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Tag Archives: Scientists

Ability to isolate, grow breast tissue stem cells could speed cancer research

Ability to isolate, grow breast tissue stem cells could speed cancer research

By carefully controlling the levels of two proteins, researchers at the Salk Institute have discovered how to keep mammary stem cells — those that can form breast tissue — alive and functioning in the lab. Continue reading

Ability to isolate, grow breast tissue stem cells could speed cancer research

Ability to isolate, grow breast tissue stem cells could speed cancer research

By carefully controlling the levels of two proteins, researchers at the Salk Institute have discovered how to keep mammary stem cells — those that can form breast tissue — alive and functioning in the lab. Continue reading

Autoimmune diseases may succumb to new drug strategy

Autoimmune diseases may succumb to new drug strategy

New pharmaceuticals to fight autoimmune diseases, such as multiple sclerosis, rheumatoid arthritis and psoriasis, may be identified more effectively by adding genome analysis to standard drug screening, according to a new study by a research team led by UC San Francisco and Harvard researchers, in collaboration with Tempero and GlaxoSmithKlein. Continue reading

New insights into bacterial substitute for sex

New insights into bacterial substitute for sex

Bacteria don’t have sex as such, but they can mix their genetic material by pulling in DNA from dead bacterial cells and inserting these into their own genome. New research led by Imperial College London has found that this process — called recombination — is more complex than was first thought. The findings, published today in PLoS Genetics , could help us understand why bacteria which cause serious diseases are able to evade vaccines and rapidly become drug-resistant. Continue reading

Stem cells from some infertile men form germ cells when transplanted into mice

Stem cells from some infertile men form germ cells when transplanted into mice

Stem cells made from the skin of adult, infertile men yield primordial germ cells — cells that normally become sperm — when transplanted into the reproductive system of mice, according to researchers at the Stanford University School of Medicine and Montana State University. The infertile men in the study each had a type of genetic mutation that prevented them from making mature sperm — a condition called azoospermia. The research suggests that the men with azoospermia may have had germ cells at some point in their early lives, but lost them as they matured to adulthood Continue reading

Novel regulator of key gene expression in cancer identified

Novel regulator of key gene expression in cancer identified

Scientists at the Salk Institute for Biological Studies have identified a key genetic switch linked to the development, progression and outcome of cancer, a finding that may lead to new targets for cancer therapies. Continue reading

Fattening gene discovered by researchers

Fattening gene discovered by researchers

The long-term consumption of too much high-energy and high-fat food leads to overweight. Continue reading

Low-dose natural antimicrobial exacerbates chronic lung infection in cystic fibrosis

Low-dose natural antimicrobial exacerbates chronic lung infection in cystic fibrosis

Respiratory failure caused by chronic lung infection with Pseudomonas aeruginosa bacteria is a common cause of death in patients with cystic fibrosis (CF), a genetic disease that is common in individuals of European descent. A study published on April 24th in PLOS Pathogens demonstrates that an antimicrobial peptide produced by human immune cells can promote mutations in the bacterium that make it more lethal. Continue reading

New type of protein action found to regulate development

New type of protein action found to regulate development

Johns Hopkins researchers report they have figured out how the aptly named protein Botch blocks the signaling protein called Notch, which helps regulate development. In a report on the discovery, to appear online April 24 in the journal Cell Reports , the scientists say they expect the work to lead to a better understanding of how a single protein, Notch, directs actions needed for the healthy development of organs as diverse as brains and kidneys Continue reading

New type of protein action found to regulate development

New type of protein action found to regulate development

Johns Hopkins researchers report they have figured out how the aptly named protein Botch blocks the signaling protein called Notch, which helps regulate development. In a report on the discovery, to appear online April 24 in the journal Cell Reports , the scientists say they expect the work to lead to a better understanding of how a single protein, Notch, directs actions needed for the healthy development of organs as diverse as brains and kidneys Continue reading