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Investigating ‘underground’ habitat of Listeria bacteria

Investigating ‘underground’ habitat of Listeria bacteria

The literature describes Listeria as ubiquitous bacteria with widespread occurrence. Yet they only become a problem for humans and animals when they contaminate food processing facilities, multiply, and enter the food chain in high concentrations. An infection with Listeria monocytogenes can even be fatal for humans or animals with weakened immune systems. Continue reading

Early sign of pancreatic cancer identified by researchers

Early sign of pancreatic cancer identified by researchers

Scientists at Dana-Farber Cancer Institute, the Massachusetts Institute of Technology, and other institutions have discovered a sign of the early development of pancreatic cancer – an upsurge in certain amino acids that occurs before the disease is diagnosed and symptoms appear. The research is being published online today by the journal Nature Medicine . Although the increase isn’t large enough to be the basis of a new test for early detection of the disease, the findings will help researchers better understand how pancreatic cancer affects the rest of the body, particularly how it can trigger the sometimes deadly muscle-wasting disease known as cachexia. Continue reading

Adding cediranib to chemotherapy improves progression-free survival for metastatic or recurrent cervical cancer, phase II trial shows

Adding cediranib to chemotherapy improves progression-free survival for metastatic or recurrent cervical cancer, phase II trial shows

For patients with cervical cancer that has recurred after treatment or has spread elsewhere in the body, adding the experimental drug cediranib to standard chemotherapy improves tumour shrinkage and adds a modest improvement in progression-free survival, researchers report at the ESMO 2014 Congress in Madrid. In Europe, about 70% of patients with cervical cancer are cured by either surgery or chemo-radiotherapy. Continue reading

Crizotinib treatment effective against ROS1-positive lung cancer, study suggests

Crizotinib treatment effective against ROS1-positive lung cancer, study suggests

Treatment with the targeted therapy drug crizotinib effectively halts the growth of lung tumors driven by rearrangements of the ROS1 gene. In an article receiving Online First publication in the New England Journal of Medicine to coincide with a presentation at the European Society for Medical Oncology meeting, an international research team reports that crizotinib treatment led to significant tumor shrinkage in 36 of 50 study participants and suppressed tumor growth in another 9 Continue reading

Chemotherapy: Rolapitant reduces nausea and vomiting in phase III trial

Chemotherapy: Rolapitant reduces nausea and vomiting in phase III trial

Rolapitant reduces nausea and vomiting in patients receiving cisplatin-based chemotherapy, according to the results of a phase III trial presented for the first time today at the ESMO 2014 Congress in Madrid, Spain. Dr Martin Chasen, lead author and medical director, Palliative Care, Ottawa Hospital Cancer Centre, Canada, said: “This agent makes a significant difference in the way people tolerate their chemotherapy. Patients experienced no loss in quality of life and, in fact, many saw meaningful improvements Continue reading

Countries must work together to stop organ traffickers, says researcher

Countries must work together to stop organ traffickers, says researcher

The author of new research into organ trafficking has called for a concerted international effort to confront the problem. Continue reading

Policies of NIH, other funders, have improved data-sharing by life-science investigators

Policies of NIH, other funders, have improved data-sharing by life-science investigators

Policies put into place by major funding agencies like the National Institutes of Health (NIH), and to a lesser extent by scientific journals, appear to be meeting the goal of increasing the sharing of scientific resources among life science investigators. As reported in the open-access journal PLOS ONE , 65 percent of surveyed investigators at major U.S. research institutions believed that NIH policies instituted in recent years had markedly improved the sharing of scientific data Continue reading

Policies of NIH, other funders, have improved data-sharing by life-science investigators

Policies of NIH, other funders, have improved data-sharing by life-science investigators

Policies put into place by major funding agencies like the National Institutes of Health (NIH), and to a lesser extent by scientific journals, appear to be meeting the goal of increasing the sharing of scientific resources among life science investigators. As reported in the open-access journal PLOS ONE , 65 percent of surveyed investigators at major U.S Continue reading

Child maltreatment underreported in medicaid claims, study finds

Child maltreatment underreported in medicaid claims, study finds

Medicaid claims are a poor way to identify child abuse and neglect at a population level, according to a study from the Brown School at Washington University in St. Louis. Lead author Ramesh Raghavan, PhD, associate professor at the Brown School and of psychiatry at the School of Medicine, examined Medicaid records from 36 states for 1,921 children in the National Survey of Child and Adolescent Well-Being, whom caseworkers had identified as having been maltreated, and who had received Medicaid-funded services. Continue reading

Many Patients Excluded From Lung Cancer Clinical Trials Due to Prior Cancer, Study Finds

Many Patients Excluded From Lung Cancer Clinical Trials Due to Prior Cancer, Study Finds

Lung cancer clinical trials exclude a substantial proportion of patients due to a history of prior cancer, as shown in an analysis by cancer researchers at UT Southwestern Medical Center. Among more than 50 lung cancer clinical trials examined, more than 80 percent excluded patients with prior cancer from participating, according to the study published in the Journal of the National Cancer Institute Continue reading