to surfaces and dust in the home. Until now, the risks of this exposure known as ‘third hand tobacco smoke’ have been highly uncertain and not considered in public policy. However, a new study published in the journal Environment International, has estimated for the first time the potential cancer risk by age group through non-dietary ingestion and dermal exposure to third hand smoke Continue reading

Study of noninvasive retinal imaging device presented at Alzheimer’s conference

Study of noninvasive retinal imaging device presented at Alzheimer’s conference

A noninvasive optical imaging device developed at Cedars-Sinai can provide early detection of changes that later occur in the brain and are a classic sign of Alzheimer’s disease, according to preliminary results from investigators conducting a clinical trial in Australia. The researchers will present their findings July 15 in an oral presentation at the Alzheimer’s Association International Conference 2014 in Copenhagen, Denmark. Continue reading

Stem cell scientists lay TRAP for disease

Stem cell scientists lay TRAP for disease

USC Stem Cell scientists have set a “mouse TRAP” to capture the early signs of kidney failure, as described by a recent study published in the Journal of Clinical Investigation . Their new transgenic mouse line uses a technique called TRAP to extract cellular and genetic information from a variety of solid organs. Invented by scientists at the Rockefeller Institute for Medical Research in 2008, TRAP involves attaching a fluorescent tag to the protein-making machinery, or ribosomes, of the cell type of interest Continue reading

Hydroxyethyl starch has direct harmful effects on kidney cells, lab study finds

Hydroxyethyl starch has direct harmful effects on kidney cells, lab study finds

The increased risk of kidney injury related to the use of hydroxyethyl starch (HES) in resuscitation fluids reflects the mass of HES molecules, according to a report in Anesthesia & Analgesia , official journal of the International Anesthesia Research Society (IARS). The “total mass of HES molecules” explains the harmful effect of HES on cultured human renal proximal tubule cells (PTCs), concludes the laboratory study by Dr Christian Wunder and colleagues of University Hospital Würzburg, Austria. Other factors — such as differences in the origin or molecular weight of HES solutions — appear to play little or no role in cellular-level toxicity of HES. Continue reading

Stem cell researcher targets ‘seeds’ of breast cancer metastasis

Stem cell researcher targets ‘seeds’ of breast cancer metastasis

For breast cancer patients, the era of personalized medicine may be just around the corner, thanks to recent advances by USC Stem Cell researcher Min Yu and scientists at Massachusetts General Hospital and Harvard Medical School. In a July 11 study in Science , Yu and her colleagues report how they isolated breast cancer cells circulating through the blood streams of six patients. Some of these deadly cancer cells are the “seeds” of metastasis, which travel to and establish secondary tumors in vital organs such as the bone, lungs, liver and brain. Continue reading

Cellular defense against fatal associations between proteins and DNA

Cellular defense against fatal associations between proteins and DNA

DNA — the carrier of genetic information — is constantly threatened by damage originating from exogenous and endogenous sources. Very special DNA lesions are DNA-protein crosslinks — proteins covalently linked to DNA. Continue reading

Fondue with chicken causes campylobacter infections in Switzerland

Fondue with chicken causes campylobacter infections in Switzerland

Meat fondue with chicken is one of the primary risk factors for a campylobacter infection in Switzerland in winter, a new study shows. At the end of each year, the reported case numbers of this severe intestinal infection increase in Switzerland Continue reading