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New biomarker highly promising for predicting breast cancer outcomes

New biomarker highly promising for predicting breast cancer outcomes

A protein named p66ShcA shows promise as a biomarker to identify breast cancers with poor prognoses, according to research published ahead of print in the journal Molecular and Cellular Biology . Continue reading

Two case reports of rare stiff person syndrome

Two case reports of rare stiff person syndrome

Two female patients achieved clinical remission from the rare, debilitating neurological disease called stiff person syndrome (SPS, which can be marked by a “tin soldier” gait) after an autologous (from your own body) stem cell transplant that eventually allowed them to return to work and regain their previous functioning. SPS is a disease characterized by stiffness of the skeletal muscles, painful muscle spasms and, in severe cases, the disease can prevent movement and walking. Autologous hematopoietic stem cell transplantation (auto-HSCT) has been used to successfully treat patients with autoimmune diseases such as multiple sclerosis and scleroderma, which are resistant to more conventional treatment. Continue reading

Complication risk of deep brain stimulation similar for older, younger Parkinson patients

Complication risk of deep brain stimulation similar for older, younger Parkinson patients

Older patients with Parkinson disease (PD) who undergo deep brain stimulation (DBS) appear to have a 90-day complication risk similar to younger patients, suggesting that age alone should not be a primary factor for excluding patients as DBS candidates. Continue reading

Weekend hospitalization linked to longer stay for pediatric leukemia patients

Weekend hospitalization linked to longer stay for pediatric leukemia patients

Weekend admission to the hospital for pediatric patients newly diagnosed with leukemia was associated with a longer length of stay, slightly longer wait to start chemotherapy and higher risk for respiratory failure but weekend admissions were not linked to an increased risk for death. Leukemia is a common childhood cancer that accounts for about 30 percent of all pediatric cancer diagnoses. Previous research has indicated an increased risk of death in adults with leukemia whose first admission was on a weekend Continue reading

Aspirin may reduce the risks of reoccurring blood clots

Aspirin may reduce the risks of reoccurring blood clots

Aspirin may be a promising alternative for those who can’t take long-term anticoagulant drugs that prevent clots from reoccurring in the veins, according to new research in the American Heart Association journal Circulation. In a combined analysis of two similar independent studies, 1,224 patients who received 100 mg of aspirin a day to treat blood clots were monitored for at least two years. Continue reading

Finding keys to glioblastoma therapeutic resistance

Finding keys to glioblastoma therapeutic resistance

Researchers at the University of California, San Diego School of Medicine have found one of the keys to why certain glioblastomas — the primary form of a deadly brain cancer — are resistant to drug therapy. The answer lies not in the DNA sequence of the tumor, but in its epigenetic signature Continue reading

High concordance between EGFR mutations from circulating-free tumor DNA and tumor tissue in non-small cell lung cancer

High concordance between EGFR mutations from circulating-free tumor DNA and tumor tissue in non-small cell lung cancer

Epidermal growth factor receptor (EGFR) mutations found in the circulating free tumor DNA (ctDNA) from the plasma of advanced non-small cell lung cancer (NSCLC) patients correlates well with the EGFR mutations from patient-matched tumor tissue DNA. EGFR tyrosine kinase inhibitor (TKI) therapy is approved for EGFR activating mutation positive patients with advanced NSCLC, but the standard for determining mutation status is with DNA derived directly from tumor tissue, which can be limited or not available. A more abundant and less invasive source of tumor DNA may be cell free tumor DNA found circulating in the blood. Continue reading

Novel oncogenic RET mutation found in small cell lung cancer

Novel oncogenic RET mutation found in small cell lung cancer

For the first time an oncogenic somatic mutation at amino acid 918 in the RET (rearranged during transfection) protein has been identified in small cell lung cancer (SCLC) tumors and enforced expression of this mutation within SCLC cell lines produced increased intracellular signaling and cell growth. SCLC is a highly malignant form of lung cancer representing 15% of all lung cancers and is strongly associated with tobacco smoking Continue reading

Deletion predicts survival in advanced non-small cell lung cancer

Deletion predicts survival in advanced non-small cell lung cancer

Bcl-2-like protein 11 (BIM) deletion in advanced non-small cell lung cancer (NSCLC) is associated with shorter progression free survival (PFS) in epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) or chemotherapy treated Asian patients. Continue reading

Study of self-awareness in MS has implications for rehabilitation

Study of self-awareness in MS has implications for rehabilitation

A new study of self-awareness by Kessler Foundation researchers shows that persons with multiple sclerosis (MS) may be able to improve their self-awareness through task-oriented cognitive rehabilitation. The study was epublished ahead of print on July 2 in NeuroRehabilitation . Self-awareness is one’s ability to recognize cognitive problems caused by brain injury. Continue reading