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Tag Archives: laboratory

Details of calcium ‘safety-valve’ in cells explained

Details of calcium ‘safety-valve’ in cells explained

Sometimes a cell has to die — when it’s done with its job or inflicted with injury that could otherwise harm an organism. Conversely, cells that refuse to die when expected can lead to cancer. So scientists interested in fighting cancer have been keenly interested in learning the details of “programmed cell death.” They want to understand what happens when this process goes awry and identify new targets for anticancer drugs. Continue reading

New targets that could increase effectiveness, reduce side effects in breast cancer treatments

New targets that could increase effectiveness, reduce side effects in breast cancer treatments

Scientists from the Florida campus of The Scripps Research Institute (TSRI) have found new targets for potential intervention in breast cancer. Continue reading

Why are older women more vulnerable to breast cancer? New clues

Why are older women more vulnerable to breast cancer? New clues

Scientists from the Department of Energy’s Lawrence Berkeley National Laboratory (Berkeley Lab) have gained more insights into why older women are more susceptible to breast cancer. They found that as women age, the cells responsible for maintaining healthy breast tissue stop responding to their immediate surroundings, including mechanical cues that should prompt them to suppress nearby tumors. Their work sheds light on how aging alters cellular and molecular functions, and how these changes contribute to the prevalence of breast cancer in older women Continue reading

Molecular secret of short, intense workouts clarified

Molecular secret of short, intense workouts clarified

In the last few years, the benefits of short, intense workouts have been extolled by both researchers and exercise fans as something of a metabolic panacea capable of providing greater overall fitness, better blood sugar control and weight reduction — all of it in periods as short as seven minutes a few times a week. Now, in a new study, scientists from the Florida campus of The Scripps Research Institute (TSRI) confirm that there is something molecularly unique about intense exercise: the activation of a single protein. Continue reading

Hemorrhagic Fevers Can Be Caused by Body’s Antiviral Interferon Response

Hemorrhagic Fevers Can Be Caused by Body’s Antiviral Interferon Response

Hemorrhagic fevers caused by Lassa, dengue and other viruses affect more than one million people annually and are often fatal, yet scientists have never understood why only some virus-infected people come down with the disease and others do not. But now, virologists and immunologists at The Scripps Research Institute (TSRI) have found a major clue to the mystery of “hemorrhagic fever” syndromes. In findings reported this week in an Early Edition of the Proceedings of the National Academy of Sciences , the team showed that Interferon Type I (IFN-I) immune proteins are key drivers of a viral syndrome in mice that closely mimics these human hemorrhagic fevers Continue reading

Prototype electrolyte sensor to provide immediate read-outs: Painless wearable microneedle device may reduce trips to doctors’ offices

Prototype electrolyte sensor to provide immediate read-outs: Painless wearable microneedle device may reduce trips to doctors’ offices

Patients trying to navigate today’s complex medical system with its costly laboratory analyses might prefer a pain-free home diagnostic device, worn on the wrist, that can analyze, continuously record and immediately remedy low electrolyte levels. Continue reading

Humans’ tiny cellular machines: Spliceosomes in detail

Humans’ tiny cellular machines: Spliceosomes in detail

A grandfather clock is, on its surface, a simple yet elegant machine. Tall and stately, its job is to steadily tick away the time. Continue reading

Subtle change in DNA, protein levels determines blond or brunette tresses, study finds

Subtle change in DNA, protein levels determines blond or brunette tresses, study finds

A molecule critical to stem cell function plays a major role in determining human hair color, according to a study from the Stanford University School of Medicine. The study describes for the first time the molecular basis for one of our most noticeable traits. Continue reading

Responses with crizotinib in MET-amplified lung cancer show new targetable form of disease

Responses with crizotinib in MET-amplified lung cancer show new targetable form of disease

A study presented at the American Society of Clinical Oncology (ASCO) Annual Meeting 2014 reports the results of a first-in-human, phase 1 dose escalation trial of crizotinib (XALKORI) in 14 patients with advanced, MET-amplified non-small cell lung cancer (NCT00585195). In 2011, the drug crizotinib earned accelerated approval by the US FDA to target the subset of advanced non-small cell lung cancers caused by rearrangements of the anaplastic lymphoma kinase (ALK) gene, and subsequently was granted regular approval in 2013 Continue reading

Researchers see stem cells take key step toward development: A first

Researchers see stem cells take key step toward development: A first

The gap between stem cell research and regenerative medicine just became a lot narrower, thanks to a new technique that coaxes stem cells, with potential to become any tissue type, to take the first step to specialization. It is the first time this critical step has been demonstrated in a laboratory. University of Illinois researchers, in collaboration with scientists at Notre Dame University and the Huazhong University of Science and Technology in China, published their results in the journal Nature Communications Continue reading