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Kidney dialysis machine invented for babies, safely treat newborn with multiple organ failure in world first breakthrough

Kidney dialysis machine invented for babies, safely treat newborn with multiple organ failure in world first breakthrough

Italian scientists have developed a miniaturized kidney dialysis machine capable of treating the smallest babies, and have for the first time used it to safely treat a newborn baby with multiple organ failure. This technology has the potential to revolutionize the treatment of infants with acute kidney injury, according to new research published in The Lancet . The new continuous renal replacement therapy (CRRT) machine — named CARPEDIEM (Cardio-Renal Pediatric Dialysis Emergency Machine) — was created to overcome the problems of existing dialysis machines that are only designed for adults and have to be adapted for use in newborns and small infants. Continue reading

Misguided DNA-repair proteins caught in the act

Misguided DNA-repair proteins caught in the act

Accumulation of DNA damage can cause aggressive forms of cancer and accelerated aging, so the body’s DNA repair mechanisms are normally key to good health. However, in some diseases the DNA repair machinery can become harmful Continue reading

Misguided DNA-repair proteins caught in the act

Misguided DNA-repair proteins caught in the act

Accumulation of DNA damage can cause aggressive forms of cancer and accelerated aging, so the body’s DNA repair mechanisms are normally key to good health. However, in some diseases the DNA repair machinery can become harmful Continue reading

Weak chemical forces combined to strengthen novel imaging technology

Weak chemical forces combined to strengthen novel imaging technology

When Associate Professor of Chemical and Biomolecular Engineering Hyunjoon Kong, graduate student Cartney Smith, and colleagues set out to improve MR imaging (MRI), they turned current contrast agent technology on its head — or rather, they turned it inside out. The new compound they designed in collaboration with Roger Adams Professor of Chemistry Steven C. Zimmerman is not only more effective, but also self-assembling. Continue reading

Adults who lose weight at any age could enjoy improved cardiovascular health

Adults who lose weight at any age could enjoy improved cardiovascular health

Weight loss at any age in adulthood is worthwhile because it could yield long-term heart and vascular benefits, suggests new research published in The Lancet Diabetes & Endocrinology . The findings are from a study examining the impact of lifelong patterns of weight change on cardiovascular risk factors in a group of British men and women followed since birth in March 1946. They showed that the longer the exposure to excess body fat (adiposity) in adulthood the greater the cardiovascular-related problems in later life, including increased thickness of the carotid artery walls, raised systolic blood pressure, and increased risk of diabetes. Continue reading

Biomarker test for Peripartum Cardiomyopathy could help reduce death after giving birth

Biomarker test for Peripartum Cardiomyopathy could help reduce death after giving birth

Cardiologists have discovered biomarkers that can be used to develop a screening test to detect Peripartum Cardiomyopathy (PPCM), a life-threatening disorder that is the primary cause of mortality in pregnant women in developing countries. The results, which can lead to the immediate treatment of PPCM in new mothers and a significant reduction in mortality, were presented at Heart Failure 2014, which opened the World Congress on Acute Heart Failure in Athens the 17 to the 20 May. Continue reading

Poor diuretic response associated with worse clinical outcomes

Poor diuretic response associated with worse clinical outcomes

Poor diuretic response is associated with worse in-hospital and post-discharge clinical outcomes, results of the RELAX-AHF trial reveal. The study also found that serelaxin has a neutral effect on diuretic response. These novel data from the RELAX-AHF trial were presented by lead author Professor Adriaan A Continue reading

Ground breaking hip and stem cell surgery completed using 3D printed implant

Ground breaking hip and stem cell surgery completed using 3D printed implant

Doctors and scientists in Southampton have completed their first hip surgery with a 3D printed implant and bone stem cell graft. The 3D printed hip, made from titanium, was designed using the patient’s CT scan and CAD CAM (computer aided design and computer aided manufacturing) technology, meaning it was designed to the patient’s exact specifications and measurements. The implant will provide a new socket for the ball of the femur bone to enter. Continue reading

Plugging leaky blood vessels to save vision

Plugging leaky blood vessels to save vision

A new drug approach has been developed for safer clean-up of deformed blood vessels in the eye by a research team at the Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital in Toronto. The growth of malformed blood vessels that can burst is a leading cause of vision loss in North America. Retinopathy and retina degeneration are associated with premature birth, with diabetes, and with increasing age. Continue reading

Plugging leaky blood vessels to save vision

Plugging leaky blood vessels to save vision

A new drug approach has been developed for safer clean-up of deformed blood vessels in the eye by a research team at the Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital in Toronto. The growth of malformed blood vessels that can burst is a leading cause of vision loss in North America. Retinopathy and retina degeneration are associated with premature birth, with diabetes, and with increasing age. Continue reading