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Tag Archives: London

Genetic variants influence a person’s response to statins found

Genetic variants influence a person’s response to statins found

A large analysis of over 40,000 individuals on statin treatment has identified two new genetic variants which influence how ‘bad’ cholesterol levels respond to statin therapy. Statins are widely prescribed to patients and have been shown to lower bad cholesterol levels by up to 55%, making them a highly effective method of reducing risk of heart disease. Continue reading

How lymph nodes expand during disease

How lymph nodes expand during disease

CANCER RESEARCH UK and UCL scientists have discovered that the same specialised immune cells that patrol the body and spot infections also trigger the expansion of immune organs called lymph nodes, according to a study published in Nature . Continue reading

Treatment for osteoporosis, bone cancer, employed for the first time in dental filling procedures

Treatment for osteoporosis, bone cancer, employed for the first time in dental filling procedures

Journal of Dental Research publishes a paper directed by Salvatore Sauro, Professor at University CEU Cardenal Herrera in Spain, in collaboration with international researchers from Finland, Brazil, United States and United Kingdom. The research report has demonstrated how the use of zoledronic acid, in combination with bioactive ion-releasing resin-based restorative materials used as dental adhesive, reduces the degradation of dentin collagen and promotes remineralisation at the resin-dentine interface. Continue reading

Call for Trafalgar Square smoking ban

Call for Trafalgar Square smoking ban

unable to retrieve full-text contentSmoking could be banned in Trafalgar and Parliament squares as well as the city’s parks if a report by London’s Health Commission is implemented. Continue reading

New cancer drug to begin trials in multiple myeloma patients

New cancer drug to begin trials in multiple myeloma patients

Scientists at Imperial College London have developed a new cancer drug which they plan to trial in multiple myeloma patients by the end of next year. In a paper published today in the journal Cancer Cell , the researchers report how the drug, known as DTP3, kills myeloma cells in laboratory tests in human cells and mice, without causing any toxic side effects, which is the main problem with most other cancer drugs. The new drug works by stopping a key process that allows cancer cells to multiply Continue reading

Ebola screening not perfect – Boris

Ebola screening not perfect – Boris

unable to retrieve full-text contentThe government is at risk of promising “stuff that doesn’t really make any sense” in its plans to prevent Ebola reaching the UK, London Mayor Boris Johnson says. Continue reading

New meningitis vaccine only cost-effective at low price

New meningitis vaccine only cost-effective at low price

Bexsero is the first vaccine to broadly protect against meningitis B disease, but research now suggests the Government would need to negotiate a considerable reduction in the £75 list price in order to provide the same value for money as other programmes in the NHS. In March 2014, the Joint Committee on Vaccination and Immunisation (JCVI), the independent expert group that advises UK governments on vaccination, recommended that Bexsero be offered to babies at two, four and 12 months of age as long as the Department of Health can obtain the vaccine at a cost-effective price Continue reading

New vaccines targeting adults, teens are best chance to eliminate TB by 2050

New vaccines targeting adults, teens are best chance to eliminate TB by 2050

Targets to eliminate tuberculosis (TB) by 2050 are more likely to be met if new vaccines are developed for adults and adolescents instead of for infants, according to new research published in the journal Proceedings of the National Academy of Sciences . Continue reading

Customizing chemotherapy in lung cancer: New phase II data reported

Customizing chemotherapy in lung cancer: New phase II data reported

Measuring the expression levels of an enzyme involved in DNA synthesis can help predict the response of lung cancers to certain treatments, a Korean study has shown at the ESMO 2014 Congress in Madrid. In a randomized phase II study, researchers showed that patients whose lung cancers expressed low levels of an enzyme called thymidylate synthase experienced a greater benefit from treatment with the combination of pemetrexed and cisplatin than those whose tumours expressed high levels. “Thymidylate synthase is one of the proteins that is targeted by pemetrexed which is the most widely used chemotherapeutic regimen in the treatment of non-squamous NSCLC,” explains study author Professor Myung-Ju Ahn, from the Section of Hematology-Oncology at Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea. Continue reading

Severe periodontitis: Sixth most prevalent health condition in the world

Severe periodontitis: Sixth most prevalent health condition in the world

The International and American Associations for Dental Research (IADR/AADR) have published a paper titled “Global Burden of Periodontitis: A Systematic Review and Meta-Regression.” The manuscript, by lead researcher Wagner Marcenes (Queen Mary University of London, Institute of Dentistry, Barts and The London School) is published in the OnlineFirst portion of the IADR/AADR Journal of Dental Research ( JDR ). The purpose of this study was to consolidate all epidemiological data about severe periodontitis and subsequently to generate internally consistent prevalence and incidence estimates for all countries, 20 age groups, and both sexes for 1990 and 2010. From the systematic search, a total of 72 qualifying studies involving 291,170 individuals aged 15 years or older from 37 countries were included in the meta-regression using modeling resources of the Global Burden of Disease (GBD) 2010 Study. Continue reading