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Chemotherapy timing is key to success, research shows

Chemotherapy timing is key to success, research shows

MIT researchers have devised a novel cancer treatment that destroys tumor cells by first disarming their defenses, then hitting them with a lethal dose of DNA damage. In studies with mice, the research team showed that this one-two punch, which relies on a nanoparticle that carries two drugs and releases them at different times, dramatically shrinks lung and breast tumors. The MIT team, led by Michael Yaffe, the David H Continue reading

Chemotherapy timing is key to success, research shows

Chemotherapy timing is key to success, research shows

MIT researchers have devised a novel cancer treatment that destroys tumor cells by first disarming their defenses, then hitting them with a lethal dose of DNA damage. In studies with mice, the research team showed that this one-two punch, which relies on a nanoparticle that carries two drugs and releases them at different times, dramatically shrinks lung and breast tumors. The MIT team, led by Michael Yaffe, the David H Continue reading

A hydrogel that knows when to go

A hydrogel that knows when to go

Rice University bioengineers have created a hydrogel that instantly turns from liquid to semisolid at close to body temperature — and then degrades at precisely the right pace. The gel shows potential as a bioscaffold to support the regrowth of bone and other three-dimensional tissues in a patient’s body using the patient’s own cells to seed the process Continue reading

A hydrogel that knows when to go

A hydrogel that knows when to go

Rice University bioengineers have created a hydrogel that instantly turns from liquid to semisolid at close to body temperature — and then degrades at precisely the right pace. The gel shows potential as a bioscaffold to support the regrowth of bone and other three-dimensional tissues in a patient’s body using the patient’s own cells to seed the process. Continue reading

Clinicians may be driving racial disparities in health, review finds

Clinicians may be driving racial disparities in health, review finds

Patients from minority ethnic groups in the US may be facing racist attitudes and beliefs that can unintentionally affect their treatment, a review of healthcare providers has found. The world’s first review explored interpersonal racism perpetrated by healthcare providers, a key driver of racial disparities in health Continue reading

Dementia diagnosis twice as likely if older adult has schizophrenia; Cancer less likely

Dementia diagnosis twice as likely if older adult has schizophrenia; Cancer less likely

Researchers from Regenstrief Institute and Indiana University who followed over 30,000 older adults for a decade have found the rate of dementia diagnosis for patients with schizophrenia to be twice as high as for patients without this chronic, severe and disabling brain disorder. Continue reading

New source of fat tissue stem cells discovered

New source of fat tissue stem cells discovered

Researchers have found a new source of stem cells that produce fat tissue, findings presented today at the European Congress of Endocrinology in Wrocław, Poland, show.  This unique in vitro human stem cell model of brown fat tissue could aid studies into how fat tissue develops and the development of new anti-obesity drugs. There are two types of fat tissue found in humans: white adipose tissue (WAT) that accumulates lipids, and brown adipose tissue (BAT) that can burn lipids to produce heat.  BAT is mainly found in babies, although recent studies show that adults may retain a small amount of BAT.  BAT is considered important in obesity research as it represents a potential pathway by which the body can control metabolism by burning excess lipids to produce heat.  Previously there have been no in vitro human models to aid research into BAT tissue development Continue reading

Novel analyses improve identification of cancer-associated genes from microarray data

Novel analyses improve identification of cancer-associated genes from microarray data

Dartmouth Institute for Quantitative Biomedical Sciences (iQBS) researchers developed a new gene expression analysis approach for identifying cancer genes. The paper entitled, “How to get the most from microarray data: advice from reverse genomics,” was published online March 21, 2014 in BMC Genomics . Continue reading

Promising biomarkers to predict suicide risk

Promising biomarkers to predict suicide risk

In this Review, published to coincide with the launch of The Lancet Psychiatry journal, Professor Kees van Heeringen from Ghent University in Belgium and John Mann from Columbia University in the USA discuss the stress-diathesis theory of suicide, in which a predisposition or diathesis interacts with stressful life experiences and acute psychiatric illness to cause suicidal behavior. The theory explains why only a small minority of individuals are at risk of taking their own lives after exposure to such stressors. The authors discuss the causes of the diathesis, or predisposition, to suicidal behavior, which may include genetic effects and the long-term impact on the brain and behavior of early life adversity (eg, physical and sexual abuse) Continue reading

Promising biomarkers to predict suicide risk

Promising biomarkers to predict suicide risk

In this Review, published to coincide with the launch of The Lancet Psychiatry journal, Professor Kees van Heeringen from Ghent University in Belgium and John Mann from Columbia University in the USA discuss the stress-diathesis theory of suicide, in which a predisposition or diathesis interacts with stressful life experiences and acute psychiatric illness to cause suicidal behavior. The theory explains why only a small minority of individuals are at risk of taking their own lives after exposure to such stressors. The authors discuss the causes of the diathesis, or predisposition, to suicidal behavior, which may include genetic effects and the long-term impact on the brain and behavior of early life adversity (eg, physical and sexual abuse). Continue reading