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Tag Archives: Protein

Finding safe drugs to treat neurodegenerative diseases

Finding safe drugs to treat neurodegenerative diseases

People diagnosed with Huntington’s disease, most in their mid-thirties and forties, face a devastating prognosis: complete mental, physical, and behavioral decline within two decades. “Mutant” protein clusters, long blamed for the progression of the genetic disease, have been the primary focus of therapies in development by pharmaceutical companies Continue reading

Novel function of protein linked to Alzheimer’s disease discovered

Novel function of protein linked to Alzheimer’s disease discovered

A research team led by the National Neuroscience Institute (NNI) has uncovered a novel function of the Amyloid Precursor Protein (APP), one of the main pathogenic culprits of Alzheimer’s disease. This discovery may help researchers understand how the protein goes awry in the brains of Alzheimer’s disease patients, and potentially paves the way for the development of innovative therapeutics to improve the brain function of dementia patients. The findings were published in the scientific research journal Nature Communications last month Continue reading

Proteins conspire to make breast cancer cells resistant to drug treatment

Proteins conspire to make breast cancer cells resistant to drug treatment

Scientists at Sanford-Burnham Medical Research Institute (Sanford-Burnham) provide compelling and conclusive evidence that antiestrogen resistance in breast cancer cells requires the interaction between proteins called BCAR1 and BCAR3. In the study, published in the Journal of Biological Chemistry , the researchers also identified a signaling pathway that is crucial for drug resistance mediated by this protein complex Continue reading

Proteins conspire to make breast cancer cells resistant to drug treatment

Proteins conspire to make breast cancer cells resistant to drug treatment

Scientists at Sanford-Burnham Medical Research Institute (Sanford-Burnham) provide compelling and conclusive evidence that antiestrogen resistance in breast cancer cells requires the interaction between proteins called BCAR1 and BCAR3. In the study, published in the Journal of Biological Chemistry , the researchers also identified a signaling pathway that is crucial for drug resistance mediated by this protein complex Continue reading

Fighting malaria drug resistance: Scientists find new way

Fighting malaria drug resistance: Scientists find new way

An anti-malarial treatment that lost its status as the leading weapon against the deadly disease could be given a new lease of life, with new research indicating it simply needs to be administered differently. The findings could revive the use of the cheap anti-malarial drug chloroquine in treating and preventing the mosquito-bourne disease, which claims the lives of more than half a million people each year around the world. The parasite that causes malaria has developed resistance to chloroquine, but research carried out at the Australian National University (ANU) and Germany’s University of Heidelberg has shown that the parasite protein that causes resistance has an Achilles’ heel Continue reading

New method for analyzing proteins in tissue samples

New method for analyzing proteins in tissue samples

A new way of preparing patient tissue for analyses might soon become the new standard. Continue reading

Scaffolding protein promotes growth, metastases of epithelial ovarian cancer

Scaffolding protein promotes growth, metastases of epithelial ovarian cancer

Researchers from Fox Chase Cancer Center have shown that NEDD9, a scaffolding protein responsible for regulating signaling pathways in the cell, promotes the growth and spread of epithelial ovarian cancer. Previous studies have demonstrated the protein’s importance in tumor invasion and spread of some lymphomas and many solid tumor types, including melanoma, neuroblastoma, and breast cancer, but its role in gynecological cancers has been poorly understood Continue reading

Cancer researchers find key protein link

Cancer researchers find key protein link

A new understanding of proteins at the nexus of a cell’s decision to survive or die has implications for researchers who study cancer and age-related diseases, according to biophysicists at the Rice University-based Center for Theoretical Biological Physics (CTBP). Experiments and computer analysis of two key proteins revealed a previously unknown binding interface that could be addressed by medication. Results of the research appear this week in an open-source paper in the Proceedings of the National Academy of Sciences Continue reading

Cholesterol transporter structure decoded

Cholesterol transporter structure decoded

The word “cholesterol” is directly linked in most people’s minds with high-fat foods, worrying blood test results, and cardiovascular diseases. However, despite its bad reputation, cholesterol is essential to our wellbeing: It stabilizes cell membranes and is a raw material for the production of different hormones in the cell’s power plants — the mitochondria Continue reading

Cholesterol transporter structure decoded

Cholesterol transporter structure decoded

The word “cholesterol” is directly linked in most people’s minds with high-fat foods, worrying blood test results, and cardiovascular diseases. However, despite its bad reputation, cholesterol is essential to our wellbeing: It stabilizes cell membranes and is a raw material for the production of different hormones in the cell’s power plants — the mitochondria Continue reading