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Effective treatments available for HIV patients not eligible for efavirenz regimens

Effective treatments available for HIV patients not eligible for efavirenz regimens

A new national clinical trial found HIV drug regimens that do not include efavirenz are effective as first-line antiretroviral therapy. Continue reading

Vesicles influence function of nerve cells

Vesicles influence function of nerve cells

Date: October 6, 2014 Source: Universität Mainz Summary: Tiny vesicles containing protective substances that they transmit to nerve cells apparently play an important role in the functioning of neurons. As cell biologists have discovered, nerve cells can enlist the aid of mini-vesicles of neighboring glial cells to defend themselves against stress and other potentially detrimental factors. Continue reading

Cell migration: How it works, how new discovery may inform cancer research

Cell migration: How it works, how new discovery may inform cancer research

During cancer metastasis, immune response cells are moving in a controlled manner through the body. Researchers from the Department of Biomedicine at the University of Basel discovered novel mechanisms of cell migration by observing cells moving on lines of connective tissue. Their results, published in the journal Developmental Cell, could lead to new approaches in combatting cancer metastasis and inflammation Continue reading

Tumors might grow faster at night

Tumors might grow faster at night

They emerge at night, while we sleep unaware, growing and spreading out as quickly as they can. And they are deadly. Continue reading

Vicious cycle in osteoarthritis: Sleep disturbance, pain, depression, disability

Vicious cycle in osteoarthritis: Sleep disturbance, pain, depression, disability

New research confirms that sleep disturbances are linked to pain and depression, but not disability, among patients with osteoarthritis (OA). Continue reading

First pictures of BRCA2 protein show how it works to repair DNA

First pictures of BRCA2 protein show how it works to repair DNA

Scientists have taken pictures of the BRCA2 protein for the first time, showing how it works to repair damaged DNA. Mutations in the gene that encodes BRCA2 are well known for raising the risk of breast cancer and other cancers. Although the protein was known to be involved in DNA repair, its shape and mechanism have been unclear, making it impossible to target with therapies Continue reading

Attacking type 2 diabetes from a new direction with encouraging results

Attacking type 2 diabetes from a new direction with encouraging results

Type 2 diabetes affects an estimated 28 million Americans according to the American Diabetes Association, but medications now available only treat symptoms, not the root cause of the disease. New research from Rutgers shows promising evidence that a modified form of a different drug, niclosamide — now used to eliminate intestinal parasites — may hold the key to battling the disease at its source. The study, led by Victor Shengkan Jin, an associate professor of pharmacology at Rutgers Robert Wood Johnson Medical School, has been published online by the journal Nature Medicine Continue reading

Discovery of a novel heart, gut disease

Discovery of a novel heart, gut disease

Physicians and researchers at CHU Sainte-Justine, Université de Montréal, CHU de Québec, Université Laval, and Hubrecht Institute have discovered a rare disease affecting both heart rate and intestinal movements. Continue reading

Implications of ipsilateral spatial neglect after stroke explored by stroke researchers

Implications of ipsilateral spatial neglect after stroke explored by stroke researchers

Stroke researchers have confirmed that damage to the right frontal-subcortical network may cause ipsilateral spatial neglect. Among individuals with ipsilateral neglect, a much greater proportion had frontal subcortical damage than anticipated by the investigators — 83% vs the expected 27%. Continue reading

Pain words stand out more for those experiencing it

Pain words stand out more for those experiencing it

Ache, agony, distress and pain draw more attention than non-pain related words when it comes to people who suffer from chronic pain, a York University research using state-of-the-art eye-tracking technology has found. “People suffering from chronic pain pay more frequent and longer attention to pain-related words than individuals who are pain-free,” says Samantha Fashler, a PhD candidate in the Faculty of Health and the lead author of the study Continue reading