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Treating eye diseases with anti-VEGF therapies may have side effects

Treating eye diseases with anti-VEGF therapies may have side effects

Jan. 11, 2013 — A new Investigative Ophthalmology & Visual Science (IOVS) article reveals that increasingly aggressive therapies that block VEGF could cause damage in treating eye diseases Continue reading

Gene therapy reprograms scar tissue in damaged hearts into healthy heart muscle

Gene therapy reprograms scar tissue in damaged hearts into healthy heart muscle

Jan. 4, 2013 — A cocktail of three specific genes can reprogram cells in the scars caused by heart attacks into functioning muscle cells, and the addition of a gene that stimulates the growth of blood vessels enhances that effect, said researchers from Weill Cornell Medical College, Baylor College of Medicine and Stony Brook University Medical Center in a report that appears online in the Journal of the American Heart Association . Continue reading

Combination treatment may improve survival of breast cancer patients with brain metastases

Combination treatment may improve survival of breast cancer patients with brain metastases

ScienceDaily (Nov. 1, 2012) — Adding an angiogenesis inhibitor to treatment with a HER2-inhibiting drug could improve outcomes for patients with HER2-positive breast cancer who develop brain metastases Continue reading

Natural process activating brain’s immune cells could point way to repairing damaged brain tissue

Natural process activating brain’s immune cells could point way to repairing damaged brain tissue

ScienceDaily (Oct. 21, 2012) — The brain’s key “breeder” cells, it turns out, do more than that. They secrete substances that boost the numbers and strength of critical brain-based immune cells believed to play a vital role in brain health. Continue reading

Better treatment for brain cancer revealed by new molecular insights

Better treatment for brain cancer revealed by new molecular insights

ScienceDaily (July 9, 2012) — Nearly a third of adults with the most common type of brain cancer develop recurrent, invasive tumors after being treated with a drug called bevacizumab. Continue reading

An economical, effective and biocompatible gene therapy strategy promotes cardiac repair

An economical, effective and biocompatible gene therapy strategy promotes cardiac repair

ScienceDaily (July 6, 2012) — Dr Changfa Guo, Professor Chunsheng Wang and their co-investigators from Zhongshan hospital Fudan University, Shanghai, China have established a novel hyperbranched poly(amidoamine) (hPAMAM) nanoparticle based hypoxia regulated vascular endothelial growth factor (HRE-VEGF) gene therapy strategy which is an excellent substitute for the current expensive and uncontrollable VEGF gene delivery system. This discovery, reported in the June 2012 issue of Experimental Biology and Medicine , provides an economical, feasible and biocompatible gene therapy strategy for cardiac repair. Continue reading

New role of vascular endothelial growth factor in regulating skin cancer stem cells

New role of vascular endothelial growth factor in regulating skin cancer stem cells

ScienceDaily (Oct. 20, 2011) — One of the key questions in cancer is the identification of the mechanisms that regulate cancer stem cells and tumor growth. In a study published in Nature , researchers led by Cédric Blanpain, MD/PhD, FNRS/FRS researcher and WELBIO investigator at the IRIBHM, Université libre de Bruxelles, Belgium, in collaboration with the groups of Peter Carmeliet (VIB/K.U.Leuven) and Jody J Continue reading

Laying bare the not-so-sweet tale of a sugar and its role in the spread of cancer

Laying bare the not-so-sweet tale of a sugar and its role in the spread of cancer

ScienceDaily (Apr. Continue reading

Combining two peptide inhibitors might block tumor growth

Combining two peptide inhibitors might block tumor growth

ScienceDaily (Mar. 14, 2011) — A new study suggests that combining two experimental anticancer peptide agents might simultaneously block formation of new tumor blood vessels while also inhibiting the growth of tumor cells. This early test of the two agents in a breast cancer model suggests that the double hit can stifle tumor progression, avoid drug resistance and cause few side effects, say researchers at the Ohio State University Comprehensive Cancer Center — Arthur G. Continue reading

Combining two peptide inhibitors might block tumor growth

Combining two peptide inhibitors might block tumor growth

ScienceDaily (Mar. 14, 2011) — A new study suggests that combining two experimental anticancer peptide agents might simultaneously block formation of new tumor blood vessels while also inhibiting the growth of tumor cells. This early test of the two agents in a breast cancer model suggests that the double hit can stifle tumor progression, avoid drug resistance and cause few side effects, say researchers at the Ohio State University Comprehensive Cancer Center — Arthur G. Continue reading