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Tag Archives: Research

Described novel regulator of protein inactive in over 50 percent of human tumors

Described novel regulator of protein inactive in over 50 percent of human tumors

Researchers at the Bellvitge Biomedical Research Institute (IDIBELL) and the University of Barcelona have discovered the interaction between HERC2 proteins with another protein called p53 that is inactivated in more than half of human tumors. The study results were published in the Journal of Biological Chemistry. Regulation of the activity of p53 by HERC2 The team of José Luis Rosa, at the growth factors and cell differentiation research group at IDIBELL studies the molecular mechanisms of HERC family proteins. Continue reading

Diagnostic criteria for Christianson Syndrome

Diagnostic criteria for Christianson Syndrome

Because the severe autism-like condition Christianson Syndrome was only first reported in 1999 and some symptoms take more than a decade to appear, families and doctors urgently need fundamental information about it. Continue reading

Diagnostic criteria for Christianson Syndrome

Diagnostic criteria for Christianson Syndrome

Because the severe autism-like condition Christianson Syndrome was only first reported in 1999 and some symptoms take more than a decade to appear, families and doctors urgently need fundamental information about it. Continue reading

Scientists map one of most important proteins in life — and cancer

Scientists map one of most important proteins in life — and cancer

Scientists reveal the structure of one of the most important and complicated proteins in cell division — a fundamental process in life and the development of cancer — in research published in Nature . Continue reading

Offering option of initial HIV care at home increases use of antiretroviral therapy

Offering option of initial HIV care at home increases use of antiretroviral therapy

LSTM Researchers found that offering adults in Malawi optional home initiation of care following HIV self-testing resulted in a significant increase in the proportion of adults initiating antiretroviral therapy (ART) compared with standard HIV care. The results are part of a study that was funded by the Wellcome Trust and published in the July 23/30 issue of JAMA , which is HIV/AIDS themed and released early to coincide with the International AIDS Conference taking place in Melbourne, Australia next week. In 2012 it was estimated that 35 million people worldwide were living with the human immunodeficiency virus (HIV). Continue reading

Targets for immunotherapy in early-stage breast cancer

Targets for immunotherapy in early-stage breast cancer

Yale Cancer Center researchers used a new molecular analysis tool to accurately detect the level of an important target for immunotherapy in early-stage breast cancers. The diagnostic test, using RNAScope, measures the amount of PD-L1 (programmed death ligand 1) mRNA in routine formalin-fixed cancer tissues and is devoid of many of the technical issues that plague antibody-based detection methods that have yielded conflicting results in the past. PD-L1 is the target of several novel immune stimulatory therapies in clinical trials Continue reading

Causes of death shifting in people with HIV

Causes of death shifting in people with HIV

HIV-positive adults in high income countries face a substantially reduced risk of death from AIDS-related causes, cardiovascular disease, and liver disease compared with a decade ago, according to a large international study published in The Lancet. The study which involved nearly 50,000 HIV-positive adults receiving care and antiretroviral therapy (ART) at more than 200 clinics across Europe, USA, and Australia found that overall death rates have almost halved since 1999, while deaths due to AIDS-related causes and cardiovascular disease have declined by around 65% and liver-related deaths by more than 50%. Although deaths from most causes declined over the study period, there was no reduction in death rates from non-AIDS cancers which remained stable over time (1.6 deaths per 1000 years 1999-2000 to 2.1 in 2009-2011) Continue reading

Adding alcohol to energy drinks leads to an increased urge to drink

Adding alcohol to energy drinks leads to an increased urge to drink

Public health advocates in recent years have become concerned not with the consumption of energy drinks by youth but also their joint consumption with alcohol by young adults. New research provides evidence of a mechanism through which energy drinks may increase binge drinking: combining energy drinks with alcohol increases people’s desire to keep drinking more than if they drank alcohol alone. Results will be published in the August 2014 online-only issue of Alcoholism: Clinical & Experimental Research and are currently available at Early View. Continue reading

Eating lean beef daily can help lower blood pressure, study suggests

Eating lean beef daily can help lower blood pressure, study suggests

Contrary to conventional wisdom, a growing body of evidence shows that eating lean beef can reduce risk factors for heart disease, according to recent research by nutritional scientists. “This research adds to the significant evidence, including work previously done in our lab, that supports lean beef’s role in a heart-healthy diet,” said Penny M. Kris-Etherton, Distinguished Professor of Nutrition, Penn State. Continue reading

Transplanting gene into injured hearts creates biological pacemakers

Transplanting gene into injured hearts creates biological pacemakers

Cardiologists at the Cedars-Sinai Heart Institute have developed a minimally invasive gene transplant procedure that changes unspecialized heart cells into “biological pacemaker” cells that keep the heart steadily beating. The laboratory animal research, published online and in today’s print edition of the peer-reviewed journal Science Translational Medicine , is the result of a dozen years of research with the goal of developing biological treatments for patients with heart rhythm disorders who currently are treated with surgically implanted pacemakers. Continue reading