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Tag Archives: Work

New type of protein action found to regulate development

New type of protein action found to regulate development

Johns Hopkins researchers report they have figured out how the aptly named protein Botch blocks the signaling protein called Notch, which helps regulate development. In a report on the discovery, to appear online April 24 in the journal Cell Reports , the scientists say they expect the work to lead to a better understanding of how a single protein, Notch, directs actions needed for the healthy development of organs as diverse as brains and kidneys Continue reading

New type of protein action found to regulate development

New type of protein action found to regulate development

Johns Hopkins researchers report they have figured out how the aptly named protein Botch blocks the signaling protein called Notch, which helps regulate development. In a report on the discovery, to appear online April 24 in the journal Cell Reports , the scientists say they expect the work to lead to a better understanding of how a single protein, Notch, directs actions needed for the healthy development of organs as diverse as brains and kidneys Continue reading

Not just the poor live hand-to-mouth

Not just the poor live hand-to-mouth

When the economy hits the skids, government stimulus checks to the poor sometimes follow. Stimulus programs — such as those in 2001, 2008 and 2009 — are designed to boost the economy quickly by getting cash into the hands of people likely to turn around and spend it. But sending cash to just the very poor may not be the right approach, according to researchers from Princeton University and New York University who analyzed information on the finances of U.S Continue reading

MRI, on a molecular scale: System could one day peer into the atomic structure of individual molecules

MRI, on a molecular scale: System could one day peer into the atomic structure of individual molecules

For decades, scientists have used techniques like X-ray crystallography and nuclear magnetic resonance imaging (NMR) to gain invaluable insight into the atomic structure of molecules, but such efforts have long been hampered by the fact that they demand large quantities of a specific molecule and often in ordered and crystalized form to be effective — making it all but impossible to peer into the structure of most molecules. Harvard researchers, however, say those problems may soon be a thing of the past. Continue reading

MRI, on a molecular scale: System could one day peer into the atomic structure of individual molecules

MRI, on a molecular scale: System could one day peer into the atomic structure of individual molecules

For decades, scientists have used techniques like X-ray crystallography and nuclear magnetic resonance imaging (NMR) to gain invaluable insight into the atomic structure of molecules, but such efforts have long been hampered by the fact that they demand large quantities of a specific molecule and often in ordered and crystalized form to be effective — making it all but impossible to peer into the structure of most molecules. Harvard researchers, however, say those problems may soon be a thing of the past. Continue reading

Eavesdropping on brain cell chatter

Eavesdropping on brain cell chatter

Everything we do — all of our movements, thoughts and feelings — are the result of neurons talking with one another, and recent studies have suggested that some of the conversations might not be all that private. Brain cells known as astrocytes may be listening in on, or even participating in, some of those discussions. Continue reading

Cancer drugs block dementia-linked brain inflammation, study finds

Cancer drugs block dementia-linked brain inflammation, study finds

A class of drugs developed to treat immune-related conditions and cancer — including one currently in clinical trials for glioblastoma and other tumors — eliminates neural inflammation associated with dementia-linked diseases and brain injuries, according to UC Irvine researchers. In their study, assistant professor of neurobiology & behavior Kim Green and colleagues discovered that the drugs, which can be delivered orally, eradicated microglia, the primary immune cells of the brain. These cells exacerbate many neural diseases, including Alzheimer’s and Parkinson’s, as well as brain injury Continue reading

Cancer drugs block dementia-linked brain inflammation, study finds

Cancer drugs block dementia-linked brain inflammation, study finds

A class of drugs developed to treat immune-related conditions and cancer — including one currently in clinical trials for glioblastoma and other tumors — eliminates neural inflammation associated with dementia-linked diseases and brain injuries, according to UC Irvine researchers. In their study, assistant professor of neurobiology & behavior Kim Green and colleagues discovered that the drugs, which can be delivered orally, eradicated microglia, the primary immune cells of the brain. These cells exacerbate many neural diseases, including Alzheimer’s and Parkinson’s, as well as brain injury. Continue reading

Researchers examine metabolism in defective cells

Researchers examine metabolism in defective cells

UAlberta researchers are taking a closer look at how two metabolic pathways interact to increase the lifespan of cells with mitochondrial defects. Magnus Friis (PhD ’10) is the lead author of the study, which was published online on April 10 and will be published in the April 24 issue of Cell Reports. Mitochondria produce energy for cells through oxidative metabolism, but the process produces toxic byproducts that can accumulate and cause defects in the cell’s mitochondria Continue reading

Protein researchers closing in on the mystery of schizophrenia

Protein researchers closing in on the mystery of schizophrenia

Schizophrenia is a severe disease for which there is still no effective medical treatment. In an attempt to understand exactly what happens in the brain of schizophrenic people, researchers from the University of Southern Denmark have analysed proteins in the brains of rats that have been given hallucinogenic drugs. This may pave the way for new and better medicines. Continue reading