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Cancer blood test moves step closer

Cancer blood test moves step closer

unable to retrieve full-text contentA British team of researchers has developed what might be a simple blood test for cancer, scientists from the University of Bradford say. Continue reading

Described novel regulator of protein inactive in over 50 percent of human tumors

Described novel regulator of protein inactive in over 50 percent of human tumors

Researchers at the Bellvitge Biomedical Research Institute (IDIBELL) and the University of Barcelona have discovered the interaction between HERC2 proteins with another protein called p53 that is inactivated in more than half of human tumors. The study results were published in the Journal of Biological Chemistry. Continue reading

Described novel regulator of protein inactive in over 50 percent of human tumors

Described novel regulator of protein inactive in over 50 percent of human tumors

Researchers at the Bellvitge Biomedical Research Institute (IDIBELL) and the University of Barcelona have discovered the interaction between HERC2 proteins with another protein called p53 that is inactivated in more than half of human tumors. The study results were published in the Journal of Biological Chemistry. Regulation of the activity of p53 by HERC2 The team of José Luis Rosa, at the growth factors and cell differentiation research group at IDIBELL studies the molecular mechanisms of HERC family proteins. Continue reading

Missing sleep may hurt your memory

Missing sleep may hurt your memory

Lack of sleep, already considered a public health epidemic, can also lead to errors in memory, finds a new study by researchers at Michigan State University and the University of California, Irvine. The study, published online in the journal Psychological Science , found participants deprived of a night’s sleep were more likely to flub the details of a simulated burglary they were shown in a series of images Continue reading

Metabolic enzyme stops progression of most common type of kidney cancer

Metabolic enzyme stops progression of most common type of kidney cancer

In an analysis of small molecules called metabolites used by the body to make fuel in normal and cancerous cells in human kidney tissue, a research team from the Perelman School of Medicine at the University of Pennsylvania identified an enzyme key to applying the brakes on tumor growth. Continue reading

Combination treatment for hep C associated with favorable response among HIV patients

Combination treatment for hep C associated with favorable response among HIV patients

HIV-infected patients also infected with hepatitis C virus (HCV) who received a combination of the medications sofosbuvir plus ribavirin had high rates of sustained HCV virologic response 12 weeks after cessation of therapy, according to a study in the July 23/30 issue of JAMA , a theme issue on HIV/AIDS. The issue is being released early to coincide with the International AIDS Conference Continue reading

New clues to brain’s wiring found by scientists

New clues to brain’s wiring found by scientists

New research provides an intriguing glimpse into the processes that establish connections between nerve cells in the brain. Continue reading

Targets for immunotherapy in early-stage breast cancer

Targets for immunotherapy in early-stage breast cancer

Yale Cancer Center researchers used a new molecular analysis tool to accurately detect the level of an important target for immunotherapy in early-stage breast cancers. The diagnostic test, using RNAScope, measures the amount of PD-L1 (programmed death ligand 1) mRNA in routine formalin-fixed cancer tissues and is devoid of many of the technical issues that plague antibody-based detection methods that have yielded conflicting results in the past. PD-L1 is the target of several novel immune stimulatory therapies in clinical trials Continue reading

Adults with eosinophilic esophagitis should consider a diet change

Adults with eosinophilic esophagitis should consider a diet change

Dietary elimination is a successful method of treatment for adults with eosinophilic esophagitis (EoE), according to a new study in Clinical Gastroenterology and Hepatology , the official clinical practice journal of the American Gastroenterological Association. Continue reading

Causes of death shifting in people with HIV

Causes of death shifting in people with HIV

HIV-positive adults in high income countries face a substantially reduced risk of death from AIDS-related causes, cardiovascular disease, and liver disease compared with a decade ago, according to a large international study published in The Lancet. The study which involved nearly 50,000 HIV-positive adults receiving care and antiretroviral therapy (ART) at more than 200 clinics across Europe, USA, and Australia found that overall death rates have almost halved since 1999, while deaths due to AIDS-related causes and cardiovascular disease have declined by around 65% and liver-related deaths by more than 50%. Although deaths from most causes declined over the study period, there was no reduction in death rates from non-AIDS cancers which remained stable over time (1.6 deaths per 1000 years 1999-2000 to 2.1 in 2009-2011) Continue reading