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Chemists recruit anthrax to deliver cancer drugs

Chemists recruit anthrax to deliver cancer drugs

Bacillus anthracis bacteria have very efficient machinery for injecting toxic proteins into cells, leading to the potentially deadly infection known as anthrax. A team of MIT researchers has now hijacked that delivery system for a different purpose: administering cancer drugs. “Anthrax toxin is a professional at delivering large enzymes into cells,” says Bradley Pentelute, the Pfizer-Laubauch Career Development Assistant Professor of Chemistry at MIT. Continue reading

Autoimmune diseases, chronic inflammations: Advancing research

Autoimmune diseases, chronic inflammations: Advancing research

The immune system functions as the body’s police force, protecting it from intruders like bacteria and viruses. However, in order to ascertain what is happening in the cell it requires information on the foreign invaders Continue reading

Autoimmune diseases, chronic inflammations: Advancing research

Autoimmune diseases, chronic inflammations: Advancing research

The immune system functions as the body’s police force, protecting it from intruders like bacteria and viruses. However, in order to ascertain what is happening in the cell it requires information on the foreign invaders Continue reading

Autoimmune diseases, chronic inflammations: Advancing research

Autoimmune diseases, chronic inflammations: Advancing research

The immune system functions as the body’s police force, protecting it from intruders like bacteria and viruses. However, in order to ascertain what is happening in the cell it requires information on the foreign invaders. This task is assumed by so-called immunoproteasomes Continue reading

Simple blood test could be used as tool for early cancer diagnosis

Simple blood test could be used as tool for early cancer diagnosis

Hypercalcaemia is the most common metabolic disorder associated with cancer, occurring in 10 to 20 per cent of people with cancer. While its connection to cancer is well known, this study has, for the first time, shown that often it can predate the diagnosis of cancer in primary care. Continue reading

Massive weight loss increases risk of complications in body-shaping surgery

Massive weight loss increases risk of complications in body-shaping surgery

Patients who lost more than 100 pounds and those who shed weight through bariatric surgery had the highest risk of complications from later surgical procedures to reshape their leaner bodies, a new study from UT Southwestern Medical Center shows. The study, published in the Aesthetic Surgery Journal , compared surgical complication outcomes for 450 patients who underwent body contouring, a type of surgery to remove excess sagging fat and skin to improve body shape. “This is one of the first large-scale studies comparing outcomes in patients losing significant amounts of weight via surgical and nonsurgical means,” said Dr. Continue reading

Massive weight loss increases risk of complications in body-shaping surgery

Massive weight loss increases risk of complications in body-shaping surgery

Patients who lost more than 100 pounds and those who shed weight through bariatric surgery had the highest risk of complications from later surgical procedures to reshape their leaner bodies, a new study from UT Southwestern Medical Center shows. The study, published in the Aesthetic Surgery Journal , compared surgical complication outcomes for 450 patients who underwent body contouring, a type of surgery to remove excess sagging fat and skin to improve body shape. “This is one of the first large-scale studies comparing outcomes in patients losing significant amounts of weight via surgical and nonsurgical means,” said Dr Continue reading

Dengue fever, malaria in the Himalayas

Dengue fever, malaria in the Himalayas

Research by Nepalese and German scientists from the Nepal Health Research Council, Goethe University and the LOEWE Biodiversity and Climate Research Centre analyzes the current situation of these diseases in the Himalayan country of Nepal and highlights how they profit from climate change and globalization. Dengue fever: high risk, little knowledge Although the first case of dengue fever in Nepal was only reported in 2004, the country was shaken by an epidemic already in 2010 Continue reading

Bacterial ‘communication system’ could be used to stop, kill cancer cells, study finds

Bacterial ‘communication system’ could be used to stop, kill cancer cells, study finds

Cancer, while always dangerous, truly becomes life-threatening when cancer cells begin to spread to different areas throughout the body. Now, researchers at the University of Missouri have discovered that a molecule used as a communication system by bacteria can be manipulated to prevent cancer cells from spreading. Senthil Kumar, an assistant research professor and assistant director of the Comparative Oncology and Epigenetics Laboratory at the MU College of Veterinary Medicine, says this communication system can be used to “tell” cancer cells how to act, or even to die on command. Continue reading

A way to kill chemo-resistant ovarian cancer cells: Cut down its protector

A way to kill chemo-resistant ovarian cancer cells: Cut down its protector

Ovarian cancer is the most deadly gynecological cancer, claiming the lives of more than 50% of women who are diagnosed with the disease. A study involving Ottawa and Taiwan researchers, published in the journal Proceedings of the National Academy of Sciences (PNAS) , provides new insight into why ovarian cancer is often resistant to chemotherapy, as well as a potential way to improve its diagnosis and treatment. It is estimated that 2,700 Canadian women will be diagnosed with ovarian cancer in 2014 and that 1,750 Canadian women will die from the disease, according to Ovarian Cancer Canada. Continue reading