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Tag Archives: Work

Designer ‘barrel’ proteins created

Designer ‘barrel’ proteins created

Proteins are long linear molecules that fold up to form well-defined 3D shapes. These 3D molecular architectures are essential for biological functions such as the elasticity of skin, the digestion of food, and the transport of oxygen in blood Continue reading

Designer ‘barrel’ proteins created

Designer ‘barrel’ proteins created

Proteins are long linear molecules that fold up to form well-defined 3D shapes. These 3D molecular architectures are essential for biological functions such as the elasticity of skin, the digestion of food, and the transport of oxygen in blood Continue reading

Real-time tracking system developed to monitor dangerous bacteria inside body

Real-time tracking system developed to monitor dangerous bacteria inside body

Combining a PET scanner with a new chemical tracer that selectively tags specific types of bacteria, Johns Hopkins researchers working with mice report they have devised a way to detect and monitor in real time infections with a class of dangerous Gram-negative bacteria. These increasingly drug-resistant bacteria are responsible for a range of diseases, including fatal pneumonias and various bloodstream or solid-organ infections acquired in and outside the hospital. “What we have produced is essentially a system that localizes the epicenter of infection and provides real-time tracking of bacterial activity, giving us rapid feedback on how the bacteria respond to antibiotics,” says principal investigator Sanjay Jain, M.D., an infectious disease specialist at the Johns Hopkins Children’s Center and director of the Center for Inflammation Imaging and Research at Johns Hopkins Continue reading

Mental rest and reflection boost learning, study suggests

Mental rest and reflection boost learning, study suggests

A new study, which may have implications for approaches to education, finds that brain mechanisms engaged when people allow their minds to rest and reflect on things they’ve learned before, may boost later learning. Continue reading

Mental rest and reflection boost learning, study suggests

Mental rest and reflection boost learning, study suggests

A new study, which may have implications for approaches to education, finds that brain mechanisms engaged when people allow their minds to rest and reflect on things they’ve learned before, may boost later learning. Scientists have already established that resting the mind, as in daydreaming, helps strengthen memories of events and retention of information. In a new twist, researchers at The University of Texas at Austin have shown that the right kind of mental rest, which strengthens and consolidates memories from recent learning tasks, helps boost future learning. Continue reading

Untangling the biological effects of blue light

Untangling the biological effects of blue light

Blue light can both set the mood and set in motion important biological responses. Researchers at the University of Pennsylvania’s School of Medicine and School of Arts and Sciences have teased apart the separate biological responses of the human eye to blue light, revealing an unexpected contest for control. Continue reading

Untangling the biological effects of blue light

Untangling the biological effects of blue light

Blue light can both set the mood and set in motion important biological responses. Researchers at the University of Pennsylvania’s School of Medicine and School of Arts and Sciences have teased apart the separate biological responses of the human eye to blue light, revealing an unexpected contest for control. Their work addresses the properties of melanopsin, a light-sensitive protein in the eye that establishes the rhythm of our day-night cycle and the familiar constriction of the pupil to bright light. Continue reading

Scientists restore hearing in noise-deafened mice, pointing way to new therapies

Scientists restore hearing in noise-deafened mice, pointing way to new therapies

Scientists have restored the hearing of mice partly deafened by noise, using advanced tools to boost the production of a key protein in their ears. By demonstrating the importance of the protein, called NT3, in maintaining communication between the ears and brain, these new findings pave the way for research in humans that could improve treatment of hearing loss caused by noise exposure and normal aging. In a new paper in the online journal eLife , the team from the University of Michigan Medical School’s Kresge Hearing Research Institute and Harvard University report the results of their work to understand NT3′s role in the inner ear, and the impact of increased NT3 production on hearing after a noise exposure. Continue reading

Scientists restore hearing in noise-deafened mice, pointing way to new therapies

Scientists restore hearing in noise-deafened mice, pointing way to new therapies

Scientists have restored the hearing of mice partly deafened by noise, using advanced tools to boost the production of a key protein in their ears. By demonstrating the importance of the protein, called NT3, in maintaining communication between the ears and brain, these new findings pave the way for research in humans that could improve treatment of hearing loss caused by noise exposure and normal aging Continue reading

Gene duplications associated with autism evolved recently in human history

Gene duplications associated with autism evolved recently in human history

Human geneticists have discovered that a region of the genome associated with autism contains genetic variation that evolved in the last 250,000 years, after the divergence of humans from ancient hominids, and likely plays an important role in disease. Their findings were presented at the American Society of Human Genetics (ASHG) 2014 Annual Meeting in San Diego. Researchers at the University of Washington analyzed the genomes of 2,551 humans, 86 apes, one Neanderthal, and one Denisovan Continue reading