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Tag Archives: Protein

Fighting malaria drug resistance: Scientists find new way

Fighting malaria drug resistance: Scientists find new way

An anti-malarial treatment that lost its status as the leading weapon against the deadly disease could be given a new lease of life, with new research indicating it simply needs to be administered differently. The findings could revive the use of the cheap anti-malarial drug chloroquine in treating and preventing the mosquito-bourne disease, which claims the lives of more than half a million people each year around the world. The parasite that causes malaria has developed resistance to chloroquine, but research carried out at the Australian National University (ANU) and Germany’s University of Heidelberg has shown that the parasite protein that causes resistance has an Achilles’ heel Continue reading

New method for analyzing proteins in tissue samples

New method for analyzing proteins in tissue samples

A new way of preparing patient tissue for analyses might soon become the new standard. Continue reading

Scaffolding protein promotes growth, metastases of epithelial ovarian cancer

Scaffolding protein promotes growth, metastases of epithelial ovarian cancer

Researchers from Fox Chase Cancer Center have shown that NEDD9, a scaffolding protein responsible for regulating signaling pathways in the cell, promotes the growth and spread of epithelial ovarian cancer. Previous studies have demonstrated the protein’s importance in tumor invasion and spread of some lymphomas and many solid tumor types, including melanoma, neuroblastoma, and breast cancer, but its role in gynecological cancers has been poorly understood Continue reading

Cancer researchers find key protein link

Cancer researchers find key protein link

A new understanding of proteins at the nexus of a cell’s decision to survive or die has implications for researchers who study cancer and age-related diseases, according to biophysicists at the Rice University-based Center for Theoretical Biological Physics (CTBP). Experiments and computer analysis of two key proteins revealed a previously unknown binding interface that could be addressed by medication. Results of the research appear this week in an open-source paper in the Proceedings of the National Academy of Sciences Continue reading

Cholesterol transporter structure decoded

Cholesterol transporter structure decoded

The word “cholesterol” is directly linked in most people’s minds with high-fat foods, worrying blood test results, and cardiovascular diseases. However, despite its bad reputation, cholesterol is essential to our wellbeing: It stabilizes cell membranes and is a raw material for the production of different hormones in the cell’s power plants — the mitochondria Continue reading

Cholesterol transporter structure decoded

Cholesterol transporter structure decoded

The word “cholesterol” is directly linked in most people’s minds with high-fat foods, worrying blood test results, and cardiovascular diseases. However, despite its bad reputation, cholesterol is essential to our wellbeing: It stabilizes cell membranes and is a raw material for the production of different hormones in the cell’s power plants — the mitochondria Continue reading

New nanoparticle that only attacks cervical cancer cells

New nanoparticle that only attacks cervical cancer cells

One of the most promising technologies for the treatment of various cancers is nanotechnology, creating drugs that directly attack the cancer cells without damaging other tissues’ development. The Laboratory of Cellular Oncology at the Research Unit in Cell Differentiation and Cancer, of the Faculty of Higher Studies (FES) Zaragoza UNAM (National Autonomous University of Mexico) developed a therapy to attack cervical cancer tumors. Continue reading

New ovarian cancer targets proposed: Proteins called TAFs

New ovarian cancer targets proposed: Proteins called TAFs

In the complex genomic and molecular conspiracy that gives rise to ovarian cancer, what if researchers have been missing a whole set of suspects because they’ve been hiding in plain sight? That’s the argument made by Brown University biologists in a new paper that combines evidence from original research and prior studies to raise new suspicions about a set of proteins that assist in regulating gene expression. Scientists need such new leads in their investigation of ovarian cancer, the most deadly reproductive cancer Continue reading

Heat Shock Proteins May Shed New Light on a Variety of Debilitating Diseases

Heat Shock Proteins May Shed New Light on a Variety of Debilitating Diseases

Jan. 28, 2013 — UCLA researchers, in a finding that runs counter to conventional wisdom, have discovered for the first time that a gene thought to express a protein in all cells that come under stress is instead expressed only in specific cell types Continue reading

Enzyme helps cancer cells avoid genetic instability

Enzyme helps cancer cells avoid genetic instability

Jan. 21, 2013 — Cancer cells are resourceful survivors with plenty of tricks for staying alive. Researchers have uncovered one of these stratagems, showing how cells lacking the tumor suppressor BRCA1 can resume one form of DNA repair, sparing themselves from stagnation or death. Continue reading