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New human trial shows stem cells are effective for failing hearts: Bone marrow-derived stem cells injected directly into heart muscle

New human trial shows stem cells are effective for failing hearts: Bone marrow-derived stem cells injected directly into heart muscle

Patients with severe ischemic heart disease and heart failure can benefit from a new treatment in which stem cells found in bone marrow are injected directly into the heart muscle, according to research presented at the American College of Cardiology’s 63rd Annual Scientific Session. “Our results show that this stem cell treatment is safe and it improves heart function when compared to placebo,” said Anders Bruun Mathiasen, M.D., research fellow in the Cardiac Catherization Lab at Rigshospitalet University Hospital Copenhagen, and lead investigator of the study. “This represents an exciting development that has the potential to benefit many people who suffer from this common and deadly disease.” Ischemic heart disease, also known as coronary artery disease, is the number one cause of death for both men and women in the United States Continue reading

Real-world heart procedure results consistent with scientific research

Real-world heart procedure results consistent with scientific research

The first one-year outcomes data of transcatheter heart valve replacement (TAVR) in nearly all U.S. Continue reading

Genetic cause of heart valve defects revealed

Genetic cause of heart valve defects revealed

Heart valve defects are a common cause of death in newborns. Scientists at the University of Bonn and the caesar research center have discovered “Creld1″ is a key gene for the development of heart valves in mice Continue reading

Cardiac resynchronization improves survival in heart failure patients

Cardiac resynchronization improves survival in heart failure patients

Patients in mild heart failure who receive a specialized pacemaker known as cardiac resynchronization therapy with a defibrillator (CRT-D) may live longer than those implanted with a traditional implantable cardioverter defibrillator (ICD), according to research presented at the American College of Cardiology’s 63rd Annual Scientific Session. In the first study to look at CRT-D in mildly symptomatic patients, researchers found that patients with left bundle branch block implanted with a CRT-D had a 41 percent reduced risk of death compared to patients who had a conventional ICD Continue reading

Renal denervation patient registry finds low rate of adverse events

Renal denervation patient registry finds low rate of adverse events

Patients with uncontrolled high blood pressure treated with renal denervation had low rates of adverse events and significant lowering of blood pressure at six months, according to a registry-based study presented at the American College of Cardiology’s 63rd Annual Scientific Session. The Global SYMPLICITY Registry is the first and largest dataset of patients with uncontrolled hypertension treated with renal denervation. The open-label, multicenter study was established to examine the safety and effectiveness of the procedure. Continue reading

Evolocumab safely drops LDL cholesterol well below statin-only baseline, study suggests

Evolocumab safely drops LDL cholesterol well below statin-only baseline, study suggests

The monoclonal antibody evolocumab produced highly significant reductions in low-density lipoprotein (LDL) cholesterol, the “bad cholesterol,” as an add-on to statins in all treatment groups, according to data from the LAPLACE-2 study presented at the American College of Cardiology’s 63rd Annual Scientific Session. LDL cholesterol is considered a major risk factor for cardiovascular disease. “High-risk patients — such as those with clinical cardiovascular disease, high LDL cholesterol levels or diabetes — are ideally treated with high-intensity statins that lower LDL cholesterol by at least 50 percent, but that isn’t always possible,” said Jennifer G. Continue reading

Adults with inherited high cholesterol underdiagnosed, undertreated

Adults with inherited high cholesterol underdiagnosed, undertreated

An estimated 1 in 500 people worldwide suffer from familial hypercholesterolaemia (FH), an inherited condition of extremely high cholesterol that is associated with premature heart disease and death. Despite this high prevalence, recent research funded by the Minneapolis Heart Institute Foundation (MHIF) confirms FH is underdiagnosed and undertreated. Thomas Knickelbine, MD, Preventive Cardiology Director at the Minneapolis Heart Institute at Abbott Northwestern Hospital, will present the results of research aimed at identifying just how prevalent FH underdiagnosis is at the American College of Cardiology (ACC) meeting in Washington, DC on March 30 Continue reading

Anesthetic technique important to prevent damage to brain

Anesthetic technique important to prevent damage to brain

Researchers at the University of Adelaide have discovered that a commonly used anesthetic technique to reduce the blood pressure of patients undergoing surgery could increase the risk of starving the brain of oxygen. Continue reading

Bariatric surgery provides long-term control of diabetes

Bariatric surgery provides long-term control of diabetes

A study by Cleveland Clinic researchers shows bariatric surgery is a highly effective and durable treatment for type 2 diabetes in obese patients, enabling nearly all surgical patients to be free of insulin and many to be free of all diabetic medications three years after surgery. The STAMPEDE (Surgical Therapy And Medications Potentially Eradicate Diabetes Efficiently) trial was simultaneously published in the New England Journal of Medicine and presented today at the Annual Scientific Session of the American College of Cardiology in Washington, D.C. The study also shows that bariatric surgery patients experienced an improvement in quality of life and a reduction in the need for cardiovascular medications to control blood pressure and cholesterol compared to those receiving medical therapy. Continue reading

Brawn matters: Stronger adolescents, teens have less risk of diabetes, heart disease

Brawn matters: Stronger adolescents, teens have less risk of diabetes, heart disease

Adolescents with stronger muscles have a lower risk of heart disease and diabetes, according to a new study that examined the influence of muscle strength in sixth grade boys and girls. Continue reading